Clinical and laboratory parameters in dapsone acute intoxication.

Abstract:

OBJECTIVE:To determine the severity of dapsone (DDS) acute intoxication - an uncommon medical event - using clinical and laboratory parameters. METHODS:Two hundred and seventy four patients with acute DDS intoxication, aged 1 month to 50 years old, were studied and classified into four age groups. Clinical evaluation was assessed through a protocol and correlated with laboratory parameters. Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp). RESULTS:The most prevalent clinical sign of intoxication was cyanosis, seen in 65.7% of the patients and in 100% of children less than 5 years of age. According to laboratory criteria, MHbp-related severe clinical intoxication was seen in 56.2% and DDSp-related occurred in 58% of the patients. Regarding DDSp, intoxication was considered severe when 20 tablets (100 mg each) were ingested, a median of 29 microg/ml. Regarding MHbp, intoxication was severe when 7.5 tablets were ingested, a median of 38% of the total Hb. The correlation between MHbp and DDSp was statistically significant (n=144, r=0.32, p<0.05). Negative correlation was observed between MHbp and the time elapsed since DDS intake (n=124, r=-0.34, p<0.001). There was also a negative correlation between DDSp and the time elapsed since DDS intake (n=63, r=-0.35, p<0.0001). CONCLUSIONS:Longitudinal analysis showed a significant association between methemoglobinemia and the time elapsed after the intake (t), according to the equation: Dapsonemia = 12.9256 - 0.0682t + 0.234 methemoglobinemia

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Carrazza MZ,Carrazza FR,Oga S

doi

10.1590/s0034-89102000000400013

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

396-401

issue

4

eissn

0034-8910

issn

1518-8787

pii

S0034-89102000000400013

journal_volume

34

pub_type

杂志文章
  • [Ratio of proportions and the use of the delta method for confidence intervals in logistic regression].

    abstract:OBJECTIVE:To present an application of logistic regression modelling to estimate ratios of proportions, such as prevalence ratio or relative risk, and the Delta Method to estimate confidence intervals. METHOD:The Delta Method was used because it is appropriate for the estimation of variance of non-linear functions of ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89101997000100012

    authors: de Oliveira NF,Santana VS,Lopes AA

    更新日期:1997-02-01 00:00:00

  • [Functional impact of hospitalization among elderly patients].

    abstract:OBJECTIVE:To describe functional capacity changes of elderly during hospitalization and to assess the correlation of these changes at the time of hospital discharge and sociodemographics and clinical variables. METHODS:There were studied 94 patients aged 65 to 94 years admitted to a geriatric-gerontological hospital u...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102004000500011

    authors: Siqueira AB,Cordeiro RC,Perracini MR,Ramos LR

    更新日期:2004-10-01 00:00:00

  • [Health care and mortality of very-low-birth-weight neonates].

    abstract:OBJECTIVE:To assess inpatient mortality rate of very-low-birth-weight neonates, their clinical progression and factors associated with mortality. METHODS:Longitudinal study including 360 neonates weighing 500-1500 g who were born in Londrina, Southern Brazil, from January 1, 2002 to June 30, 2004. Data were collected ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102007000600016

    authors: Ribeiro de Carvalho AB,Jamusse de Brito AS,Matsuo T

    更新日期:2007-12-01 00:00:00

  • Yellow fever: profile of cases and factors associated with death in a hospital in the State of Rio de Janeiro, 2017-2018.

    abstract:OBJECTIVE:Describe the clinical and epidemiological profile of confirmed cases of yellow fever whose patients were hospitalized in a general hospital for infectious diseases in the State of Rio de Janeiro, Brazil, from March 11, 2017 to June 15, 2018, during a recent outbreak and factors associated with death. METHODS...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.11606/s1518-8787.2019053001434

    authors: Escosteguy CC,Pereira AGL,Marques MRVE,Lima TRA,Galliez RM,Medronho RA

    更新日期:2019-10-21 00:00:00

  • Ministry of Health's spending on drugs: program trends from 2002 to 2007.

    abstract:OBJECTIVE:To analyze the evolution of the Ministry of Health's spending on drugs. METHODS:The Ministry of Health's total (added) spending on drugs and its (not added) programs' were analyzed between 2002 and 2007. Actions that financed drug acquisition were obtained from the Siga Brasil system and classified according...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102009005000041

    authors: Vieira FS

    更新日期:2009-08-01 00:00:00

  • [Sensitivity, specificity and predictive value of hearing complaints].

    abstract::This study assessed the sensitivity, specificity and predictive value of hearing complaints in outpatients attending an university ear, nose and throat clinic. A cross-sectional study was carried out in Canoas, Southern Brazil, from 1999 to 2002. Seven-hundred and ninety-five subjects who underwent the audiometric tes...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102005000600017

    authors: Marini AL,Halpern R,Aerts D

    更新日期:2005-12-01 00:00:00

  • [Current epidemiological status of visceral leishmaniasis in Northeastern Brazil].

    abstract::The objective was to describe the current epidemiological status of visceral leishmaniasis in the State of Pernambuco, Northeastern Brazil. For that, a search for scientific production on epidemiology of visceral leishmaniasis in Pernambuco was carried out in electronic databases MEDLINE, SciELO and LILACS. Additional...

    journal_title:Revista de saude publica

    pub_type: 杂志文章,评审

    doi:10.1590/s0034-89102006000300024

    authors: Dantas-Torres F

    更新日期:2006-06-01 00:00:00

  • Family Health Program professionals' view on family structures and health implications.

    abstract:OBJECTIVE:To describe perception of family structures and understanding of a healthy family by Programa Saúde da Família (Family Health Program) team members. METHODS:Research with a qualitative approach, employing the focus group technique, and involving the Program professionals from the city of Campo Bom, Southern ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102009000100012

    authors: Gabardo RM,Junges JR,Selli L

    更新日期:2009-02-01 00:00:00

  • Perspectives on access to in vitro fertilization in Portugal.

    abstract:OBJECTIVE:To analyze users' reasons for choosing in vitro fertilization treatment in public or private services and to identify their suggestions for improving fertility treatment. METHODS:A qualitative study using an interpretative approach was conducted. Fifteen semi-structured interviews were conducted with patient...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102012000200017

    authors: Silva S,Barros H

    更新日期:2012-04-01 00:00:00

  • [Alcohol consumption among women: a qualitative analysis].

    abstract:OBJECTIVE:To assess life histories of alcohol consumption among women in specialized treatment center for alcohol dependency. METHODS:A qualitative study using a life-history approach was carried out in a sample comprising 13 women being treated in an alcohol and drug treatment and research outpatient clinic from May ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102005000500018

    authors: Nóbrega Mdo P,Oliveira EM

    更新日期:2005-10-01 00:00:00

  • [Epidemiology of fatal occupational accidents in a metropolitan area of the southeastern region of Brazil, 1979-1989].

    abstract::Campinas is an important industrial centre in the State of S. Paulo, Brazil. 476 registers filed at the Campinas agency of the Brazilian National Social-Welfore Institution, covering the Campinas, Cosmópolis, Paulínia, Sumaré and Valinhos Counties from 1979 to 1989, were analysed. The information obtained from the Not...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89101993000300003

    authors: de Lucca SR,Mendes R

    更新日期:1993-06-01 00:00:00

  • [Availability of voluntary prenatal HIV screening in primary health centers].

    abstract::A summary of the main steps towards the implementation of anti-HIV testing for pregnant women in the city is presented. Starting from August 1996, voluntary HIV testing became available to pregnant women seen at primary health centers in Ribeirão Preto, SP (Brazil), as part of the Prenatal Care Program. By the end of ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89101999000600015

    authors: Neves FR,Passos AD,Gueleri WL

    更新日期:1999-12-01 00:00:00

  • [Family environment and attention-deficit hyperactivity disorder].

    abstract:OBJECTIVE:To analyze factors associated with attention-deficit and hyperactivity disorder in children. METHODS:This is a longitudinal study about behavior problems in schoolchildren that was carried out in the city of São Gonçalo (Southeastern Brazil) in 2005. A total of 479 students from public schools was analyzed, ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102012005000043

    authors: Pires Tde O,Silva CM,Assis SG

    更新日期:2012-08-01 00:00:00

  • Patterns of induced abortion in urban area of southeastern region, Brazil.

    abstract:OBJECTIVE:To assess the behavior of induced abortion as a function of certain demographic variables, for the population of fertile women (15 to 49 years old) residing in the Vila Madalena subdistrict S. Paulo (Brazil). MATERIAL AND METHOD:Two population samples were selected. One sample, with 996 women, investigated t...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89101998000100002

    authors: de Souza e Silva R

    更新日期:1998-02-01 00:00:00

  • Decision-making on childhood vaccination by highly educated parents.

    abstract::OBJECTIVE To analyze the sociocultural aspects involved in the decision-making process of vaccination in upper-class and highly educated families. METHODS A qualitative approach based on in-depth interviews with 15 couples from the city of Sao Paulo, Southeastern Brazil, falling into three categories: vaccinators, lat...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-8910.2015049005149

    authors: Barbieri CL,Couto MT

    更新日期:2015-01-01 00:00:00

  • Social inequalities in the use of contraceptives in adult women from Southern Brazil.

    abstract:OBJECTIVE:To describe the contraceptive methods used by adult women and the associated socioeconomic and demographic factors. METHODS:Population-based cross-sectional study with 20 to 49-year-old women from São Leopoldo, state of Rio Grande do Sul, in 2015. Three outcomes were considered to analyze the association wit...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.11606/S1518-8787.2019053000861

    authors: Gonçalves TR,Leite HM,Bairros FS,Olinto MTA,Barcellos NT,Costa JSDD

    更新日期:2019-04-01 00:00:00

  • [Ethnography of individuals in psychological distress].

    abstract:OBJECTIVE:To asses how people with mental disorders experience their special needs and interact with the community in public urban places. METHODOLOGY:The research was performed in the city of Passo Fundo, Rio Grande do Sul, Brazil, using ethnography as the theoretical methodological approach. As of the study of one s...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102008000100007

    authors: Dalmolin BM,Vasconcellos Mda P

    更新日期:2008-02-01 00:00:00

  • [Diastolic blood pressure associated with accumulated work time among drivers and collectors].

    abstract::The relationship between diastolic blood pressure and the variables "total cumulative working time" and "age" was examined by regression analysis. The study was carried out among 839 bus drivers and conductors, users of an occupational health center in Campinas, S. Paulo State, Brazil. The main results were a positive...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89101993000500007

    authors: Cordeiro R,Lima Filho EC,Fischer FM,Moreira Filho DC

    更新日期:1993-10-01 00:00:00

  • An exploratory study of the costs and consequences of prenatal care in the Family Health Program.

    abstract:OBJECTIVE:To assess costs and consequences of prenatal care on perinatal morbidity and mortality. METHODS:Evaluation study using two types of analysis: implementation and efficiency analysis, carried out at 11 Family Health Units in the Recife, Northeastern Brazil, in 2006. The costs were calculated by means of the ac...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102011005000014

    authors: Vidal SA,Samico IC,Frias PG,Hartz ZM

    更新日期:2011-06-01 00:00:00

  • Effects of air pollution caused by sugarcane burning in Western São Paulo on the cardiovascular system.

    abstract:OBJECTIVE:To evaluate the effects of acute exposure to air pollutants (NO2 and PM10) on hospitalization of adults and older people with cardiovascular diseases in Western São Paulo. METHODS:Daily cardiovascular-related hospitalization data (CID10 - I00 to I99) were acquired by the Department of Informatics of the Braz...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/S1518-8787.2017051006495

    authors: Pestana PR,Braga AL,Ramos EM,Oliveira AF,Osadnik CR,Ferreira AD,Ramos D

    更新日期:2017-03-02 00:00:00

  • Role of autonomy in self-assessment of health by the elderly.

    abstract:OBJECTIVE:To understand the meanings attributed to self-assessment of health by the elderly. METHODS:Qualitative study performed with 17 elderly individuals (> 70 years of age) of both sexes, living in the city of Bambuí, Southeastern Brazil, in 2008. An anthropological approach based on the model of signs, meanings a...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102010000100017

    authors: Fonseca Md,Firmo JO,Loyola Filho AI,Uchôa E

    更新日期:2010-02-01 00:00:00

  • Intra-hospital organ and tissue donation coordination project: cost-effectiveness and social benefits.

    abstract::OBJECTIVE To evaluate the viability of a professional specialist in intra-hospital committees of organ and tissue donation for transplantation.METHODS Epidemiological, retrospective and cross-sectional study (2003-2011 and 2008-2012), which was performed using organ donation for transplants data in the state of Sao Pa...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/S0034-8910.2015049005770

    authors: Silva VS,Moura LC,Leite RF,Oliveira PC,Schirmer J,Roza BD

    更新日期:2015-01-01 00:00:00

  • [Aegla platensis Schmitt, 1942 (Decapoda: Anomura) a predator of immature stages of Simuliidae (Diptera: Culicomorpha)].

    abstract::For the first time, preferential predation of larvae and pupae of Simuliidae by the crustacean, Aegla platensis Schmitt, 1942, was observed in the field and in the laboratory. Field observations and collections were done in the Carpintaria stream, Dois Irmãos, Country Rio Grande do Sul, Brazil. The possibility of usin...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89101989000300012

    authors: Magni ST,Py-Daniel V

    更新日期:1989-06-01 00:00:00

  • [Methodological discussion about prevalence of the dental fluorosis on dental health surveys].

    abstract:OBJECTIVE:To analyze the limitations of studying dental fluorosis in cross-sectional studies. METHODS:Data from the Oral Health of the Brazilian Population (SBBrasil 2003) and the Brazilian Oral Health Survey (SBBrasil 2010) were used. Epidemiological trends for fluorosis in 12-year-old Brazilians, aspects of the reli...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-8910.2013047004359

    authors: Freitas CH,Sampaio FC,Roncalli AG,Moysés SJ

    更新日期:2013-12-01 00:00:00

  • [Health promotion and the epistemological sensitivity of 'community' as a category].

    abstract::A discussion on the scope of "community" as a category in health promotion by means of its "epistemological sensitivity"--a reasoning tool based upon the epidemiological concept of "sensitivity", adjusted to the epistemological field--was carried out. A brief review of promotional health topics and a short description...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102004000500001

    authors: Castiel LD

    更新日期:2004-10-01 00:00:00

  • [Safeguarding of the social right to pharmaceutical assistance in the state of São Paulo, Brazil].

    abstract:OBJECTIVE:To evaluate how the Judicial Power safeguards the social right to pharmaceutical assistance as well as the relationships between the legal and political systems to safeguard this right. METHODS:There were assessed decisions in lawsuits of drug supply in the state of São Paulo, Southern Brazil, between 1997 a...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102007000100014

    authors: Marques SB,Dallari SG

    更新日期:2007-02-01 00:00:00

  • International Classification of Functioning in professional rehabilitation: instruments for assessing work disability.

    abstract::OBJECTIVE To review the main instruments of functional assessment and health status cited in the literature to evaluate Brazilian workers and verify the compatibility of their items with the core set for professional rehabilitation. METHODS A review of the literature was conducted in the main databases in search of ar...

    journal_title:Revista de saude publica

    pub_type: 杂志文章,评审

    doi:10.11606/s1518-8787.2020054001463

    authors: Luna JS,Monteiro GTR,Koifman RJ,Bergmann A

    更新日期:2020-01-01 00:00:00

  • Sponsorship of physical activity programs by the sweetened beverages industry: public health or public relations?

    abstract::The growing evidence on the association between consumption of sugar-sweetened beverages, obesity and other chronic diseases has highlighted the need to implement policy actions that go beyond programs exclusively focused on individual responsibility. In order to protect their commercial goals in Latin America, the su...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102011000200022

    authors: Gómez L,Jacoby E,Ibarra L,Lucumí D,Hernandez A,Parra D,Florindo A,Hallal P

    更新日期:2011-04-01 00:00:00

  • [Assessment of the promotion of breastfeeding in public and private maternities of São Paulo city, Brazil].

    abstract:OBJECTIVE:The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) carried out a study to compare and evaluate the practices of protecting, promoting and supporting breastfeeding in public and private hospitals using the "ten steps" of the Hospital Initiative (BFHI) as a reference parameter. ...

    journal_title:Revista de saude publica

    pub_type: 杂志文章,多中心研究

    doi:10.1590/s0034-89102001000500001

    authors: Toma TS,Monteiro CA

    更新日期:2001-10-01 00:00:00

  • [Workers' health in Brazil: graduate research].

    abstract:OBJECTIVE:To study trends of dissertation and thesis production in workers' health in Brazil. METHODS:Observation units were dissertations and theses developed by Brazilian researchers in national and foreign graduate programs. Theses and dissertations were identified in previously compiled works, LILACS and Capes dat...

    journal_title:Revista de saude publica

    pub_type: 杂志文章

    doi:10.1590/s0034-89102006000400015

    authors: Santana VS

    更新日期:2006-08-01 00:00:00