Abstract：
:Molecular aging of proteins results from the complex association of different reactions that lead to the progressive alteration of their structural and functional properties. These reactions, which include oxidation, glycoxidation, carbonylation and carbamylation, occur during aging and are amplified in various chronic diseases such as diabetes or chronic renal failure. Specific compounds generated throughout this process called post-translational modification derived products (PTMDPs) have been suggested to be promising biomarkers for the management of chronic diseases. During the last decades, the emergence of mass spectrometry and proteomics has largely contributed to the development of sensitive and specific analytical methods devoted to PTMDP quantification in biological fluids. This review aimed at providing evidences for the clinical relevance of PTMDPs as biomarkers in chronic diseases, and at emphasizing on the contribution of mass spectrometric and proteomic methods in this field. Different issues that should be addressed in order to ensure the implementation of these biomarkers in clinical practice have been highlighted. This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine.
journal_name
J Proteomicsjournal_title
Journal of proteomicsauthors
Gillery P,Jaisson Sdoi
10.1016/j.jprot.2013.02.015subject
Has Abstractpub_date
2013-10-30 00:00:00pages
228-38eissn
1874-3919issn
1876-7737pii
S1874-3919(13)00090-0journal_volume
92pub_type
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journal_title：Journal of proteomics
pub_type： 杂志文章
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journal_title：Journal of proteomics
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Journal of proteomics
pub_type： 杂志文章
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更新日期：2020-04-30 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2018.06.002
更新日期：2018-09-15 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2013.08.016
更新日期：2013-10-08 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2019.103491
更新日期：2019-10-30 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2014.01.010
更新日期：2014-02-26 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2013.05.037
更新日期：2013-08-26 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2015.07.021
更新日期：2016-02-16 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2012.06.033
更新日期：2012-09-18 00:00:00
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pub_type： 杂志文章
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更新日期：2009-08-20 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2015.09.016
更新日期：2016-03-01 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2013-12-06 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-16 00:00:00
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journal_title：Journal of proteomics
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journal_title：Journal of proteomics
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of proteomics
pub_type： 杂志文章
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journal_title：Journal of proteomics
pub_type： 杂志文章,评审
doi：10.1016/j.jprot.2011.07.024
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