Abstract:
:Since the classic experiments by Tigerstedt and Bergman that established the role of renin in hypertension a century ago, aggressive efforts have been launched to effectively block the renin-angiotensin system (RAS). Blockade of RAS is advocated at multiple levels by direct renin inhibitor, angiotensin-converting enzyme inhibitor and/or angiotensin II type 1 receptor blocker, or aldosterone inhibitor (spironolactone), and has now become part of the standard of care to control hypertension and related metabolic diseases including diabetes. However, recent lessons learned from randomized clinical trials question the wisdom of blocking RAS at multiple levels. In this context, it is highly pertinent that components of RAS are evolutionarily conserved, and novel physiological/adaptive/protective roles for renin and angiotensin-converting enzyme are currently emerging. Angiotensin II, the classical RAS effector peptide responsible for hypertension, hypertrophy, fluid retention and fibrosis, manifests its cardiovascular protective effect when it activates the angiotensin II type 2 receptor. Additionally, angiotensin-converting enzyme 2 and the angiotensin II metabolite Ang-(1-7) that acts through the Mas proto-oncogene constitute the cardiovascular and renal protective branch of RAS. It is conceivable that modulating this vasodilative/anti-inflammatory branch of RAS by activation of the RAS components that constitute this branch may offer a safer long-term treatment strategy to balance RAS activity and achieve homeostasis compared to chronic multilevel RAS inhibition.
journal_name
Cardiorenal Medjournal_title
Cardiorenal medicineauthors
Gul R,Ramdas M,Mandavia CH,Sowers JR,Pulakat Ldoi
10.1159/000343456subject
Has Abstractpub_date
2012-12-01 00:00:00pages
268-280issue
4eissn
1664-3828issn
1664-5502pii
crm-0002-0268journal_volume
2pub_type
杂志文章abstract:BACKGROUND:Human resistin is a proinflammatory cytokine with significant proatherogenic effects which acts through adenylyl cyclase-associated protein 1 (CAP1). Chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients have increased cardiovascular risk and resistin levels. Previous studies indicated res...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
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journal_title:Cardiorenal medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000485196
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Data on the associations between serum osmolality (sOsmo) and acute kidney injury (AKI) as well as short- and long-term mortality in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) are limited. OBJECTIVES:To investigate the association between sOsmo and develo...
journal_title:Cardiorenal medicine
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Cardiorenal medicine
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更新日期:2017-06-01 00:00:00
abstract::BACKGROUND/AIMS: Arsenic (As) is linked to insulin resistance in animal studies, but the effect of low-level As exposure on the prevalence of diabetes in humans is uncertain. An optimal method to report inorganic As in humans has not been established. Measurements of As in spot urine are usually adjusted to creatinine...
journal_title:Cardiorenal medicine
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doi:10.1159/000334225
更新日期:2012-02-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000355136
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Intraoperative hemolysis and inflammation are associated with acute kidney injury (AKI) following cardiac surgery. Plasma-free hemoglobin induces heme oxygenase-1 (HO-1) expression. HO-1 degrades heme but increases in experimental models of AKI. This study tested the hypothesis that plasma HO-1 concentration...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000357871
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND/AIM:To investigate the role of oxidative stress (OS) in the development of chronic kidney disease (CKD) in atrial fibrillation (AF). METHODS:We compared OS burden, determined at study inclusion as plasma concentrations of oxidized low-density lipoprotein (oxLDL), between stable AF patients (n = 256, mean ag...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000351008
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common postoperative complications in intensive care medicine. Baicalin has been shown to have anti-inflammatory and antioxidant roles in various disorders. We aimed to test the protective effects of baicalin on CSA-AKI using a ...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000507727
更新日期:2020-12-17 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000337082
更新日期:2012-05-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000368375
更新日期:2014-12-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000327021
更新日期:2011-01-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000381629
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Bardoxolone methyl has been shown to increase eGFR in several clinical trials, including a phase 3 trial in patients with type 2 diabetes and stage 4 CKD (BEACON), which was terminated early due to an increase in heart failure events in bardoxolone methyl-treated patients. A separate, "thorough QT" study was...
journal_title:Cardiorenal medicine
pub_type: 杂志文章,随机对照试验
doi:10.1159/000500736
更新日期:2019-01-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000479013
更新日期:2017-10-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000433447
更新日期:2015-10-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000371900
更新日期:2015-04-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000446294
更新日期:2016-08-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000329930
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Cardiovascular surgery-associated acute kidney injury (AKI-CS) contributes to mortality and morbidity. However, risk factors accelerating its development are unclear. We identified risk factors for AKI-CS in patients with cardiopulmonary bypass in the hospital surgical intensive care unit to predict and minimiz...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000444094
更新日期:2016-05-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000443620
更新日期:2016-02-01 00:00:00
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journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000365937
更新日期:2014-12-01 00:00:00