Abstract:
INTRODUCTION:Adherence is essential for successful antiretroviral therapy (ART), but complex dosing schedules compromise the adherence to and efficacy of this treatment. Once-daily (QD) ART simplifies treatment by lowering the dosing frequency and pill burden. The aim of this study, performed when QD regimens were still limited, was to determine the degree of adherence and patient satisfaction of QD dosing versus twice-daily dosing (BID) of ART. METHODS:Non-interventional, multicenter, longitudinal study, including initial (I), simplification (S), and rescue (R) therapies. Medical visits were performed at baseline, and at 3 and 6 months. A validated, structured questionnaire was used to assess adherence, and a visual analogical scale applied by independent observers was used to assess satisfaction. RESULTS:From May to December 2002, 978 patients were recruited. Average pill burden was 5 in QD vs. 6.1 in BID regimens. Undetectable viral load was achieved at 6 months in 83.7% (I), 87.5% (S), and 57.4% (R) of patients, with no significant differences between QD and BID. Adherence and satisfaction with ART were both significantly better in QD vs. BID regimens: 61.4% vs. 53.2% (P < .05) and 54.4% vs. 41.2% (P < .05), respectively. Multivariate analysis revealed the following variables to account for 1) Adherence to ART (OR; 95% CI): treatment satisfaction (1.53, 1.30-1.80), family support (1.25, 0.98-1.61), years of HIV infection (0.97, 0.94-1.003) and intravenous drug use (0.83, 0.70-0.99); 2) Satisfaction with ART: simplification group (1.70, 1.22-2.34), QD therapy (1.33, 1.13-1.56), years of HIV infection (0.95, 0.93-0.98), and CDC stage C (0.85, 0.73-1.01); and 3) Undetectable viral load: naive group (5.08, 3.14-8.22) and adherence (1.57, 1.13-2.17). CONCLUSION:QD antiretroviral schedules appear to be as effective as BID regimens, with better adherence and treatment satisfaction. This may positively affect treatment efficacy at long-term.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
Viciana P,Rubio R,Ribera E,Knobel H,Iribarren JA,Arribas JR,Pérez-Molina JA,Investigadores del Estudio CUVA.doi
10.1157/13116748subject
Has Abstractpub_date
2008-03-01 00:00:00pages
127-34issue
3eissn
0213-005Xissn
1578-1852pii
S0213-005X(08)72675-2journal_volume
26pub_type
杂志文章,多中心研究abstract::The alarms that have sounded in the last two decades of the 20(th) century in the feld of antimicrobial resistance in livestock farming have led to the development of various measures that have substantially improved the use of antimicrobial agents in veterinary medicine. These measures mainly involve the implementati...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/S0213-005X(10)70042-2
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abstract:BACKGROUND:The aim of this study was to determine the incidence and antibiotic sensitivity of Neisseria gonorrhoeae versus penicillin, tetracycline, cefoxitin, ceftriaxone and spectinomycin from 1988 to 1994 in the province of Soria (Spain). METHODS:From January 1988 to December 1994, clinical samples of 57 strains of...
journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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abstract:BACKGROUND:We describe the cases of endocarditis caused by Actinobacillus actinomycetemcomitans (EAA) observed at our hospital. PATIENTS AND METHODS:We revised clinical records and microbiological documents from patients admitted at our hospital, with A. actinomycetemcomitans in blood cultures occurred from 1972-1998....
journal_title:Enfermedades infecciosas y microbiologia clinica
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abstract:INTRODUCTION:Cutaneous tuberculosis has experienced a resurgence following a period of decline. The aim of this study was to determine the clinical and epidemiological characteristics of cutaneous tuberculosis in the Ferrol Healthcare Area (Spain). METHODS:Between 1991-2005, 1139 new cases of tuberculosis were diagnos...
journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:10.1016/s0213-005x(08)72692-2
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abstract::The resistance profile of darunavir (DRV) was initially explored using pooled week 24 data from POWER 1, 2, and 3 at the recommended dose of DRV (n=467) with the subsequent addition of data from the placebo arm without etravirine (ETR) of DUET 1 and 2 (n=604). The two strongest predictors of virological response were ...
journal_title:Enfermedades infecciosas y microbiologia clinica
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abstract:INTRODUCTION:The aim of this study is to describe a Shigella sonnei outbreak in a school. METHOD:An epidemiological inquiry was performed. Stool samples from 5 patients were cultured. Molecular typing of the isolates was carried out by PFGE, MLST and plasmid analysis. RESULTS:The attack rate was 14.3% (67 students). ...
journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:10.1157/13128783
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:10.1016/S0213-005X(16)30212-9
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abstract::Intraabdominal infections are severe with a high morbidity and mortality which may be produced by multiple causes: perforation of the empty viscera, intestinal inflammatory processes, vascular pictures, abdominal traumatisms as a consequence of surgery. From a microbiologic point of view, different types of gram posit...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
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更新日期:1997-09-01 00:00:00
abstract:INTRODUCTION:A gradual increase in severe cases due to Streptococcus pyogenes or Streptococcus beta-hemolytic group A (SGA), has been detected in the last few decades. METHODS:Retrospective study of bacteremia due to S.pyogenes detected between January 2009 and January 2013 in Cartagena. The annual incidence for sever...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2013.01.010
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journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:10.1016/j.eimc.2015.04.004
更新日期:2016-03-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 共识发展会议,杂志文章,实务指引
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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abstract::The recovery rate of Moraxella catarrhalis in a selective culture medium with acetazolamide and in a conventional blood-agar medium was compared from 1291 samples from the respiratory tract and conjunctivae of children and adults with respiratory and ocular symptomatology. M. catarrhalis was recovered in 215 samples o...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
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更新日期:1992-08-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2013.07.005
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abstract:INTRODUCTION:Streptococcus suis (S. suis) infection is poorly described zoonosis in our country, which is related with exposure to pigs or their meat. The most common clinical presentation is meningitis, while spinés involvement is rare. METHODS:We report 2 cases of S. suis infection and perform a systematic review of...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2020.08.005
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:
更新日期:2008-11-01 00:00:00
abstract::In spite of being described over 60 years, Q fever is still a little known disease. The exact prevalence is also unknown, but probably the number of cases of Q fever is underestimated. There is much variation in the clinical presentation, including severe forms with a poor prognosis. Acute cases often present as an as...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:10.1016/S0213-005X(10)70005-7
更新日期:2010-01-01 00:00:00
abstract::In the present study an immunofluorescence technique detecting antibody-coated bacteria was evaluated. It was applied to the sputum of seven patients with bacteremic pneumococcal pneumonia to assess its diagnostic usefulness. We conclude that it is a valid, quick and easy technique which permits to differentiate betwe...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::This review offers succinct, precise, and complete information based on the available data concerning new anaerobic bacterial species involved in infectious diseases in humans. All hitherto undescribed species, those not previously implicated in clinical conditions, those with confirmed implication in human disease th...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Infectious pharyngotonsillitis is usually managed with antibiotics by general practitioners and pediatricians both in primary care and the emergency services. In the present work we try to assess the antibiotic variability and appropriateness in the management of acute pharyngotonsillitis among several emerge...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00