Severe open tibial fractures: a study protocol.

Abstract:

:A prospective randomized study of severe open tibial fractures (Type II and III) was performed. Individual fractures were randomized to treatment groups according to initial antibiotic therapy: One consisted of a first-generation cephalosporin, and the other consisted of a third-generation cephalosporin. Initial antibiotic therapy was given in all patients for 48 h and then specific antibiotic treatment was used as indicated by culture. The purpose of this study was to determine whether or not additional gram-negative coverage had an effect on the overall infection rate or the type of infection in severe open tibial fractures. Additional factors, such as the timing of bone grafts and soft tissue coverage, were evaluated in this study as well. Although there was no statistical difference in the rate of infection with the use of a first- versus a third-generation cephalosporin, there was a trend toward a decreased infection rate as well as toward less morbid infections with the use of a third-generation cephalosporin. The study also confirms that early bone graft should not be performed prior to 6 weeks post injury or after successful soft tissue coverage has been achieved. On the other hand, soft tissue coverage procedures should be performed at the earliest possible date to decrease the overall infection rate.

journal_name

J Orthop Trauma

authors

Johnson KD,Bone LB,Scheinberg R

doi

10.1097/00005131-198802030-00001

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

175-80

issue

3

eissn

0890-5339

issn

1531-2291

journal_volume

2

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章,随机对照试验

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    更新日期:2017-05-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2011-12-01 00:00:00

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