Abstract:
:Many neurodegenerative diseases can be misdiagnosed as cerebral palsy. The correct diagnosis is reached when the condition recurs in families or when there are specific clinical signs. The clinical and imaging features of 3 children, from 2 unrelated families, presenting with global developmental delay and dystonia are described, in whom the presence of cyanosis and methemoglobinemia confirmed the diagnosis of recessive hereditary methemoglobinemia type 2. Magnetic resonance imaging showed significant cerebellar atrophy in 2 of the 3 babies. In dark-skinned children, this condition is underdiagnosed, as mild cyanosis is difficult to detect. Screening for methemoglobinemia in children with dystonia, microcephaly, and progressive cerebellar atrophy can be helpful in identifying more cases. As there is no curative treatment for this autosomal recessive condition, the exact diagnosis offers the best chance for prenatal screening, by detecting deficient NADH--cytochrome b5 reductase enzyme activity or by identifying the specific mutation in cultured amniotic fluid cells.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Devadathan K,Sreedharan M,Sarasam S,Colah RB,Kunju PAdoi
10.1177/0883073813512026subject
Has Abstractpub_date
2014-11-01 00:00:00pages
NP139-42issue
11eissn
0883-0738issn
1708-8283pii
0883073813512026journal_volume
29pub_type
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journal_title:Journal of child neurology
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