Abstract:
BACKGROUND:Several growth factors and hyaluronic acid are implicated in fetal scarless healing. Whether these factors can be applied to an adult scar to improve scar characteristics is unknown. OBJECTIVES:This study compared the efficacy and safety of SKN2017B, a proprietary topical cream consisting of selective synthetic recombinant human growth factors and hyaluronic acid in a silicone base containing a specifically formulated silicone cream for postsurgical scar treatment. METHODS:In this prospective, randomized, controlled, double-blinded study, unilateral or bilateral facial or truncal scars in adult surgical patients were randomly treated with SKN2017B or silicone cream. Study investigators, study patients, and 2 independent reviewers assessed improvement in scar characteristics after 4 and 12 weeks of treatment. RESULTS:Forty-nine bilateral and 12 unilateral scars in 45 patients were treated with SKN2017B or silicone. At 12 weeks, investigators rated 74% of scars treated with SKN2017B as showing overall improvement vs 54% of silicone-treated scars, a 73% relative improvement with SKN2017B (P < 0.0001). Patients rated a moderate-to-significant improvement in 85% of SKN2017B-treated scars vs 51% of silicone-treated scars, a 67% relative improvement with SKN2017B (P < 0.001). Independent reviewers rated 87% of scars treated with SKN2017B to be better overall vs 1% of scars treated with silicone (P < 0.0001). There were no tolerability issues or adverse reactions with either cream. CONCLUSIONS:SKN2017B consists of highly selective growth factors within a silicone cream matrix and is well tolerated and effective for surgical scar management. LEVEL OF EVIDENCE: 1:
journal_name
Aesthet Surg Jjournal_title
Aesthetic surgery journalauthors
Zoumalan CI,Tadayon SC,Roostaeian J,Rossi AM,Gabriel Adoi
10.1093/asj/sjy185subject
Has Abstractpub_date
2019-02-15 00:00:00pages
319-330issue
3eissn
1090-820Xissn
1527-330Xpii
5061880journal_volume
39pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:The size and weight of hypertrophied breast can cause both physical and psychological problems. Although the majority of these problems can be solved with breast reduction surgery, the particular problem of development of brassiere strap grooves on the shoulders due to the weight of the breasts cannot be cor...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv007
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Techniques for augmentation mammaplasty commonly involve incisions through at least a portion of the pectoralis major muscle. The effects of implant position and surgical release of the muscle origin have not been thoroughly addressed. OBJECTIVE:In this study the authors report on a group of female athletes...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2004.02.005
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Most aesthetic rhinosurgeons rely on proper photographic documentation of the nose using several different views. The frontal view is probably the most important, but it is also the most demanding. OBJECTIVES:In the frontal view, delicate, 3-dimensional (3D) anatomic structures require special photographic ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sju081
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Facial aging is a degenerative process that impairs contour and angle prominences. Rejuvenation is based on tissue replacement, volumization of the atrophic areas, improvement of flaccidity and cutaneous photoaging. OBJECTIVES:The study aims to apply structural fat grafting to manage volumetric deficits of ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjab016
更新日期:2021-01-16 00:00:00
abstract::Perioperative hyperglycemia is a well-known risk factor for surgical morbidity such as wound healing, infection, and prolonged hospitalization. This association has been reported for a number of surgical subspecialties, including plastic surgery. Specialty-specific guidelines have become increasingly available in the ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjw064
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Regardless of the technique chosen to treat the aging midface, the isolated lateral approach facelift has a limited impact on the midface volume deficit. In an effort to overcome this limitation, modern facial rejuvenation procedures incorporate an additional modality for replenishing the midface volume. Som...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz129
更新日期:2020-03-23 00:00:00
abstract::As injectable products have been introduced and as clinicians have gained experience with them, applications and techniques for injection have evolved, with better cosmetic results, enhanced patient safety, and greatly improved patient satisfaction. Within the past four years, several consensus recommendation panels h...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10378697
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:There is limited evidence available in literature with regard to the complication profile of mastectomy and immediate prosthetic reconstruction in augmented patients. OBJECTIVES:The purpose of this systematic review and meta-analysis is to compare postoperative complications between women with versus withou...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjab028
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Anatomical structures of the nose (including muscles) are elevated, sutured, or reshaped during rhinoplasty. Electromyography and electroneurography are the objective electrophysiologic tests performed for the direct measurement of nasal muscle function. OBJECTIVES:The authors investigate the predictive val...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X11398478
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Recommendations for venous thromboembolism (VTE) prophylaxis have been published in the plastic surgery literature. However, no comprehensive survey of the overall incidence of VTE among plastic surgery patients has been undertaken. OBJECTIVE:This study was performed to determine the incidence of VTE in pla...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2006.07.003
更新日期:2006-09-01 00:00:00
abstract::Ninety-seven women seeking rhytidectomy, blepharoplasty, or both completed two measurements of body image prior to their initial consultation. Results were compared with the normal scores for each of the measurements and with a sample of 32 women seeking rhinoplasty. Results indicated that women seeking rhytidectomy, ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/s1090-820x(97)80004-0
更新日期:1997-07-01 00:00:00
abstract::Rhinoplasty is generally considered to be one of the most challenging, complex, and exciting of all the plastic surgery procedures. In this article, the authors discuss key concepts related to patient evaluation and analysis, as well as techniques and maneuvers that reliably lead to favorable long-term results in rhin...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X10380388
更新日期:2010-07-01 00:00:00
abstract::The different types of sutures utilized in plications and for correction of diastasis during abdominoplasty are reviewed and discussed. Because correction of abdominal deformities also involves fascia and muscle advancement, this review also covers the suture materials used in muscle advancement. The selection of spec...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjy333
更新日期:2019-03-14 00:00:00
abstract::This study was designed to evaluate the short- and long-term histologic consequences of some common skin resurfacing methods. Grids were tattooed on the sides of a Yucatan minipig, the standard model for human skin experiments. Each grid cell was treated with one of the following: Jessner's solution, lactic acid, glyc...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/s1090-820x(98)80018-6
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Autologous fat transplantation for soft tissue augmentation is a commonly used technique without a universally accepted approach. The literature includes a variety of reports describing varying degrees of success or failure. OBJECTIVE:To evaluate the behavior of facial fat grafts in humans with the use of a...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.asj.2008.05.002
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:The clinical results of many studies on platelet-rich plasma (PRP) differ because there is a lack of standardization in PRP preparation and administration, as well as many variables such as PRP preparation methods, platelet concentration, and platelet activation. OBJECTIVES:The aim of this study was to inve...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjab043
更新日期:2021-01-25 00:00:00
abstract:BACKGROUND:Capsular contracture (CC) is the most common complication following primary breast augmentation and one of the most common causes of reoperation. Various studies have suggested certain risk factors, including incision choice. OBJECTIVES:The authors investigate a possible association between the three most c...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X12444267
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Severe blepharoptosis with poor LF has traditionally been managed with exogenous frontalis suspension but complications such as lagophthalmos, infection, rejection were often reported. OBJECTIVES:The function-preserving frontalis orbicularis oculi muscle (FOOM) flap was designed to correct severe blepharopt...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa429
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:With the American College of Obstetricians and Gynecologists reaffirming its 2007 opposition to labiaplasty in 2019, the procedure continues to be controversial. Particular emphasis on pornography as a major influencer on women seeking labiaplasty contributes to its controversy and distracts from other motiv...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz254
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Running parallel with-and perhaps driven by-the huge increase in demand for cosmetic surgery, office-based anesthesia (OBA) is the fastest growing segment of anesthesia practice. Despite this, only 2% of anesthesiology residencies provide exposure to OBA, and many practicing anesthesiologists are not convinc...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.07.012
更新日期:2008-09-01 00:00:00
abstract:Background:Multiple processing and handling methods of autologous fat yield to variations in graft retention and viability, which results in unpredictable clinical outcomes. Objectives:This study aims to understand the skin effects of fat graft preparations that contain a varying ratio of free-lipid and stem-cell-bear...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy111
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Injections are associated with a certain amount of pain, the tolerance of which can vary between individuals. With regard to noninvasive pain control techniques in subcutaneous injections, few studies with adequate levels of evidence and design quality exist to support any specific analgesic method. OBJECTI...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/asj/sjz380
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Although adipose-derived stem cells (ADSCs) and nanofat exert antiaging effects on skin, they contain cellular components that have certain limitations in clinical practice. Cell-free fat extract (Ceffe) is a fraction purified from nanofat through removal of cellular components and lipid remnants that contai...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz306
更新日期:2020-07-13 00:00:00
abstract:Background:Seroma is the most common complication of abdominoplasty. Certain modifications to abdominoplasty may reduce the risk of seroma. Objectives:The authors evaluated the incidence of seroma for 3 abdominoplasty techniques: preservation of Scarpa's fascia, placement of progressive tension (or quilting) sutures, ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,meta分析
doi:10.1093/asj/sjx051
更新日期:2017-10-16 00:00:00
abstract:BACKGROUND:The use of textured breast implants over smooth implants has been widely shown to have a lower incidence of capsular contracture. However, the impact of micropatterning techniques on the incidence of postoperative patient morbidity has not been comprehensively investigated. OBJECTIVES:The authors sought to ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,meta分析
doi:10.1093/asj/sjy178
更新日期:2019-05-16 00:00:00
abstract:BACKGROUND:Patient Reported Outcome Measures (PROM) are increasingly used in healthcare to assess outcomes. The BREAST-Q Implant Surveillance (BREAST-Q IS) is a 5-question Patient Reported Outcome Measure (PROM) used by the Australian Breast Device Registry (ABDR) to monitor the performance of breast devices. Validatio...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa342
更新日期:2020-12-08 00:00:00
abstract::We report two cases of hypersensitivity reactions to Restylane. In the first case, edema developed in a 57-year-old Hispanic woman 10 minutes after injection of 0.7 mL of Perlane around her upper commissures and Botox in her upper face. The patient had been skin tested for Restylane several months earlier and showed n...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2005.07.007
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Breast augmentation is the most popular cosmetic surgery procedure in the United States. Postoperative striae is a known but incompletely understood complication of breast augmentation. OBJECTIVES:The authors investigated their own patient population to discern risk factors for new-onset striae after cosmet...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X14541121
更新日期:2014-09-01 00:00:00
abstract::Laser skin resurfacing has become a well-established treatment for rhytids and epidermal and dermal lesions. We report a rare complication of such treatment: exacerbation of plane warts following laser treatment. A 27-year-old woman underwent outpatient laser treatment at another center to correct skin irregularities ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2006.03.007
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Breast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified a fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression. OBJECTIVES:This work aimed to investigate the role...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz109
更新日期:2020-03-23 00:00:00