当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Prolongation of islet allograft survival by coexpression of CTLA4Ig and CD40LIg in mice.

Prolongation of islet allograft survival by coexpression of CTLA4Ig and CD40LIg in mice.

Abstract：

BACKGROUND:B7/CD28 and CD40/CD40L have been well established as important costimulatory pathways. Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) delivers negative signals to antigen-presenting cells to down-regulate proinflammatory responses and competitively inhibits the binding of B7 and CD28. Signals from the CD40/CD40L costimulatory pathway also play an important role in acute rejection of organ grafts. METHODS:Recombinant adenoviruses Ad-sCD40LIg-IRES2-CTLA4Ig, Ad-CTLA4Ig, and Ad-sCD40LIg were constructed to express sCD40LIg and CTLA4Ig simultaneously or separately as described previously. Streptozocin-induced diabetic BALB/c mice were injected with recombinant adenovirus, receiving approximately 500 donor islets isolated from C57BL/6 mice under the left kidney capsule. Five groups were assigned according to the treatment: nontreated group, Ad-Shuttle-CMV-treated group, Ad-CTLA4Ig-treated group, Ad-sCD40LIg-treated group, and Ad-sCD40LIg-IRES2-CTLA4Ig-treated group. The islet graft mean survival time (MST) was evaluated in the present study. RESULTS:Compared to the islet graft MST of the nontreated group (7.3+/-0.82 days) or Ad-Shuttle-CMV-treated group (7.2+/-1.47 days), the Ad-CTLA4Ig-treated and Ad-CD40LIg-treated islet graft survivals in recipients were 56.3+/-13.71 days (P<.01) and 47.3+/-15.64 days (P<.05), respectively. The islet graft MST was dramatically prolonged to 116.3+/-20.32 days in the Ad-sCD40LIg-IRES2-CTLA4Ig-treated group (P<.01). CONCLUSION:Simultaneous blockade of the CD40/CD40L and B7/CD28 costimulatory pathways via coexpression of sCD40LIg and CTLA4Ig mediated by replication-defective adenovirus may be an acceptable method to induce immune tolerance.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Li ZL,Xue WJ,Tian PX,Ding XM,Tian XH,Feng XS,Hou J

doi

10.1016/j.transproceed.2007.09.025

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

3436-7

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)01241-9

journal_volume

39

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Effects of an exercise training program in physical condition after liver transplantation in familial amyloidotic polyneuropathy: a case report.

    abstract：INTRODUCTION:Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease that leads to sensory and motor polyneuropathies as well as functional limitations. So far, liver transplantation is the only treatment for FAP because the mutated protein causing the disease is mainly produced in the liver. With the ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.12.025

    authors： Tomás MT,Santa-Clara H,Monteiro E,Barroso E,Sardinha LB

    更新日期：2011-01-01 00:00:00

  • Influence of Double-J Catheters on Urinary Infections After Kidney Transplantation.

    abstract：BACKGROUND:One of the most important problem in kidney transplantation is risk of the urinary anastomosis stricture. In uncertain cases the use of a double-J (or JJ) catheter is a standard solution. In case of urinary leak or fistula after the reanastomosis operation, transuretheral JJ implantation is used. A number of...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.03.003

    authors： Jonas M,Jóźwik A,Kawecki D,Durlik M,Pączek L,Młynarczyk G,Chmura A

    更新日期：2016-06-01 00:00:00

  • Heat inactivation can differentiate between IgG and IgM antibodies in the pretransplant cross match.

    abstract：:The presence of IgG antibodies in the pretransplant cross-match (XM) test results in hyperacute rejection, but IgM antibodies are inconsequential. The XM should be able to differentiate between IgG and IgM antibodies. This study evaluated 3 methods. This study was based on 500 patients for whom XM were performed betwe...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.07.045

    authors： Al-Muzairai IA,Mansour M,Almajed L,Alkanderi N,Alshatti N,Samhan M

    更新日期：2008-09-01 00:00:00

  • Donor-recipient age difference and graft survival in living donor kidney transplantation.

    abstract：BACKGROUND:In paired living kidney exchange donation from an old donor to a young recipient, it may be argued that elderly donors provide an inferior quality kidney. However, the impact of donors older than recipients on transplant outcomes remains unclear. METHODS:We retrospectively reviewed the charts of primary liv...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.12.013

    authors： Lee YJ,Chang JH,Choi HN,Jung JY,Kim YS,Chung WK,Park YH,Lee HH

    更新日期：2012-01-01 00:00:00

  • Outcomes of simultaneous kidney-pancreas transplantation with positive cross-match.

    abstract：:We studied 72 consecutive simultaneous pancreas kidney transplant (SPKT) recipients. There were 14 patients with positive pretransplant cross-matches (positive CDC- B cell and/or positive flow T or B cross-match). The control group included all 58 SPKT recipients with a negative crossmatch. The study group received in...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.08.154

    authors： Heilman RL,Chakkera H,Mazur M,Petrides S,Moss A,Mekeel K,Mulligan D,Reddy KS

    更新日期：2009-01-01 00:00:00

  • A 6-month, open-label, multicenter clinical study in Korean de novo renal transplant patients evaluating the efficacy, safety, and tolerance of myfortic concomitantly used with tacrolimus.

    abstract：:Enteric-coated mycophenolate sodium (myfortic, Novartis Pharma AG, Basel, Switzerland) is designed to improve the gastrointestinal tolerability of micophenolic acid. This study was designed to evaluate the efficacy and safety of myfortic in Korean de novo renal transplantation. A total of 65 patients from four transpl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2011.12.015

    authors： Ju MK,Park SH,Kim SJ,Moon IS,Kim YS

    更新日期：2012-01-01 00:00:00

  • Correlation of the Renal Cortex Volume With the Glomerular Filtration Rate in Live Donors for Renal Transplantation.

    abstract：INTRODUCTION:As a pretransplantation evaluation, renal function is determined by the glomerular filtration rate (GFR) with the use of renal scintigraphy (RS) and the estimated glomerular filtration rate (eGFR). To date, there are few studies that correlate renal cortex volume with eGFR determined with renal gammagram (...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.12.045

    authors： Garcia-Covarrubias L,Valdéz DR,Bermudez LA,Córdoba R,Avelar FJ,Villanueva RM,Ortuño D,Hernández JC,García A,Castro I

    更新日期：2018-03-01 00:00:00

  • Immunosuppressive agents and metabolic factors of cardiovascular risk in renal transplant recipients.

    abstract：:Cardiovascular disease (CVD) accounts for 35% to 50% of deaths among renal transplant recipients. Beside the atherogenic risk factors related to hemodialysis, renal function, and use of immunosuppressive agents, other relevant risk factors for CVD include acute rejection episodes, microalbuminuria (muAlb), diabetes, a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.02.045

    authors： Sessa A,Esposito A,Giliberti A,Iavicoli G,Costa C,Bergallo M,Lettieri E,Rossano R,Capuano M

    更新日期：2009-05-01 00:00:00

  • Auxiliary partial orthotopic liver transplantation in the treatment of acute liver failure: a case report.

    abstract：:A successful experience with auxiliary partial orthotopic liver transplantation (APOLT) for acute liver failure is reported in a 29-year-old woman who experienced jaundice, generalized erythema for 7 days, and decreased mentation for 3 days. Two months prior, she suffered pulmonary tuberculosis, being currently treate...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.08.072

    authors： Lee DS,Woo JG,Lee HH,Lee KW,Joh JW,Kim SJ,Choi SH,Heo JS,Hyon WS,Kim GS,Lee SK

    更新日期：2004-10-01 00:00:00

  • Donors older than 70 years in liver transplantation.

    abstract：INTRODUCTION:Expansion of donor criteria has become necessary with the increasing number of liver transplantation candidates, as aged donors who have been considered to yield marginal organs. METHODS:Our database of 477 liver transplants (OLT) included 55 cases performed from donors at least 70 years old vs 422 with y...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.10.040

    authors： Gastaca M,Valdivieso A,Pijoan J,Errazti G,Hernandez M,Gonzalez J,Fernandez J,Matarranz A,Montejo M,Ventoso A,Martinez G,Fernandez M,de Urbina JO

    更新日期：2005-11-01 00:00:00

  • Monitoring of CD3(+) T-cell count in patients receiving antithymocyte globulin induction after cadaveric renal transplantation.

    abstract：AIM:Although antithymocyte globulin (ATG) has been used for years, its ideal dose and administration period is obscure. Herein, we sought to use the CD3(+) cell count to detect the optimal ATG dosage. MATERIAL AND METHODS:Twenty-one patients who underwent cadaveric donor renal transplantation from January 2009 to Janu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.02.092

    authors： Ata P,Kara M,Özdemir E,Canbakan M,Gökçe AM,Bayraktar FA,Şahin G,Özel L,Titiz MI

    更新日期：2013-04-01 00:00:00

  • Immunoprophylaxis with Simulect (basiliximab) in kidney transplantation: results from routine clinical practice at 18 kidney transplant units.

    abstract：OBJECTIVE:The objective of this study is to assess a Simulect (basiliximab) regimen in routine clinical practice in the Spanish kidney transplantation units to evaluate efficacy and safety. METHODS:In this prospective, observational study, data on demographics, parameters of efficacy, and safety in patients who under ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0041-1345(03)00575-x

    authors： Rengel M,Fernández Rodriguez A,Gómez Huertas E,Plaza JJ,Ruiz San Millán JC,Oppenheimer F,Bustamante J,Checa D,Sanchez Plumed JA,García Pérez J,Sanz Guajardo A,Llorente S,Martin Govantes JA,Gentil MA,Gomez Ullate P,Sanchez G

    更新日期：2003-08-01 00:00:00

  • Trend Analysis of Organ and Tissue Donation for Transplantation.

    abstract：BACKGROUND:The goal of this study was to identify the tendency toward donations of tissue and organs from donors with brain death between 2001 and 2016 as registered by an organ procurement organization in São Paulo City. METHODS:This quantitative, retrospective, exploratory study encompassed all Tissue and Organ Dona...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.11.075

    authors： Dos Santos MJ,Leal de Moraes E,Santini Martins M,Carlos de Almeida E,Borges de Barros E Silva L,Urias V,Silvano Corrêa Pacheco Furtado MC,Brito Nunes Á,El Hage S

    更新日期：2018-03-01 00:00:00

  • Pneumococcal 13-Valent Conjugate Vaccine (Prevnar 13)-Associated Immune Thrombocytopenic Purpura in a Renal Transplant Recipient: A Case Report.

    abstract：BACKGROUND:Pneumococcal 13-valent conjugate vaccine (PCV13) is used for immunization to prevent invasive disease caused by Streptococcus pneumoniae. Rare cases of idiopathic thrombocytopenic purpura (ITP) after vaccination with PCV13 have been reported. METHODS:A case of ITP associated with PCV13 administration in a r...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.12.004

    authors： Gupta S,Brennan DC

    更新日期：2016-01-01 00:00:00

  • N-Acetylcysteine Use in Hepatic Ischemia/Reperfusion in Rats Minimizing Bowel Injury.

    abstract：BACKGROUND:The ischemia/reperfusion (I/R) phenomenon can cause the dysfunction of some transplanted organs and other distant organs. Liver surgery success, including transplantations, may depend on the adverse effects of intestinal mucosa injury arising from temporary porta triad occlusion. The study objective was to e...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.06.003

    authors： Lauz Medeiros SH,de Oliveira Menezes A,Zogbi L,Frasson de Souza Montero E

    更新日期：2016-09-01 00:00:00

  • Value of pretransplantation cytokine profiles for predicting acute rejection in renal transplant recipients.

    abstract：:Episodes of acute rejection may represent an important risk factor for the development of chronic allograft nephropathy. Various studies have shown that pretransplant cytokine profiles in recipient blood are associated with transplant outcome. Serum samples were collected 24 hours before transplantation from 57 patien...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.08.031

    authors： Lessan-Pezeshki M,Amirzargar A,Fathi A,Khatami MR,Einollahi B,Pourfarziani V,Azmandian J,Khosravi F,Ansaripour B,Nikbin B

    更新日期：2005-09-01 00:00:00

  • Early experience with enteric-coated mycophenolate sodium in de novo kidney transplant recipients.

    abstract：INTRODUCTION:We sought to evaluate the efficacy of enteric-coated mycophenolate sodium (EC-MPS) and the gastrointestinal (GI) adverse events in de novo kidney transplant recipients. METHODS:This noncontrolled, retrospective review includes 22 de novo kidney transplant recipients. All patients received a standard cours...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.03.105

    authors： Chang HR,Lin CC,Lian JD

    更新日期：2005-06-01 00:00:00

  • Neutrophilic reversible airways dysfunction after liver transplantation: a case report.

    abstract：:In the present case report we have described a 46-year-old female patient who underwent a liver transplantation in 1998 for polycystic disease and developed a syndrome of increasing dyspnea, with sputum production and a progressive decline in pulmonary function [forced expiratory volume in one second (FEV(1)) (decreas...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.02.021

    authors： Verleden GM,Vos R,De Vleeschauwer S,Verleden S,Dupont L,Nevens F,Verbeken E,Vanaudenaerde BM

    更新日期：2011-06-01 00:00:00

  • Endothelial nitric oxide synthase protects transplanted mouse livers against storage/reperfusion injury: Role of vasodilatory and innate immunity pathways.

    abstract：:Endothelial nitric oxide synthase (eNOS) plays a role in microcirculatory and immunomodulatory responses after warm ischemia/reperfusion. We hypothesized that eNOS is essential to maintain microcirculation, attenuate macrophage infiltration and decrease graft injury after liver transplantation. Liver transplantation w...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.171

    authors： Theruvath TP,Zhong Z,Currin RT,Ramshesh VK,Lemasters JJ

    更新日期：2006-12-01 00:00:00

  • Respiratory distress syndrome caused by influenza H1N1 in a patient with a simultaneous pancreas-kidney transplantation.

    abstract：:Adult respiratory distress syndrome is a severe respiratory failure due to noncardiogenic pulmonary edema with high mortality rates (50-70%). The most common etiology of respiratory distress is sepsis, but it may also be caused by several of the immunosuppressants prescribed in transplantation. In the last year, influ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.06.015

    authors： Fraile P,Muñoz-Bellvis L,Cacharro LM,García-Cosmes P,Tabernero JM

    更新日期：2013-11-01 00:00:00

  • Correlation of the Volume Control Parameters With Health Related Quality of Life in Renal Transplant Patients.

    abstract：INTRODUCTION:Transplantation is the most effective treatment strategy for end-stage renal failure. We aimed to investigate the correlation of volume control parameters with health-related quality of life (HRQoL) in renal transplantation patients during the pre- and post-transplantation periods. MATERIAL AND METHODS:Se...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.04.012

    authors： Colak H,Sert I,Ekmekcı C,Tugmen C,Kurtulmus Y,Kursat S,Töz H

    更新日期：2015-06-01 00:00:00

  • Changes in Tumor Markers and Their Implications in Selecting Liver Transplantation for Patients With Hepatocellular Carcinoma.

    abstract：BACKGROUND AND AIM:It has been suggested that tumor markers can provide additional information over tumor size and number-based liver transplantation (LT) criteria. We aimed to assess if changes in tumor markers are associated with the risk of tumor recurrence after LT for hepatocellular carcinoma (HCC) who received lo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.01.037

    authors： Song BG,Sinn DH,Kang W,Gwak GY,Paik YH,Choi MS,Lee JH,Koh KC,Paik SW,Kim JM,Joh JW,Choi GS

    更新日期：2020-04-01 00:00:00

  • Survey of medical students of Shahed University in Iran about attitude and willingness toward organ transplantation.

    abstract：BACKGROUND:Transplantation is a successful procedure that prolongs the lives of people suffering from debilitating diseases. The purpose of this study was to assess medical students' attitude toward organ donation. METHODS:The study population consisted of 262 medical students with a mean age of 22.1 +/- 2.5 years who...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.01.080

    authors： Sanavi S,Afshar R,Lotfizadeh AR,Davati A

    更新日期：2009-06-01 00:00:00

  • The role of dendritic cells in the gastrointestinal field effect.

    abstract：INTRODUCTION:Intestinal manipulation leads to local bowel wall inflammation that subsequently spreads over the entire gastrointestinal tract. Previously, this gastrointestinal field effect had been demonstrated by us in a rodent model. We herein postulated an immunologic mechanism mediated by activated leukocytes. The ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.087

    authors： Koscielny A,Boerner T,Wehner S,Kurts C,Kalff JC

    更新日期：2006-07-01 00:00:00

  • Decreased circulating CD4+CD25highFoxp3+ T cells during acute rejection in liver transplant patients.

    abstract：BACKGROUND:CD4(+)CD25(high)FoxP3(+) regulatory T (Treg) cells have been implicated to maintain immunologic tolerance. They have been investigated in acute renal allografts rejection episodes (ARE). This study was performed to examine the frequency of peripheral blood (PB) CD4(+)CD25(high)FoxP3(+) Treg cells among liver...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.03.084

    authors： He Q,Fan H,Li JQ,Qi HZ

    更新日期：2011-06-01 00:00:00

  • Cell surface properties of spontaneously metastasizing rat mammary adenocarcinoma cell clones.

    abstract：:Rat 13762NF mammary adenocarcinoma mimics human breast cancer in its pathology and pathogenesis. We selected and cloned spontaneously metastasizing variant tumor cell lines that spread from mammary fat pad subcutaneous sites to regional lymph nodes and lung. The biologic properties of these tumor clones changed during...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Steck PA,Nicolson GL

    更新日期：1984-04-01 00:00:00

  • Progress in Desensitization of the Highly HLA Sensitized Patient.

    abstract：:The presence of HLA antibodies remains a significant and often impenetrable barrier to kidney transplantation, leading to increased morbidity and mortality for patients remaining on long-term dialysis. In recent years, a number of new approaches have been developed to overcome these barriers. Intravenous immunoglobuli...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.11.027

    authors： Jordan SC,Choi J,Kahwaji J,Vo A

    更新日期：2016-04-01 00:00:00

  • Best results in living donor transplantation using an aggressive policy in microsurgical bench reconstruction of nonoptimal arterial supply.

    abstract：:The increasing of number of patients awaiting kidney transplantation have forced surgeons to use nonoptimal organs, such as kidneys with multiple/diseased arteries as well as those coming from living donors (LDs). Two hundred and sixty six LD transplants performed in cyclosporine era included 44 coming from a LD over ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.03.062

    authors： Berardinelli L

    更新日期：2006-05-01 00:00:00

  • Left Hepatic Lobectomy in the Living Donor-Comparison Between Open vs Laparoscopic Surgery.

    abstract：:Laparoscopic hepatic surgery dramatically changed surgical practice in the last decades, improving outcomes in correctly selected patients. The reduction of postoperative pain, lower rate of complication, early return to work activities, and better esthetic result have been well described in several studies. The succe...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.03.003

    authors： Vieira V,Pacheco L,Demetrio L,Balbi E,Bellinha T,Toledo R,Auler L,Pestana D,Schul M

    更新日期：2019-06-01 00:00:00

  • Clinical pharmacokinetics of tacrolimus after the first oral administration in combination with mycophenolate mofetil and prednisone in Chinese renal transplant recipients.

    abstract：INTRODUCTION:Data on tacrolimus pharmacokinetics in combination with mycophenolate mofetil and prednisone are scarce in Chinese renal transplantation recipients. The purpose of this study was to detect interpatient pharmacokinetic variability of tacrolimus and to assess the predictability of individual tacrolimus conce...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.11.055

    authors： Chen YH,Zheng KL,Chen LZ,Dai YP,Fei JG,Qiu J,Li J

    更新日期：2005-12-01 00:00:00