Abstract:
:BACKGROUND/AIMS: Arsenic (As) is linked to insulin resistance in animal studies, but the effect of low-level As exposure on the prevalence of diabetes in humans is uncertain. An optimal method to report inorganic As in humans has not been established. Measurements of As in spot urine are usually adjusted to creatinine (Cr). However, urinary Cr is an independent variable in diabetes. Our aims are to optimize reporting of urinary As in the setting of diabetes and insulin resistance. METHODS: Urinary inorganic As was measured in 24-hour or first-void spot urine from diabetic (n = 31) and non-diabetic (n = 12) subjects and normalized to Cr or specific gravity (SG). The relation of normalized urinary inorganic As to glycemia and surrogate measures of insulin resistance was investigated. Blood pressure, waist circumference, and glycated hemoglobin were also assessed. Homeostasis model assessment was used to determine insulin resistance. RESULTS: A strong correlation was found between spot urinary As adjusted to Cr (R(2) = 0.82) or SG (R(2) = 0.61) to 24-hour urinary As (p < 0.001), while non-adjusted urinary As did not correlate well (R(2) = 0.03, p = 0.46). Adjusting for Cr revealed significant differences in total 24-hour urinary As when comparing diabetic to normal subjects. In contrast, no differences were found when As was adjusted to SG using either 24-hour or spot urine. Moreover, adjusted urinary spot or 24-hour As measures did not correlate with measures of glycemia or insulin resistance. Conclusions: Urinary Cr is an independent variable in diabetes, therefore adjusting spot As for SG is preferred.
journal_name
Cardiorenal Medjournal_title
Cardiorenal medicineauthors
Yassine H,Kimzey MJ,Galligan MA,Gandolfi AJ,Stump CS,Lau SSdoi
10.1159/000334225subject
Has Abstractpub_date
2012-02-01 00:00:00pages
26-32issue
1eissn
1664-3828issn
1664-5502pii
crm-0002-0026journal_volume
2pub_type
杂志文章abstract:BACKGROUND:Bardoxolone methyl has been shown to increase eGFR in several clinical trials, including a phase 3 trial in patients with type 2 diabetes and stage 4 CKD (BEACON), which was terminated early due to an increase in heart failure events in bardoxolone methyl-treated patients. A separate, "thorough QT" study was...
journal_title:Cardiorenal medicine
pub_type: 杂志文章,随机对照试验
doi:10.1159/000500736
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Human resistin is a proinflammatory cytokine with significant proatherogenic effects which acts through adenylyl cyclase-associated protein 1 (CAP1). Chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients have increased cardiovascular risk and resistin levels. Previous studies indicated res...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000503416
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Several methods have been developed to assess the hydration status in chronic hemodialysis (HD) patients. The aim of this study was to compare body bioimpedance spectroscopy (BIS) with ultrasound (US) lung comet score (ULCs), B-type natriuretic peptide (BNP) and inferior vena cava diameter (IVCD) by US for t...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000351008
更新日期:2013-07-01 00:00:00
abstract::Insulin (INS) metabolic signaling is important for normal cardiovascular and renal function as well as for exerting the classic actions of INS, such as glucose uptake in skeletal muscle tissue. There is emerging evidence that tyrosine phosphatases as well as protein kinases have important modulating roles in INS metab...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000343889
更新日期:2012-12-01 00:00:00
abstract:AIMS:The purposes of this study were (1) to compare body composition, physical function, and quality of life (QOL) between patients after coronary artery bypass grafting (CABG) with and without chronic kidney disease (CKD) and (2) to analyze the factors associated with physical function and QOL domains in these patient...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000433447
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND/AIM:To investigate the role of oxidative stress (OS) in the development of chronic kidney disease (CKD) in atrial fibrillation (AF). METHODS:We compared OS burden, determined at study inclusion as plasma concentrations of oxidized low-density lipoprotein (oxLDL), between stable AF patients (n = 256, mean ag...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000449173
更新日期:2016-11-01 00:00:00
abstract:Background/Aims:Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully und...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000479013
更新日期:2017-10-01 00:00:00
abstract::BACKGROUND: Vitamin D deficiency and secondary rises in parathyroid hormone (PTH) are highly prevalent in obese African-Americans. Endothelial dysfunction related to oxidative stress is more common in African-Americans compared to whites. Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH t...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000339942
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND/AIMS:Renal dysfunction is associated with a higher risk of cardiovascular disease in patients with acute myocardial infarction (AMI). The aim of this study was to investigate the independent prognostic value of renal dysfunction and its incremental predictability risk after adjusting for well-known clinical ...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000327021
更新日期:2011-01-01 00:00:00
abstract::Periodontal disease is a chronic inflammatory disorder and being so it has been associated with accelerated atherosclerosis and malnutrition. Cardiovascular diseases are the leading cause of mortality in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients [National Institutes of Health, National I...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000350046
更新日期:2013-04-01 00:00:00
abstract::Malnutrition and inflammation are strong predictors of mortality in advanced kidney disease, especially in patients on renal replacement therapy. The complex relationship between kidney disease, uremia, and malnutrition significantly contributes to the increased morbidity and mortality in this patient population poten...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000329930
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Statins have long been prescribed for the primary and secondary prevention of cardiovascular disease (CVD) and kidney disease. Their benefits and efficacy are widely accepted in current clinical practice, but like any other therapeutic agents, they have adverse effects. One of the emerging concerns with stat...
journal_title:Cardiorenal medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000485196
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Many patients admitted to a Department of Internal Medicine have different degrees of heart and kidney dysfunction. Mortality, morbidity and cost of care greatly increase when cardiac and renal diseases coexist. METHODS:A retrospective cohort study was conducted on 1,087 patients admitted from December 2009...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000362566
更新日期:2014-08-01 00:00:00
abstract::Since the classic experiments by Tigerstedt and Bergman that established the role of renin in hypertension a century ago, aggressive efforts have been launched to effectively block the renin-angiotensin system (RAS). Blockade of RAS is advocated at multiple levels by direct renin inhibitor, angiotensin-converting enzy...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000343456
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common postoperative complications in intensive care medicine. Baicalin has been shown to have anti-inflammatory and antioxidant roles in various disorders. We aimed to test the protective effects of baicalin on CSA-AKI using a ...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000492159
更新日期:2019-01-01 00:00:00
abstract::Metformin and asymmetric dimethylarginine (ADMA) are structural analogs. They have opposite effects at multiple points on complex signaling pathways that coordinate energy, molecular synthesis, growth, and metabolism with nutrient intake. Excess saturated fats and glucose may initiate the methylation of arginine resid...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000332382
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Cardiorenal syndrome (CRS) is associated with increased cardiovascular morbidity and mortality; still, its biomarker pattern has been poorly evaluated so far. The aim of this study was to measure the inflammatory activation, neurohormonal status and kidney and myocardial damage in patients with CRS compared ...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000368375
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Its pathophysiology is complex and not completely understood. In this study, we examined the role of apoptosis and the caspase pathways involved. MATERIAL AND METHODS:We e...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000488949
更新日期:2018-01-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is a global pandemic affecting more than 200 countries and 180,000 cases in the United States. While the outbreak began in China, the number of cases outside of China exceeded those in China on March 15, 2020 and are currently rising at an exponential rate. The number of fatalities ...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000508179
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Intraoperative hemolysis and inflammation are associated with acute kidney injury (AKI) following cardiac surgery. Plasma-free hemoglobin induces heme oxygenase-1 (HO-1) expression. HO-1 degrades heme but increases in experimental models of AKI. This study tested the hypothesis that plasma HO-1 concentration...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000357871
更新日期:2014-04-01 00:00:00
abstract:AIM:To determine if children and adolescents who have obesity (Ob) or type 2 diabetes (T2DM) of relatively short duration have impaired cardiovascular function compared with lean subjects using 24-hour ambulatory blood pressure as a surrogate measure of evaluation. METHODS:We enrolled 100 African-Caribbean subjects (4...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000381629
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The pathophysiology of renal disease progression in autosomal-dominant polycystic kidney disease (ADPKD) involves not only cystogenesis but also endothelial dysfunction, leading to the activation of inflammatory and fibrotic pathways. This study evaluated the levels of biomarkers related to osmoregulation, i...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000510834
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Incremental hemodialysis (HD) is a strategy utilized to gradually intensify dialysis among patients with incident end-stage renal disease. However, there are scarce data about which patients' clinic status changes by increasing treatment frequency. METHODS:We retrospectively examined statistically de-identif...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000504383
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In adults, both obesity and type 2 diabetes mellitus (T2DM) are positively correlated with cardiovascular disease mortality and arterial stiffness. Several studies of adults have shown that both obesity and T2DM are independently associated with increased arterial stiffness. However, little is known about th...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000365937
更新日期:2014-12-01 00:00:00
abstract::The key role of chronic inflammation in the pathogenesis of atherosclerosis has become increasingly apparent in recent years based on the results of experimental, epidemiologic and clinical studies. Coronary artery disease and its complications occur with disproportionately high frequency in patients with end-stage re...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000337082
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Post-transplant diabetes mellitus (PTDM) is both common and associated with poor outcomes after kidney transplantation. Our objective was to examine relationships of uremia-associated inflammation and adiponectin with PTDM. METHODS:Nondiabetic kidney transplant patients were enrolled with donor co...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000446294
更新日期:2016-08-01 00:00:00
abstract::Left ventricular assist devices (LVADs) are used increasingly as a bridge to transplantation or as destination therapy in end-stage heart failure patients who do not respond to optimal medical therapy. Many of these patients have end-organ dysfunction, including advanced kidney dysfunction, before and after LVAD impla...
journal_title:Cardiorenal medicine
pub_type: 杂志文章,评审
doi:10.1159/000369589
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The risk of cardiovascular (CV) complications is much greater in patients with chronic kidney disease (CKD). The aim of this study was to assess predictors of mortality, renal failure progression, and the need for dialysis in patients with CKD. METHODS:The study group consisted of 70 patients with stage 3-5...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000496238
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Cardiovascular surgery-associated acute kidney injury (AKI-CS) contributes to mortality and morbidity. However, risk factors accelerating its development are unclear. We identified risk factors for AKI-CS in patients with cardiopulmonary bypass in the hospital surgical intensive care unit to predict and minimiz...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000444094
更新日期:2016-05-01 00:00:00
abstract:AIM:To derive an echocardiography-based prognostic score for a 3-year risk of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). METHODS:173 ESRD patients hospitalized in the second affiliated hospital of Soochow University from January 1, 2010, to July 31, 2016, were enrolled and follo...
journal_title:Cardiorenal medicine
pub_type: 杂志文章
doi:10.1159/000507727
更新日期:2020-12-17 00:00:00