Obesity-related adipokines predict patient-reported shoulder pain.

Abstract:

BACKGROUND/AIMS:Increasingly, an inflammatory modulating effect of adipokines within synovial joints is being recognized. To date, there has been no work examining a potential association between the presence of adipokines in the shoulder and patient-reported outcomes. This study undertakes an investigation assessing these potential links. METHODS:50 osteoarthritis patients scheduled for shoulder surgery completed a pre-surgery questionnaire capturing demographic information including validated, patient-reported function (Disabilities of the Arm, Shoulder, and Hand questionnaire) and pain (Short Form McGill Pain Questionnaire) measures. Synovial fluid (SF) samples were analyzed for leptin, adiponectin, and resistin levels using Milliplex MAP assays. Linear regression modeling was used to assess the association between adipokine levels and patient-reported outcomes, adjusted for age, sex, BMI, and disease severity. RESULTS:54% of the cohort was female (n = 27). The mean age (SD) of the sample was 62.9 (9.9) years and the mean BMI (SD) was 28.1 (5.4) kg/m(2). From regression analyses, greater SF leptin and adiponectin levels, but not regarding resistin, were found to be associated with greater pain (p < 0.05). Adipokine levels were not associated with functional outcome scores. CONCLUSIONS:The identified association between shoulder-derived SF leptin and adiponectin and shoulder pain is likely explained by the pro-inflammatory characteristics of the adipokines and represents potentially important therapeutic targets.

journal_name

Obes Facts

journal_title

Obesity facts

authors

Gandhi R,Perruccio AV,Rizek R,Dessouki O,Evans HM,Mahomed NN

doi

10.1159/000357230

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

536-41

issue

6

eissn

1662-4025

issn

1662-4033

pii

000357230

journal_volume

6

pub_type

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