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Small interfering RNA targeting nuclear factor kappa B to prevent vein graft stenosis in rat models.

Abstract：

BACKGROUND:Intimal hyperplasia plays an important role in vein graft stenosis. Inflammatory injury, especially nuclear factor kappaB (NF-κB) gene activation, is highly involved in stenosis progression. We examined whether neointimal hyperplasia and vein graft stenosis could be inhibited by silencing the NF-κB gene with small interference RNA (siRNA). METHODS:Sixty adult male Sprague-Dawley rats were randomly divided into a normal vein group, a vein graft group, a scrambled siRNA group, and an NF-κB siRNA group. We performed reverse interpositional grafting of the autologous external jugular vein to the abdominal aorta. Vein grafts were treated with liposome and gel complexes containing NF-κB siRNA or scrambled siRNA. The levels of monocyte chemoattractant protein -1, tumor necrosis factor-α, and NF-κB p65 in vessel tissues were evaluated after surgery for content of proliferating cell nuclear antigen (PCNA) and vascular wall thickness. RESULTS:NF-κB siRNA treated vein graft showed less neointimal formation and fewer positive PCNA cells (P < .05). In addition there were lower levels of, NF-κB p65 protein and of inflammatory mediators (P < .05) compared with the vein graft group. CONCLUSION:Our study suggested that siRNA transfection suppressed NF-κB expression, reduced inflammatory factors, lessened neointimal proliferation, and suppressed PCNA.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Meng XB,Bi XL,Zhao HL,Feng JB,Zhang JP,Song GM,Sun WY,Bi YW

doi

10.1016/j.transproceed.2013.03.045

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2553-8

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00527-7

journal_volume

45

pub_type

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