Abstract:
OBJECTIVE:To determine the severity of dapsone (DDS) acute intoxication - an uncommon medical event - using clinical and laboratory parameters. METHODS:Two hundred and seventy four patients with acute DDS intoxication, aged 1 month to 50 years old, were studied and classified into four age groups. Clinical evaluation was assessed through a protocol and correlated with laboratory parameters. Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp). RESULTS:The most prevalent clinical sign of intoxication was cyanosis, seen in 65.7% of the patients and in 100% of children less than 5 years of age. According to laboratory criteria, MHbp-related severe clinical intoxication was seen in 56.2% and DDSp-related occurred in 58% of the patients. Regarding DDSp, intoxication was considered severe when 20 tablets (100 mg each) were ingested, a median of 29 microg/ml. Regarding MHbp, intoxication was severe when 7.5 tablets were ingested, a median of 38% of the total Hb. The correlation between MHbp and DDSp was statistically significant (n=144, r=0.32, p<0.05). Negative correlation was observed between MHbp and the time elapsed since DDS intake (n=124, r=-0.34, p<0.001). There was also a negative correlation between DDSp and the time elapsed since DDS intake (n=63, r=-0.35, p<0.0001). CONCLUSIONS:Longitudinal analysis showed a significant association between methemoglobinemia and the time elapsed after the intake (t), according to the equation: Dapsonemia = 12.9256 - 0.0682t + 0.234 methemoglobinemia
journal_name
Rev Saude Publicajournal_title
Revista de saude publicaauthors
Carrazza MZ,Carrazza FR,Oga Sdoi
10.1590/s0034-89102000000400013subject
Has Abstractpub_date
2000-08-01 00:00:00pages
396-401issue
4eissn
0034-8910issn
1518-8787pii
S0034-89102000000400013journal_volume
34pub_type
杂志文章abstract:OBJECTIVE:To present an application of logistic regression modelling to estimate ratios of proportions, such as prevalence ratio or relative risk, and the Delta Method to estimate confidence intervals. METHOD:The Delta Method was used because it is appropriate for the estimation of variance of non-linear functions of ...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89101997000100012
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To describe functional capacity changes of elderly during hospitalization and to assess the correlation of these changes at the time of hospital discharge and sociodemographics and clinical variables. METHODS:There were studied 94 patients aged 65 to 94 years admitted to a geriatric-gerontological hospital u...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102004000500011
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To assess inpatient mortality rate of very-low-birth-weight neonates, their clinical progression and factors associated with mortality. METHODS:Longitudinal study including 360 neonates weighing 500-1500 g who were born in Londrina, Southern Brazil, from January 1, 2002 to June 30, 2004. Data were collected ...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102007000600016
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Describe the clinical and epidemiological profile of confirmed cases of yellow fever whose patients were hospitalized in a general hospital for infectious diseases in the State of Rio de Janeiro, Brazil, from March 11, 2017 to June 15, 2018, during a recent outbreak and factors associated with death. METHODS...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.11606/s1518-8787.2019053001434
更新日期:2019-10-21 00:00:00
abstract:OBJECTIVE:To analyze the evolution of the Ministry of Health's spending on drugs. METHODS:The Ministry of Health's total (added) spending on drugs and its (not added) programs' were analyzed between 2002 and 2007. Actions that financed drug acquisition were obtained from the Siga Brasil system and classified according...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102009005000041
更新日期:2009-08-01 00:00:00
abstract::This study assessed the sensitivity, specificity and predictive value of hearing complaints in outpatients attending an university ear, nose and throat clinic. A cross-sectional study was carried out in Canoas, Southern Brazil, from 1999 to 2002. Seven-hundred and ninety-five subjects who underwent the audiometric tes...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102005000600017
更新日期:2005-12-01 00:00:00
abstract::The objective was to describe the current epidemiological status of visceral leishmaniasis in the State of Pernambuco, Northeastern Brazil. For that, a search for scientific production on epidemiology of visceral leishmaniasis in Pernambuco was carried out in electronic databases MEDLINE, SciELO and LILACS. Additional...
journal_title:Revista de saude publica
pub_type: 杂志文章,评审
doi:10.1590/s0034-89102006000300024
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To describe perception of family structures and understanding of a healthy family by Programa Saúde da Família (Family Health Program) team members. METHODS:Research with a qualitative approach, employing the focus group technique, and involving the Program professionals from the city of Campo Bom, Southern ...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102009000100012
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To analyze users' reasons for choosing in vitro fertilization treatment in public or private services and to identify their suggestions for improving fertility treatment. METHODS:A qualitative study using an interpretative approach was conducted. Fifteen semi-structured interviews were conducted with patient...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102012000200017
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To assess life histories of alcohol consumption among women in specialized treatment center for alcohol dependency. METHODS:A qualitative study using a life-history approach was carried out in a sample comprising 13 women being treated in an alcohol and drug treatment and research outpatient clinic from May ...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102005000500018
更新日期:2005-10-01 00:00:00
abstract::Campinas is an important industrial centre in the State of S. Paulo, Brazil. 476 registers filed at the Campinas agency of the Brazilian National Social-Welfore Institution, covering the Campinas, Cosmópolis, Paulínia, Sumaré and Valinhos Counties from 1979 to 1989, were analysed. The information obtained from the Not...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89101993000300003
更新日期:1993-06-01 00:00:00
abstract::A summary of the main steps towards the implementation of anti-HIV testing for pregnant women in the city is presented. Starting from August 1996, voluntary HIV testing became available to pregnant women seen at primary health centers in Ribeirão Preto, SP (Brazil), as part of the Prenatal Care Program. By the end of ...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89101999000600015
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To analyze factors associated with attention-deficit and hyperactivity disorder in children. METHODS:This is a longitudinal study about behavior problems in schoolchildren that was carried out in the city of São Gonçalo (Southeastern Brazil) in 2005. A total of 479 students from public schools was analyzed, ...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102012005000043
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To assess the behavior of induced abortion as a function of certain demographic variables, for the population of fertile women (15 to 49 years old) residing in the Vila Madalena subdistrict S. Paulo (Brazil). MATERIAL AND METHOD:Two population samples were selected. One sample, with 996 women, investigated t...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89101998000100002
更新日期:1998-02-01 00:00:00
abstract::OBJECTIVE To analyze the sociocultural aspects involved in the decision-making process of vaccination in upper-class and highly educated families. METHODS A qualitative approach based on in-depth interviews with 15 couples from the city of Sao Paulo, Southeastern Brazil, falling into three categories: vaccinators, lat...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-8910.2015049005149
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To describe the contraceptive methods used by adult women and the associated socioeconomic and demographic factors. METHODS:Population-based cross-sectional study with 20 to 49-year-old women from São Leopoldo, state of Rio Grande do Sul, in 2015. Three outcomes were considered to analyze the association wit...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.11606/S1518-8787.2019053000861
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To asses how people with mental disorders experience their special needs and interact with the community in public urban places. METHODOLOGY:The research was performed in the city of Passo Fundo, Rio Grande do Sul, Brazil, using ethnography as the theoretical methodological approach. As of the study of one s...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102008000100007
更新日期:2008-02-01 00:00:00
abstract::The relationship between diastolic blood pressure and the variables "total cumulative working time" and "age" was examined by regression analysis. The study was carried out among 839 bus drivers and conductors, users of an occupational health center in Campinas, S. Paulo State, Brazil. The main results were a positive...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89101993000500007
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To assess costs and consequences of prenatal care on perinatal morbidity and mortality. METHODS:Evaluation study using two types of analysis: implementation and efficiency analysis, carried out at 11 Family Health Units in the Recife, Northeastern Brazil, in 2006. The costs were calculated by means of the ac...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102011005000014
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of acute exposure to air pollutants (NO2 and PM10) on hospitalization of adults and older people with cardiovascular diseases in Western São Paulo. METHODS:Daily cardiovascular-related hospitalization data (CID10 - I00 to I99) were acquired by the Department of Informatics of the Braz...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/S1518-8787.2017051006495
更新日期:2017-03-02 00:00:00
abstract:OBJECTIVE:To understand the meanings attributed to self-assessment of health by the elderly. METHODS:Qualitative study performed with 17 elderly individuals (> 70 years of age) of both sexes, living in the city of Bambuí, Southeastern Brazil, in 2008. An anthropological approach based on the model of signs, meanings a...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102010000100017
更新日期:2010-02-01 00:00:00
abstract::OBJECTIVE To evaluate the viability of a professional specialist in intra-hospital committees of organ and tissue donation for transplantation.METHODS Epidemiological, retrospective and cross-sectional study (2003-2011 and 2008-2012), which was performed using organ donation for transplants data in the state of Sao Pa...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/S0034-8910.2015049005770
更新日期:2015-01-01 00:00:00
abstract::For the first time, preferential predation of larvae and pupae of Simuliidae by the crustacean, Aegla platensis Schmitt, 1942, was observed in the field and in the laboratory. Field observations and collections were done in the Carpintaria stream, Dois Irmãos, Country Rio Grande do Sul, Brazil. The possibility of usin...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89101989000300012
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To analyze the limitations of studying dental fluorosis in cross-sectional studies. METHODS:Data from the Oral Health of the Brazilian Population (SBBrasil 2003) and the Brazilian Oral Health Survey (SBBrasil 2010) were used. Epidemiological trends for fluorosis in 12-year-old Brazilians, aspects of the reli...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-8910.2013047004359
更新日期:2013-12-01 00:00:00
abstract::A discussion on the scope of "community" as a category in health promotion by means of its "epistemological sensitivity"--a reasoning tool based upon the epidemiological concept of "sensitivity", adjusted to the epistemological field--was carried out. A brief review of promotional health topics and a short description...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102004000500001
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To evaluate how the Judicial Power safeguards the social right to pharmaceutical assistance as well as the relationships between the legal and political systems to safeguard this right. METHODS:There were assessed decisions in lawsuits of drug supply in the state of São Paulo, Southern Brazil, between 1997 a...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102007000100014
更新日期:2007-02-01 00:00:00
abstract::OBJECTIVE To review the main instruments of functional assessment and health status cited in the literature to evaluate Brazilian workers and verify the compatibility of their items with the core set for professional rehabilitation. METHODS A review of the literature was conducted in the main databases in search of ar...
journal_title:Revista de saude publica
pub_type: 杂志文章,评审
doi:10.11606/s1518-8787.2020054001463
更新日期:2020-01-01 00:00:00
abstract::The growing evidence on the association between consumption of sugar-sweetened beverages, obesity and other chronic diseases has highlighted the need to implement policy actions that go beyond programs exclusively focused on individual responsibility. In order to protect their commercial goals in Latin America, the su...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102011000200022
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) carried out a study to compare and evaluate the practices of protecting, promoting and supporting breastfeeding in public and private hospitals using the "ten steps" of the Hospital Initiative (BFHI) as a reference parameter. ...
journal_title:Revista de saude publica
pub_type: 杂志文章,多中心研究
doi:10.1590/s0034-89102001000500001
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To study trends of dissertation and thesis production in workers' health in Brazil. METHODS:Observation units were dissertations and theses developed by Brazilian researchers in national and foreign graduate programs. Theses and dissertations were identified in previously compiled works, LILACS and Capes dat...
journal_title:Revista de saude publica
pub_type: 杂志文章
doi:10.1590/s0034-89102006000400015
更新日期:2006-08-01 00:00:00