Abstract:
:The principles of formation, renewal, and eruption of teeth are discussed. Numerous genetic aberrations may affect the formation and eruption of teeth. Cleidocranial dysplasia (CCD), caused by mutations in the runt-related transcription factor 2 (RUNX2) gene, is such a condition. The dental phenotype includes problems in both tooth formation (multiple supernumerary permanent teeth) and tooth eruption (lack of shedding of primary teeth and delayed or arrested eruption of permanent teeth). Clinical studies, animal models, and molecular biology studies have documented that RUNX2 is of paramount importance for osteoblast differentiation, for regression of the dental lamina, and for osteoclastogenesis in the dental follicle and the periodontal ligament. Jensen & Kreiborg, 25 yr ago, proposed a treatment strategy to be applied to patients with CCD, focussing on the importance of early treatment to promote spontaneous eruption of permanent teeth through extraction of primary teeth, surgical removal of supernumerary teeth, and removal of bone covering the first formed permanent teeth at the time when root formation of the permanent teeth has reached half or two-thirds of their final length. This strategy still seems valid and seems to lead to reduction in the burden of care for patients compared with the treatment protocols otherwise recommended.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Kreiborg S,Jensen BLdoi
10.1111/eos.12418subject
Has Abstractpub_date
2018-10-01 00:00:00pages
72-80eissn
0909-8836issn
1600-0722journal_volume
126 Suppl 1pub_type
杂志文章,评审abstract::We assessed the effect of certain oral health-related behaviours on adults' dental health. As part of the Finnish nationwide Health 2000 Survey, dentate subjects, 30-64 yr of age, reported their frequency of consumption of eight sugar- and xylitol-containing products, together with toothbrushing frequency and use of f...
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
pub_type: 杂志文章
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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