Abstract:
OBJECTIVE:Patients with end-stage renal disease are susceptible to cardiac valve calcification (CVC) due to mineral metabolism disorders and other factors. The purpose of this study was to investigate the risk factors for new-onset CVC in patients on maintenance peritoneal dialysis (PD). METHODS:This study included patients who underwent PD catheter insertion from January 2006 to June 2013 in our Peritoneal Dialysis Center. Clinical data were collected on CVC status during echocardiography evaluations (twice) at an interval of >6 months. The data collected included intact parathyroid hormone, C-reactive protein (CRP), serum phosphorus (P), serum calcium (Ca), albumin (Alb), prealbumin and the use of five types of antihypertensive drugs, statins, active vitamin D3 and Ca tablets. RESULTS:In total, 194 patients - 105 (54.1%) men, average age 60.5 ± 13.0 years - were included. CVC was present in 50 (25.8%) patients during PD catheter placement. After an average PD duration of 20.9 ± 10.4 months, CVC was detected in 97 patients (50.0%). New-onset CVC was found in 62 patients (32.0%). Multivariate logistic regression analysis revealed that only serum P levels (p = 0.01, OR = 2.569), Alb levels (p = 0.04, OR = 0.935), dialysis duration (p = 0.03, OR = 1.039) and CRP levels (p = 0.02, OR = 1.031) were associated with CVC. CONCLUSION:Serum P, Alb and CRP levels as well as dialysis duration are independent risk factors for CVC.
journal_name
Cardiorenal Medjournal_title
Cardiorenal medicineauthors
Tian Y,Feng S,Zhan Z,Lu Y,Wang Y,Jiang S,Song K,Shen Hdoi
10.1159/000443620subject
Has Abstractpub_date
2016-02-01 00:00:00pages
150-8issue
2eissn
1664-3828issn
1664-5502pii
crm-0006-0150journal_volume
6pub_type
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