Coexistence of HIV-1 variants with dipeptidic insertion in the reverse transcriptase gene.

Abstract:

:The aim of this communication was to describe the detection of the coexistence of HIV-1 variant with dipeptide insertion between codons 69 and 70 of reverse transcriptase. These variants were isolated from a 16-year-old male patient, undergoing treatment in the city of Marilia, SP, Southeastern Brazil. After confirmation of treatment failure, resistance to antiretroviral drugs testing was performed and two variants with the insertions of the aminoacids Ser-Gly/Ser-Ala at codon 69 of reverse transcriptase were detected, besides the T69S mutation. These insertions have low prevalence, have not been reported in situations of coexistence in Brazil and are related to multidrug resistance, which makes this epidemiological finding relevant.

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Tanikawa AA,Barreto SF,Grotto RM,Pardini MI

doi

10.1590/S0034-8910.2013047004701

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

821-3

issue

4

eissn

0034-8910

issn

1518-8787

pii

S0034-89102013000400821

journal_volume

47

pub_type

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