[Longitudinal study on adherence, treatment satisfaction, and effectiveness of once-daily versus twice-daily antiretroviral therapy in a Spanish cohort of HIV-infected patients (CUVA study)].

Abstract:

INTRODUCTION:Adherence is essential for successful antiretroviral therapy (ART), but complex dosing schedules compromise the adherence to and efficacy of this treatment. Once-daily (QD) ART simplifies treatment by lowering the dosing frequency and pill burden. The aim of this study, performed when QD regimens were still limited, was to determine the degree of adherence and patient satisfaction of QD dosing versus twice-daily dosing (BID) of ART. METHODS:Non-interventional, multicenter, longitudinal study, including initial (I), simplification (S), and rescue (R) therapies. Medical visits were performed at baseline, and at 3 and 6 months. A validated, structured questionnaire was used to assess adherence, and a visual analogical scale applied by independent observers was used to assess satisfaction. RESULTS:From May to December 2002, 978 patients were recruited. Average pill burden was 5 in QD vs. 6.1 in BID regimens. Undetectable viral load was achieved at 6 months in 83.7% (I), 87.5% (S), and 57.4% (R) of patients, with no significant differences between QD and BID. Adherence and satisfaction with ART were both significantly better in QD vs. BID regimens: 61.4% vs. 53.2% (P < .05) and 54.4% vs. 41.2% (P < .05), respectively. Multivariate analysis revealed the following variables to account for 1) Adherence to ART (OR; 95% CI): treatment satisfaction (1.53, 1.30-1.80), family support (1.25, 0.98-1.61), years of HIV infection (0.97, 0.94-1.003) and intravenous drug use (0.83, 0.70-0.99); 2) Satisfaction with ART: simplification group (1.70, 1.22-2.34), QD therapy (1.33, 1.13-1.56), years of HIV infection (0.95, 0.93-0.98), and CDC stage C (0.85, 0.73-1.01); and 3) Undetectable viral load: naive group (5.08, 3.14-8.22) and adherence (1.57, 1.13-2.17). CONCLUSION:QD antiretroviral schedules appear to be as effective as BID regimens, with better adherence and treatment satisfaction. This may positively affect treatment efficacy at long-term.

authors

Viciana P,Rubio R,Ribera E,Knobel H,Iribarren JA,Arribas JR,Pérez-Molina JA,Investigadores del Estudio CUVA.

doi

10.1157/13116748

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

127-34

issue

3

eissn

0213-005X

issn

1578-1852

pii

S0213-005X(08)72675-2

journal_volume

26

pub_type

杂志文章,多中心研究
  • [Prudent use of antimicrobial agents and proposals for improvement in veterinary medicine].

    abstract::The alarms that have sounded in the last two decades of the 20(th) century in the feld of antimicrobial resistance in livestock farming have led to the development of various measures that have substantially improved the use of antimicrobial agents in veterinary medicine. These measures mainly involve the implementati...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/S0213-005X(10)70042-2

    authors: Rodríguez LD,Romo MA,Calonge MC,Peña ST

    更新日期:2010-11-01 00:00:00

  • [Variation of the incidence and antibiotic sensitivity of Neisseria gonorrhoeae in a 7-year period].

    abstract:BACKGROUND:The aim of this study was to determine the incidence and antibiotic sensitivity of Neisseria gonorrhoeae versus penicillin, tetracycline, cefoxitin, ceftriaxone and spectinomycin from 1988 to 1994 in the province of Soria (Spain). METHODS:From January 1988 to December 1994, clinical samples of 57 strains of...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Nebreda T,Merino FJ,Campos A,Vázquez M

    更新日期:1996-08-01 00:00:00

  • The use of MALDI-TOF ICMS as an alternative tool for Trichophyton rubrum identification and typing.

    abstract:AIMS:In this study, the potential of matrix-assisted laser desorption/ionization time-of-flight intact cell mass spectrometry (MALDI-TOF ICMS) was investigated for the identification of clinical isolates. The isolates were analyzed at the species and strain level. METHODS:Spectral identification by MALDI-TOF ICMS was ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2013.01.009

    authors: Pereira L,Dias N,Santos C,Lima N

    更新日期:2014-01-01 00:00:00

  • [Subacute endocarditis caused by Actinobacillus actinomycetemcomitans].

    abstract:BACKGROUND:We describe the cases of endocarditis caused by Actinobacillus actinomycetemcomitans (EAA) observed at our hospital. PATIENTS AND METHODS:We revised clinical records and microbiological documents from patients admitted at our hospital, with A. actinomycetemcomitans in blood cultures occurred from 1972-1998....

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Belloch SL,Salavert M,Lacruz J,López-Aldeguer J,Pérez-Bellés C

    更新日期:2000-10-01 00:00:00

  • [Cutaneous tuberculosis: a 15-year descriptive study].

    abstract:INTRODUCTION:Cutaneous tuberculosis has experienced a resurgence following a period of decline. The aim of this study was to determine the clinical and epidemiological characteristics of cutaneous tuberculosis in the Ferrol Healthcare Area (Spain). METHODS:Between 1991-2005, 1139 new cases of tuberculosis were diagnos...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/s0213-005x(08)72692-2

    authors: García-Rodríguez JF,Monteagudo-Sánchez B,Mariño-Callejo A

    更新日期:2008-04-01 00:00:00

  • [Resistance to darunavir].

    abstract::The resistance profile of darunavir (DRV) was initially explored using pooled week 24 data from POWER 1, 2, and 3 at the recommended dose of DRV (n=467) with the subsequent addition of data from the placebo arm without etravirine (ETR) of DUET 1 and 2 (n=604). The two strongest predictors of virological response were ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0213-005x(08)76554-6

    authors: García Deltoro M

    更新日期:2008-10-01 00:00:00

  • [Molecular characterization of the strain causing a shigellosis outbreak in a Madrid school].

    abstract:INTRODUCTION:The aim of this study is to describe a Shigella sonnei outbreak in a school. METHOD:An epidemiological inquiry was performed. Stool samples from 5 patients were cultured. Molecular typing of the isolates was carried out by PFGE, MLST and plasmid analysis. RESULTS:The attack rate was 14.3% (67 students). ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1157/13100466

    authors: Herrera-León S,Alvarez-Castillo Mdel C,Taveira JA,Fernández M,Echeita MA,Sanz JC

    更新日期:2007-04-01 00:00:00

  • [Diagnosis of HIV-1 non-B subtypes and HIV-2].

    abstract::The high genetic diversity of human immunodeficiency virus (HIV) poses a significant challenge to the diagnosis and microbiological characterization of HIV infection. Because of the continual emergence of new variants and the global spread of HIV groups, subtypes and recombinant forms, accurate diagnostic tools are of...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13128783

    authors: Toro C,Amor A,Soriano V

    更新日期:2008-11-01 00:00:00

  • [Duration of antibiotic therapy in intraabdominal infections].

    abstract::The duration of antibiotic treatment in patients with an infectious process is based on empirical considerations and those with intraabdominal infections are no exception. Therefore, the recommended duration of antibiotic therapy in intraabdominal infection is controversial and no consensus has been reached due to the...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0213-005X(10)70030-6

    authors: Maseda E,Gilsanz F

    更新日期:2010-09-01 00:00:00

  • [Lipid alterations and cardiovascular risk associated with antiretroviral therapy].

    abstract::Dyslipidemia is common in HIV-infected patients receiving antiretroviral therapy (ART) and it is often associated with the use of specific antiretroviral drugs. The phenotypic profile can include elevated triglycerides or cholesterol alone, or mixed patterns with varying changes in LDL and HDL lipoproteins, which impl...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13095376

    authors: Masiá-Canuto M,Bernal-Morell E,Gutiérrez-Rodero F

    更新日期:2006-12-01 00:00:00

  • [Analysis of the results of the SEIMC External Quality Control Program. Year 2014].

    abstract::The External Quality Control Program of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) include controls for bacteriology, serology, mycology, parasitology, mycobacteria, virology and molecular microbiology. This article presents the most relevant conclusions and lessons from the 2014 cont...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/S0213-005X(16)30212-9

    authors: Gopegui Bordes ER,Guna Serrano Mdel R,Orta Mira N,Medina González R,Rosario Ovies M,Poveda M,Gimeno Cardona C

    更新日期:2016-07-01 00:00:00

  • [Meropenem in the treatment of surgical intra-abdominal infections].

    abstract::Intraabdominal infections are severe with a high morbidity and mortality which may be produced by multiple causes: perforation of the empty viscera, intestinal inflammatory processes, vascular pictures, abdominal traumatisms as a consequence of surgery. From a microbiologic point of view, different types of gram posit...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Cainzos Fernández M

    更新日期:1997-09-01 00:00:00

  • [Epidemiology and clinical features of Streptococcus pyogenes bacteremia in Cartagena (Murcia, Spain)].

    abstract:INTRODUCTION:A gradual increase in severe cases due to Streptococcus pyogenes or Streptococcus beta-hemolytic group A (SGA), has been detected in the last few decades. METHODS:Retrospective study of bacteremia due to S.pyogenes detected between January 2009 and January 2013 in Cartagena. The annual incidence for sever...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2013.01.010

    authors: Jimeno-Almazán A,Viqueira-Gonzalez M,Alcalde Mdel M,Alcaraz-Vidal B,Vera-Méndez F

    更新日期:2013-08-01 00:00:00

  • Influenza infection in the intensive care unit: Four years after the 2009 pandemic.

    abstract:UNLABELLED:The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied. OBJECTIVE:To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2015.04.004

    authors: Pérez-Carrasco M,Lagunes L,Antón A,Gattarello S,Laborda C,Pumarola T,Rello J,CRIPS investigators.

    更新日期:2016-03-01 00:00:00

  • Executive summary of imported infectious diseases after returning from foreign travel: Consensus document of the Spanish Society for Infectious Diseases and Clinical Microbiology (SEIMC).

    abstract::In a global world, knowledge of imported infectious diseases is essential in daily practice, both for the microbiologist-parasitologist and the clinician who diagnoses and treats infectious diseases in returned travelers. Tropical and subtropical countries where there is a greater risk of contracting an infectious dis...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1016/j.eimc.2017.02.009

    authors: Pérez-Arellano JL,Górgolas-Hernández-Mora M,Salvador F,Carranza-Rodríguez C,Ramírez-Olivencia G,Martín-Echeverría E,Rodríguez-Guardado A,Norman F,Velasco-Tirado V,Zubero-Sulibarría Z,Rojo-Marcos G,Muñoz-Gutierrez J,Ramos-Rincón J

    更新日期:2018-03-01 00:00:00

  • [Data on rilpivirine in treatment-naïve patients. Lessons from ECHO, THRIVE and STaR].

    abstract::Rilpivirine (RPV) is a new, second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) that has been recently approved for use in the initial antiretroviral therapy (ART) of treatment-naïve HIV-infected patients, combined with two nucleoside/nucleotide reverse transcriptase inhibitors (NRTI). The approved...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0213-005X(13)70139-3

    authors: Domingo P,Ribera E

    更新日期:2013-06-01 00:00:00

  • [Polio, the long walk to the endgame].

    abstract::Although the WHO original target date for the global eradication of poliomyelitis was the year 2000 -thanks to vaccination and institutional, public and private, resources for that purpose-, in 2013 the disease remained endemic in three countries, Afghanistan, Pakistan and Nigeria, and some cases were described in fiv...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.eimc.2014.10.005

    authors: García-Sánchez JE,García-Sánchez E,García-Merino E,Fresnadillo-Martínez MJ

    更新日期:2015-12-01 00:00:00

  • [Bacterial resistance and pharmacodynamics as the basis for prescribing antibiotics in respiratory infections].

    abstract::The choice of antibiotic therapy in respiratory tract infections is usually empirical. However, this choice is complicated by the increasing prevalence of resistant strains among the major bacterial pathogens involved in these infections, particularly Streptococcus pneumoniae. The aim of antimicrobial therapy in respi...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1157/13059054

    authors: Aguado-García JM,Martín-Herrero JE,Lumbreras-Bermejo C

    更新日期:2004-04-01 00:00:00

  • Microbiological diagnosis of infections caused by the genus Mycobacterium.

    abstract::Mycobacterial culture has a high sensitivity and is the test of choice for the microbiological diagnosis of tuberculosis and nontuberculous mycobacterial infections. However, the results of this culture require at least 2-3 weeks to obtain positivity. Staining is rapid and can be used as a complementary study, althoug...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2017.11.009

    authors: Samper S,González-Martin J

    更新日期:2018-02-01 00:00:00

  • Current position of viral load versus hepatitis C core antigen testing.

    abstract::Quantification of hepatitis C virus (HCV) RNA (viral load) is the most widely used marker to diagnose and confirm active HCV infection. The HCV core antigen forms part of the internal structure of the virus and, like HCV RNA, its detection also indicates viral replication and presents certain advantages over viral loa...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2020.02.003

    authors: Aguilera A,Alados JC,Alonso R,Eiros JM,García F

    更新日期:2020-01-01 00:00:00

  • [Evaluation of a selective medium for the isolation of Moraxella catarrhalis].

    abstract::The recovery rate of Moraxella catarrhalis in a selective culture medium with acetazolamide and in a conventional blood-agar medium was compared from 1291 samples from the respiratory tract and conjunctivae of children and adults with respiratory and ocular symptomatology. M. catarrhalis was recovered in 215 samples o...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Pozuelo MJ,Ballestero S,Vírseda I,Borrajo E,Saiz T,Meseguer MA

    更新日期:1992-08-01 00:00:00

  • [In vitro activity of voriconazole and three other antifungal agents against dermatophytes].

    abstract:INTRODUCTION:The increase in infections due to dermatophytes in recent years led us to study the effectiveness of new antifungal formulations against these microorganisms. METHODS:The in vitro activity of a new antifungal agent, voriconazole, was compared with three other antifungal agents, itraconazole, fluconazole a...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/s0213-005x(03)72992-9

    authors: Serrano-Martino Mdel C,Chávez-Caballero M,Valverde-Conde A,Claro RM,Pemán J,Martín-Mazuelos E

    更新日期:2003-11-01 00:00:00

  • Could polymerase chain reaction tests on conjunctival swabs be useful to diagnose herpetic keratitis?

    abstract:INTRODUCTION:Diagnosis of HSV-1 keratitis (HK) is frequently based on clinical findings. Invasive specimens (corneal scrapings, biopsies) are required for microbiological diagnosis. METHODS:Corneal scrapings and conjunctival swabs were collected on patients with/without clinical suspicion of HK from 2007 to 2012. RES...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2013.07.005

    authors: Barrado L,Suarez MJ,Pérez-Blázquez E,Otero JR,Folgueira MD

    更新日期:2014-01-01 00:00:00

  • Streptococcus suis spondylodiscitis: 2 new cases and a literature review.

    abstract:INTRODUCTION:Streptococcus suis (S. suis) infection is poorly described zoonosis in our country, which is related with exposure to pigs or their meat. The most common clinical presentation is meningitis, while spinés involvement is rare. METHODS:We report 2 cases of S. suis infection and perform a systematic review of...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:10.1016/j.eimc.2020.08.005

    authors: Romay-Lema EM,Ventura-Valcárcel P,Iñiguez-Vázquez I,García-Pais MJ,García-Garrote F,Rabuñal-Rey R,Alonso MP,Corredoira-Sánchez J

    更新日期:2020-10-14 00:00:00

  • [Lopinavir/ritonavir monotherapy. Possible indications].

    abstract::Monotherapy with LPV/r maintains blocked viral replication when used as a simplification strategy from antiretroviral therapy with a boosted protease inhibitor and two nucleoside analogs in patients with an undetectable viral load for at least 6 months. This simplification strategy can be recommended to patients in th...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/s0213-005x(08)76606-0

    authors: López Aldeguer J

    更新日期:2008-12-01 00:00:00

  • [Analysis of the results of the SEIMC External Quality Control Program, 2007].

    abstract::The External Quality Control Program of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) includes controls for bacteriology, serology, mycology, parasitology, mycobacteria, virology and molecular microbiology. This article presents the most important conclusions and lessons drawn from the 2...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type:

    doi:

    authors: Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).,Guna Serrano Mdel R,Orta Mira N,Ovies M,Gimeno Cardona C,Pérez JL

    更新日期:2008-11-01 00:00:00

  • [Infection by Coxiella burnetii (Q fever)].

    abstract::In spite of being described over 60 years, Q fever is still a little known disease. The exact prevalence is also unknown, but probably the number of cases of Q fever is underestimated. There is much variation in the clinical presentation, including severe forms with a poor prognosis. Acute cases often present as an as...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/S0213-005X(10)70005-7

    authors: Fariñas MT,Collado CM

    更新日期:2010-01-01 00:00:00

  • [Antibody-coated bacteria in the sputum from patients with pneumococcal pneumonia].

    abstract::In the present study an immunofluorescence technique detecting antibody-coated bacteria was evaluated. It was applied to the sputum of seven patients with bacteremic pneumococcal pneumonia to assess its diagnostic usefulness. We conclude that it is a valid, quick and easy technique which permits to differentiate betwe...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Sala-Mateus C,Puig de la Bellacasa J,Torres A,Jiménez de Anta MT,Hojman L,Agustí A

    更新日期:1989-01-01 00:00:00

  • [New anaerobic bacterial species in human infections].

    abstract::This review offers succinct, precise, and complete information based on the available data concerning new anaerobic bacterial species involved in infectious diseases in humans. All hitherto undescribed species, those not previously implicated in clinical conditions, those with confirmed implication in human disease th...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审

    doi:10.1016/j.eimc.2008.09.015

    authors: García-Sánchez JE,José Fresnadillo M,García-Sánchez E

    更新日期:2010-03-01 00:00:00

  • [Practice variation and appropriateness study of antimicrobial therapy for acute pharyngotonsillitis in adults].

    abstract:OBJECTIVE:Infectious pharyngotonsillitis is usually managed with antibiotics by general practitioners and pediatricians both in primary care and the emergency services. In the present work we try to assess the antibiotic variability and appropriateness in the management of acute pharyngotonsillitis among several emerge...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章

    doi:

    authors: Lázaro A,Ochoa C,Inglada L,Eiros JM,Martínez A,Vallano A,Armadans L,Bautista Vidal J,Artero A,Ruiz A,Cerdá T,Guerra L

    更新日期:1999-06-01 00:00:00