当前位置： SCI文献检索 > ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA期刊下所有文献 > Guided antibiotic therapy for Mycoplasma genitalium infections: Analysis of mutations associated with resistance to macrolides and fluoroquinolones.

Guided antibiotic therapy for Mycoplasma genitalium infections: Analysis of mutations associated with resistance to macrolides and fluoroquinolones.

Abstract：

INTRODUCTION:The objective of this study was to analyse the susceptibility of Mycoplasma genitalium to macrolides and fluoroquinolones using molecular techniques. METHODS:Susceptibility to macrolides was tested (Gipuzkoa, 2014-2017) by a rapid probe-based real-time polymerase chain reaction assay (23S rRNA gene) and to fluoroquinolones by sequencing the parC and gyrA genes. RESULTS:Mutations associated with macrolide resistance were detected in 43/263 (16.3%) cases and potential fluoroquinolone resistance in 21/267 (7.9%). Macrolide resistance was more frequent in patients previously treated with azithromycin (76.5% vs 7.4%, P<.001) as well as in those treated with a single 1g dose (31.3%) vs the extended regimen (7%, P<.001). There were 5/245 (2%) cases with mutations probably associated with resistance to both antibiotics. CONCLUSIONS:The technique used for testing Mycoplasma genitalium susceptibility to azithromycin allowed the rapid implementation of resistance-guided antibiotic therapy. Moxifloxacin could be a good option in cases of macrolide resistance.

journal_name

Enferm Infecc Microbiol Clin

journal_title

Enfermedades infecciosas y microbiologia clinica

authors

Piñeiro L,Idigoras P,de la Caba I,López-Olaizola M,Cilla G

doi

10.1016/j.eimc.2018.10.003

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

394-397

issue

6

eissn

0213-005X

issn

1578-1852

pii

S0213-005X(18)30274-X

journal_volume

37

pub_type

杂志文章

相关文献

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA文献大全
  • [Bronchiolitis caused by influenza type A virus. An emerging infectious disease].

    abstract：OBJECTIVES:To prospectively study the emergence and diagnostic problems of bronchiolitis caused by influenza A virus among children durign the 1999-2000 influenza epidemic. MATERIALS AND METHODS:Negative respiratory syncitial virus (RSV) specimens (ELISA dot-blot) were seeded in the MDCK cell line for the isolation of...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/s0213-005x(01)72703-6

    authors： Reina J,Ballesteros F,Mesquida X,Galmes M,Ferres F,Ruiz De Gopegui E

    更新日期：2001-12-01 00:00:00

  • [Campylobacter bacteremia and HIV infection].

    abstract：:Bacteremia due to Campylobacter is a rare infection. Patients with HIV infection are an important risk group for this condition. We describe here two patients with Campylobacter bacteremia and advanced HIV infection. One case was due to C. jejuni infection in a drug addict, being also isolated C. jejuni in stool sampl...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Vargas J,Corzo JE,Pérez MJ,Lozano F,Martín E

    更新日期：1992-03-01 00:00:00

  • [Microbiological parameters of clinical interest in pulmonary infection in cystic fibrosis].

    abstract：BACKGROUND:A 5-year study in patients with cystic fibrosis was carried out in order to gain a better understanding of the microbiological factors influencing clinical status and evolution. METHODS:Fifty-two patients were evaluated (mean age 16.6 years, range 0-36) during a 5 years-period (July 1988- July 1992). The cl...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Ballestero S,Escobar H,Suárez L,Baquero F

    更新日期：1996-04-01 00:00:00

  • [Neonatal infection by Streptococcus agalactiae. Multicenter study in the area of Barcelona, Spain].

    abstract：BACKGROUND:Streptococcus agalactiae or streptococcus group B (SGB) is the main etiologic agent of early neonatal sepsis. A multicenter study was performed with the aim of determining the incidence and characteristics of this disease in our medium and contribute the design of an adequate prevention protocol. METHODS:Te...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Juncosa T,Bosch J,Dopico E,Guardia C,Lite J,Sierra M,Andreu A,Barranco M,Matas L,Sánchez F,Sanfeliu I,Viñas L

    更新日期：1998-08-01 00:00:00

  • [New anaerobic bacterial species in human infections].

    abstract：:This review offers succinct, precise, and complete information based on the available data concerning new anaerobic bacterial species involved in infectious diseases in humans. All hitherto undescribed species, those not previously implicated in clinical conditions, those with confirmed implication in human disease th...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：10.1016/j.eimc.2008.09.015

    authors： García-Sánchez JE,José Fresnadillo M,García-Sánchez E

    更新日期：2010-03-01 00:00:00

  • [Use of rifampicin plus pyrazinamide for antituberculosis prophylaxis does not increase the risk of severe hepatotoxicity in HIV patients: meta-analysis of randomized controlled clinical trials].

    abstract：OBJECTIVE:To compare the incidence of severe hepatitis in HIV-infected patients receiving rifampicin plus pyrazinamide (RZ) for antituberculosis prophylaxis with that of patients receiving a conventional isoniazid-based regime for 6 to 12 months (6-12H). METHODS:Meta-analysis of randomized controlled trials, in which ...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.eimc.2009.04.003

    authors： Camacho A,Pérez-Camacho I,Rivero A,Natera C,García-Lázaro M,Castón JJ,Gallo M,Kindelán JM,Torre-Cisneros J

    更新日期：2010-04-01 00:00:00

  • [Serological parameters for the diagnosis and follow-up of toxoplasmosis. Experimental models].

    abstract：BACKGROUND:Toxoplasmosis is a disease of increasing incidence. Its laboratory diagnosis is difficult, specially in acute toxoplasmosis. The data obtained in experimental models attempting to distinguish between acute and chronic toxoplasmosis by the simultaneous study of four serological tests: IgM and IgG antibodies, ...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Acebes MV,Díez B,Nicolás R,Martín MT,Suñén E,Cisterna R

    更新日期：1994-03-01 00:00:00

  • Surveillance of surgical site infections in elective colorectal surgery. Results of the VINCat Program (2007-2010).

    abstract：:The VINCat Program is a standardized surveillance program of healthcare infections in Catalonia, Spain. This program includes monitoring of surgical site infections (SSI) of elective colorectal surgery. The aim of this study was to define SSI rates in colorectal surgery among VINCat hospitals over a period of 4 years....

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/S0213-005X(12)70092-7

    authors： Pujol M,Limón E,López-Contreras J,Sallés M,Bella F,Gudiol F,VINCat Program.

    更新日期：2012-06-01 00:00:00

  • [Longitudinal study on adherence, treatment satisfaction, and effectiveness of once-daily versus twice-daily antiretroviral therapy in a Spanish cohort of HIV-infected patients (CUVA study)].

    abstract：INTRODUCTION:Adherence is essential for successful antiretroviral therapy (ART), but complex dosing schedules compromise the adherence to and efficacy of this treatment. Once-daily (QD) ART simplifies treatment by lowering the dosing frequency and pill burden. The aim of this study, performed when QD regimens were stil...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,多中心研究

    doi：10.1157/13116748

    authors： Viciana P,Rubio R,Ribera E,Knobel H,Iribarren JA,Arribas JR,Pérez-Molina JA,Investigadores del Estudio CUVA.

    更新日期：2008-03-01 00:00:00

  • [Hepatitis B at an open institution for the mentally retarded. Immunogenic effect of a recombinant anti-hepatitis-B vaccine].

    abstract：:The diffusion of hepatitis B virus was investigated in an open institution for mentally retarded patients, where 24 patients with Down's syndrome (DS) and 94 with other types of mental retardation (OMR) were being cared for. The immunogenic response to a recombinant vaccine intramuscularly injected to the deltoid musc...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：

    authors： García O,Bruguera M,Mayor A,Sánchez-Tapias JM,Vall O,Rodés J

    更新日期：1990-03-01 00:00:00

  • Enterovirus reverse transcriptase polymerase chain reaction assay in cerebrospinal fluid: an essential tool in meningitis management in childhood.

    abstract：BACKGROUND:Enteroviruses (EV) are the main aetiological agents of aseptic meningitis in children and a common cause of febrile illnesses in young infants in summer. A rapid diagnosis is essential to rule out other conditions. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay performed in cerebros...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/j.eimc.2012.07.007

    authors： Menasalvas-Ruiz AI,Salvador-García C,Moreno-Docón A,Alfayate-Miguélez S,Pérez Cánovas C,Sánchez-Solís M

    更新日期：2013-02-01 00:00:00

  • Influenza infection in the intensive care unit: Four years after the 2009 pandemic.

    abstract：UNLABELLED:The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied. OBJECTIVE:To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/j.eimc.2015.04.004

    authors： Pérez-Carrasco M,Lagunes L,Antón A,Gattarello S,Laborda C,Pumarola T,Rello J,CRIPS investigators.

    更新日期：2016-03-01 00:00:00

  • [Meningococcal infection caused by Neisseria meningitidis serogroup C].

    abstract：BACKGROUND:In recent years an increase has been observed in the prevalence of meningococcal infection by Neisseria meningitidis serogroup C and in the appearance of strains with moderate resistance to penicillin. PATIENTS AND METHODS:A microbiologic study of the cases of meningococcal infection of serogroup C treated ...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Ursua MI,Rodríguez-Mayo M,Fernández-Quintairos J,Domínguez D,Luaces J,Agulla A

    更新日期：1997-08-01 00:00:00

  • [Clinical significance of Streptococcus agalactiae isolation from urine samples of outpatients from health care centers].

    abstract：INTRODUCTION:Streptococcus agalactiae is a well-recognized pathogen in the obstetric population and is a cause of invasive infection in adults with underlying diseases. Nevertheless, the role of S. agalactiae in urinary tract infections in the adult non-pregnant population treated in outpatient health care centers has ...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/s0213-005x(04)73040-2

    authors： Hernáiz C,Antón N,Alós JI,Orden B,Orellana MA,Colomina J,Redondo J,Gómez-Garcés JL

    更新日期：2004-02-01 00:00:00

  • [Practice variation and appropriateness study of antimicrobial therapy for acute pharyngotonsillitis in adults].

    abstract：OBJECTIVE:Infectious pharyngotonsillitis is usually managed with antibiotics by general practitioners and pediatricians both in primary care and the emergency services. In the present work we try to assess the antibiotic variability and appropriateness in the management of acute pharyngotonsillitis among several emerge...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Lázaro A,Ochoa C,Inglada L,Eiros JM,Martínez A,Vallano A,Armadans L,Bautista Vidal J,Artero A,Ruiz A,Cerdá T,Guerra L

    更新日期：1999-06-01 00:00:00

  • [Diarrhea associated with Clostridium difficile. One-year retrospective study at a tertiary hospital].

    abstract：BACKGROUND:Diarrhea associated with Clostridium difficile is a health care problem of growing importance in the last few years specially in the hospital environment. The epidemiologic data and factors associated with this disease have not, to date, been sufficiently studied in Spain. METHODS:The cases of diarrhea asso...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Barreiro PM,Pintor E,Rosario Burón M,Díaz B,Valverde J,de la Torre F

    更新日期：1998-10-01 00:00:00

  • Human papillomavirus (HPV) genotype distribution in women with abnormal cervical cytology in the Basque Country, Spain.

    abstract：INTRODUCTION:The aim of this study was to analyze the distribution of human papillomavirus (HPV) genotypes in cytologically abnormal cervical samples from 106 women living in a region of the north of Spain. METHODS:Cytological classification was reported according to the 2001 Bethesda System and HPV genotyping was per...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/j.eimc.2011.10.021

    authors： Delgado D,Marín JM,de Diego J,Guerra S,González B,Barrios JL,Canut A

    更新日期：2012-05-01 00:00:00

  • [Cotrimoxazole plus rifampicin in the treatment of staphylococcal osteoarticular infection].

    abstract：OBJECTIVE:To evaluate the efficacy and safety of cotrimoxazol plus rifampicin in staphylococcal osteoarticular infection. METHOD:Open, non-comparative study of adult hospitalized patients with documented staphylococcal bone infection. RESULTS:From Feb 1989 to Dec 1993 28 episodes of staphylococcal bone infection were...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Sánchez C,Matamala A,Salavert M,Cuchí E,Pons M,Anglés F,Garau J

    更新日期：1997-01-01 00:00:00

  • [Adverse effects of cotrimoxazole in Spanish patients with AIDS and pneumonia caused by Pneumocystis carinii].

    abstract：:We retrospectively analyze the untoward effects due to cotrimoxazole (CMX) when this drug was used as initial therapy in 37 Spanish AIDS patients with Pneumocystis carinii pneumonia (PCP). A total of 46% of patients developed an adverse reaction, that was considered severe in 24.3% of cases, and prompted to stop CMX t...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Pérez-Cortés S,Pérez-Pérez M,Vergara de Campos A,Torres M,Lucero MI,Cifuentes N

    更新日期：1991-08-01 00:00:00

  • [Application of PCR for the detection of mutations in the genes coding for beta-lactamases].

    abstract：BACKGROUND:The purpose of this study was to develop a satisfactory technique to detect punctual mutations in blaTEM genes. METHODS:The strains [E. coli HB 101 pBR322 (TEM-1), E. coli J62 RP4 (TEM-2)] were submitted to PCR with primers PL1 and PL2 which amplify the genetic region susceptible of punctual mutations. Then...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Gallego L,Basaras M,Alonso R,Sarria L,Cisterna R

    更新日期：1993-02-01 00:00:00

  • [Infection by Coxiella burnetii (Q fever)].

    abstract：:In spite of being described over 60 years, Q fever is still a little known disease. The exact prevalence is also unknown, but probably the number of cases of Q fever is underestimated. There is much variation in the clinical presentation, including severe forms with a poor prognosis. Acute cases often present as an as...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：10.1016/S0213-005X(10)70005-7

    authors： Fariñas MT,Collado CM

    更新日期：2010-01-01 00:00:00

  • Executive summary. Management of influenza infection in solid-organ transplant recipients: consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiolo

    abstract：:Solid organ transplant (SOT) recipients are at greater risk than the general population for complications and mortality from influenza infection. We have conducted a systematic review to assess the management and prevention of influenza infection in SOT recipients. Recommendations are provided about the procurement of...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 共识发展会议,杂志文章,实务指引,评审

    doi：10.1016/j.eimc.2013.01.014

    authors： López-Medrano F,Cordero E,Gavaldá J,Cruzado JM,Marcos MÁ,Pérez-Romero P,Sabé N,Gómez-Bravo MÁ,Delgado JF,Cabral E,Carratalá J,Study Group of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases

    更新日期：2013-10-01 00:00:00

  • [Fever of intermediate duration].

    abstract：:Fever of intermediate duration (FID) is defined as non-localized fever occurring in the community, lasting from one to four weeks, and having no diagnostic orientation after basic clinical, analytical and radiological evaluations are completed. These may include careful recording of clinical history, physical examinat...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：10.1016/s0213-005x(03)72904-8

    authors： Rivero A,Zambrana JL,Pachón J

    更新日期：2003-03-01 00:00:00

  • [Staphylococcus aureus infections: new challenges from an old pathogen].

    abstract：:Staphylococcus aureus is a versatile organism with several virulent characteristics and resistance mechanisms at its disposal. It is also a significant cause of a wide range of infectious diseases in humans. S. aureus often causes life-threatening deep seated infections like bacteremia, endocarditis and pneumonia. Whi...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：10.1157/13086552

    authors： Kanafani ZA,Fowler VG Jr

    更新日期：2006-03-01 00:00:00

  • [Detection of pathogenicity factors in strains of classical enteropathogenic Escherichia coli].

    abstract：OBJECTIVE:To determine the number of strains of classic enteropathogenic E. coli (EPEC) that have the eae gene, that is considered a pathogenicity factor. MATERIAL AND METHODS:The presence of the eae gene has been evaluated on 62 EPEC strains of ten different serogroups, isolated from children with gastroenteritis. R...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：

    authors： Frías C,Margall N,Mirelis B,Prats G

    更新日期：1998-06-01 00:00:00

  • [Update on hepatitis C therapy. New drugs, treatment response monitoring and emergence of resistance].

    abstract：:The development of novel direct antiviral agents (DAAs) against hepatitis C virus (HCV) has represented a breakthrough in the treatment of chronic hepatitis C. Telaprevir and boceprevir are the first two protease inhibitor (PI) DAAs to be approved for combination therapy with pegylated interferon (PEG-IFN) and ribavir...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/S0213-005X(13)70113-7

    authors： Chueca Porcuna N,Alvarez Estévez M,Parra Ruiz J,Hernández Quero J,García García F

    更新日期：2013-02-01 00:00:00

  • RDRioMycobacterium tuberculosis strains associated with isoniazid resistance in Northern Mexico.

    abstract：BACKGROUND:It has been established that the genomic background of Mycobacterium tuberculosis may influence disease progression, in particular for the Beijing family and the Latin American and Mediterranean (LAM)/RDRio strains. The purpose of this study was to evaluate the prevalence of the LAM/RDRio genotype in cases o...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/j.eimc.2020.07.003

    authors： Bocanegra-García V,Cortez-de-la-Fuente LJ,Nakamura-López Y,González GM,Rivera G,Palma-Nicolás JP

    更新日期：2020-08-24 00:00:00

  • [Resistance to darunavir].

    abstract：:The resistance profile of darunavir (DRV) was initially explored using pooled week 24 data from POWER 1, 2, and 3 at the recommended dose of DRV (n=467) with the subsequent addition of data from the placebo arm without etravirine (ETR) of DUET 1 and 2 (n=604). The two strongest predictors of virological response were ...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：10.1016/s0213-005x(08)76554-6

    authors： García Deltoro M

    更新日期：2008-10-01 00:00:00

  • Colonization of the nasal airways by Staphylococcus aureus on admission to a major heart surgery operating room: A real-world experience.

    abstract：INTRODUCTION:Nasal swab culture is used to identify Staphylococcus aureus colonization, as this is a major risk factor for surgical site infection (SSI) in patients who are going to undergo major heart surgery (MHS). We determined nasal carriage of S. aureus in patients undergoing MHS by comparing the yield of a conven...

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章

    doi：10.1016/j.eimc.2019.07.013

    authors： Bouza E,Burillo A,de Egea V,Hortal J,Barrio JM,Vicente T,Muñoz P,Pérez-Granda MJ

    更新日期：2020-12-01 00:00:00

  • [Multiresistant Gram-negative bacterial infections: Enterobacteria, Pseudomonas aeruginosa, Acinetobacter baumannii and other non-fermenting Gram-negative bacilli].

    abstract：:Multiresistant Gram-negative bacteria represent a major health problem worldwide. This is related to the severity of the infections they cause, the difficulties for empiric (even directed) treatment, the ease of multiresistance spread, and the absence of new antimicrobial agents active against this group of pathogens....

    journal_title：Enfermedades infecciosas y microbiologia clinica

    pub_type： 杂志文章,评审

    doi：10.1016/j.eimc.2013.03.016

    authors： Fariñas MC,Martínez-Martínez L

    更新日期：2013-06-01 00:00:00