ERCC1 expression correlated with EGFR and clinicopathological variables in patients with non-small cell lung cancer. An immunocytochemical study on fine-needle aspiration biopsies samples.

Abstract:

PURPOSE:Expression of ERCC1 has not been well described in fine-needle aspiration biopsies (FNABs) in patients with non-small cell lung cancer (NSCLC). We investigated the expression of ERCC1 in correlation with EGFR expression and clinicopathological factors in patients with NSCLC in order to determine if these play a role in the prognosis of the disease. METHODS:We studied 45 patients, 34 with adenocarcinoma and 11 with squamous cell carcinoma. Of these 45 patients, 35 were males and 10 females, aged between 45 and 83 years, 30 smokers and 15 non-smokers. Eighteen (18) tumors were of stage I, twelve (12) stage II and fifteen (15) stage III. To investigate the expression of ERCC1 and EGFR (scores 0, 1, 2, 3), immunocytochemistry was performed on air dried specimens (FNABs) using monoclonal antibodies by alkaline-phosphatase (APAAP) method. RESULTS:ERCC1 expression was detected in tumors from 27 patients (60%) and EGFR in 10 patients (22.2%). ERCC1 was expressed more frequently in males (65.7%) in patients >65 years old (64%), in smokers (66.7%) and in stage I (66.7%). Negative ERCC1 expression was significantly associated with the presence of EGFR. EGFR was expressed only in adenocarcinomas and more frequently in women (70%) and non smokers (53.3%). CONCLUSIONS:ERCC1 expression was identified as positive (scores 2+ and 3+) in the majority of NSCLCs and seems to be an independent prognostic marker of longer survival. In addition EGFR expression was positive (scores 2+ and 3+) in the minority of NSCLCs and only in adenocarcinomas, more frequently in ERCC1-negative (scores 0 and 1+) tumors, suggesting that it is not an independent prognostic marker for the outcome of the patients suffering from NSCLC.

journal_name

Rev Port Pneumol

authors

Kalogeraki A,Karvela-Kalogeraki I,Tamiolakis D,Petraki P,Saridaki Z,Tzardi M

doi

10.1016/j.rppneu.2013.11.002

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

200-7

issue

4

eissn

0873-2159

issn

2172-6825

pii

S0873-2159(13)00165-7

journal_volume

20

pub_type

杂志文章
  • [Shouldn't the Achilles' heel be on the foot - regarding a clinical case].

    abstract::Clinical suspicion is the bedrock of a thorough clinical work-up, and a review of the clinical files with no definitive diagnosis is a must. Such a review can uncover rare diagnoses, such as Waldenstrom's macroglobulinaemia, a proliferative B-cell disease characterised by medular infiltration and monoclonocal IgM prod...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30292-0

    authors: Cavaco R,Machado C,Gorjão Clara J

    更新日期:2008-11-01 00:00:00

  • [Tuberous sclerosis with pulmonary involvment].

    abstract::Tuberous sclerosis (TS) is a rare, sporadic or autosomal dominant disease characterized by the triad of seizures, mental retardation and angiofibromas. Lungs are rarely involved in TS, and pulmonary involvement is almost always found in females. We report the case of a 52 year -old female, nonsmoker, with a history of...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30032-5

    authors: Ferreira S,Nogueira C,Ferreira D,Neves S,Taveira N

    更新日期:2010-03-01 00:00:00

  • [Lower lung field tuberculosis].

    abstract::Lower lung lobe tuberculosis is less common than the classical radiological forms of pulmonary tuberculosis. However this radiological presentation has a particular relevance in patients with some associated pathological conditions, such as diabetes mellitus, HIV infection and chronic alcoholism. We make a review of t...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30112-4

    authors: Roberto Silva J,Carragoso A,Gil I,Torres S,Gaspar O

    更新日期:2009-01-01 00:00:00

  • [Immigration and tuberculosis. Five year experience].

    abstract::Immigrants are a tuberculosis risk group. In Portugal, in 2000, they had an incidence rate 3.6 times higher than the global incidence, and were native, predominantly, from Angola and Cabo Verde. Being the Chest Disease Center of Venda Nova located in a residential area with a great number of immigrants, most of them l...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30677-2

    authors: Rifes G,Villar M

    更新日期:2003-05-01 00:00:00

  • Non-small cell lung cancer patients treated with erlotinib - Clinical cases.

    abstract::We present four patients with non-small cell lung cancer treated in second and third line with Erlotinib. These are selected patients that obtained a good clinical response. Almost all presented cutaneous side effects. Rev Port Pneumol 2008; XIV (Supl 3): S65-S69. ...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/S0873-2159(15)30324-X

    authors: Dionísio J,Almodôvar T,Matias D,Ferreira P,Mota P,da Costa JD

    更新日期:2008-10-01 00:00:00

  • Study into the use of continuous positive airway pressure in obstructive sleep apnoea-hypopnoea syndrome patients with daytime drowsiness.

    abstract:BACKGROUND:Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a respiratory disorder with high morbidity and mortality. Continuous positive airway pressure (CPAP) is the most commonly prescribed conservative treatment for adults with OSAHS. CPAP therapy normalises or decreases OSAHS symptoms and can reduce and prev...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s2173-5115(09)70106-x

    authors: Ribeiro Franco CM,Cestaro Bonanni J,Jaguaribe AM,Ataíde L Jr

    更新日期:2009-03-01 00:00:00

  • [Unusual diagnosis of tracheal obstruction].

    abstract::Male, 54 years old, with smoking habits. The patient complaints were cough, with bleeding secretions in the previous two months. Because of the persistence of the symptoms, a bronchoscopy was proposed. This exam showed multiple lesions in the trachea, nearly 2 cm above the vocal cords that compromised the airway and d...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:

    authors: Damas C,Fernandes G,Magalhães A,Hespanhol VP

    更新日期:2006-05-01 00:00:00

  • Daytime sleepiness and attention in city bus drivers of two capitals of Brazil.

    abstract::Brazil is one of the world leaders on traffic accidents. The present article studied the excessive daytime sleepiness of public transport drivers in two Brazilian's capitals and their level of attention. It was conducted here a descriptive transversal study of a convenient sample. For the evaluation were used: anthrop...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2013.01.001

    authors: Santos DB,Bittencourt LG,Viegas CA,Gaio E

    更新日期:2013-07-01 00:00:00

  • [Tobacco smoking treatment strategy in COPD].

    abstract::Smoking cessation is one of the most important ways of improving the prognosis of COPD patients. Based on currently available evidence professional health workers should take a proactive and continuous role with smokers, motivating them to stop smoking and providing treatment to aid smoking cessation. The treatment sh...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,评审

    doi:10.1016/s0873-2159(15)30196-3

    authors: Pamplona P,Mendes B

    更新日期:2009-11-01 00:00:00

  • Asthma hospital admission and mortality in mainland Portugal 2000-2007.

    abstract::We conducted a review of asthma hospital admissions in mainland Portugal 2000-2007 to evaluate if one of the aims of the National Asthma Control Programme, a 20% reduction in hospital admissions in children and adolescents in 2007, had been achieved. Using the Health Services Central Administration data base we review...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s2173-5115(09)70119-8

    authors: Bugalho de Almeida A,Covas A,Prates L,Fragoso E

    更新日期:2009-05-01 00:00:00

  • [Role of maximal inspiratory pressure in the evaluation of respiratory muscle strength in asthmatics - Systematic review].

    abstract:UNLABELLED:Asthma is a chronic illness of the airways that can reduce respiratory muscle strength due to the resulting hyperinflation or treatment with corticosteroids. One of the ways to evaluate this respiratory muscular weakness is the Maximal Inspiratory Pressure (PImax). METHODS:A systematic review of the databas...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,评审

    doi:

    authors: Cavalcante Marcelino AM,Justino da Silva H

    更新日期:2010-05-01 00:00:00

  • [Primary pleomorphic sarcoma of the lung].

    abstract::The World Health Organization (WHO) classification of lung cancers ranks the heterogeneous nonsmall cell lung cancer (N-SCLC) group, encompassing sarcoma or sarcoma-containing tumours under one heading: "carcinomas with pleomorphic, sarcomatoid or sarcomatous elements". This group contains entities such as pleomorphic...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,评审

    doi:

    authors: da Matta Abreu M,Marcondes Kozlowski B,de Biasi Cordeiro P,de Sousa A,F Nascimento M,Zamboni M

    更新日期:2008-07-01 00:00:00

  • [Positive bronchoalveolar lavage and quantitative cultures results in suspected late-onset ventilator associated penumonia evaluation--retrospective study].

    abstract:INTRODUCTION:Bronchoalveolar lavage (BAL) with quantitative cultures has been used in order to increase ventilator associated pneumonia (VAP) diagnosis specificity, although the accurate technique for this entity diagnosis remains controversial. OBJECTIVES:To evaluate the influence of using positive BAL and quantitati...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2011.03.002

    authors: Vaz AP,Amorim A,Espinar MJ,Oliveira T,Pereira JM,Paiva JA

    更新日期:2011-05-01 00:00:00

  • Place of death in patients with amyotrophic lateral sclerosis.

    abstract:UNLABELLED:Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disorder that affects motor neurons. Involvement of respiratory muscles causes the failure of the ventilator pump with more or less significant bulbar troubles. ALS course is highly variable but, in most cases, this disease entails a very sig...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.rppneu.2014.03.001

    authors: Escarrabill J,Vianello A,Farrero E,Ambrosino N,Martínez Llorens J,Vitacca M

    更新日期:2014-07-01 00:00:00

  • Well-differentiated fetal adenocarcinoma: a very uncommon malignant lung tumor.

    abstract::Well-differentiated fetal adenocarcinoma (WDFA) is a very uncommon malignant tumor originating in the lung. This report describes the case of a 38-year-old woman with a WDFA treated by surgery. The malignancy is low grade and associated with a good prognosis, and so it is important for clinicians to be aware of and to...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2011.06.003

    authors: El Ouazzani H,Jniene A,Bouchikh M,Achachi L,El Ftouh M,Achir A,El Fassy Fihry MT

    更新日期:2012-01-01 00:00:00

  • End-of-life care in COPD: a survey carried out with Portuguese pulmonologists.

    abstract:INTRODUCTION:End-of-life (EoL) care is a major component in the management of patients with advanced COPD. Patient-physician communication is essential in this process. AIM:To evaluate the practice of Portuguese Pulmonologists in EoL communication and palliative care in COPD. METHODS:An on-line survey was sent to phy...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2014.01.008

    authors: Gaspar C,Alfarroba S,Telo L,Gomes C,Bárbara C

    更新日期:2014-05-01 00:00:00

  • Successful treatment of atelectasis with Dornase alpha in a patient with congenital muscular dystrophy.

    abstract::A 28-year-old neuromuscular patient chronically treated with nocturnal noninvasive ventilation developed pulmonary lobar atelectasis and daytime hypoxemia. Twenty four-hour 5L/min oxygen was begun, while mechanical cough assist aids were applied for seven days. In the following three days, treatment with nebulized Dor...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2012.12.002

    authors: Crescimanno G,Marrone O

    更新日期:2014-01-01 00:00:00

  • Effect of a Pulmonary Rehabilitation Program on the levels of anxiety and depression and on the quality of life of patients with chronic obstructive pulmonary disease.

    abstract:OBJECTIVE:To analyze the effect of a Pulmonary Rehabilitation Program (PRP) on the levels of anxiety and depression and the quality of life of patients with chronic obstructive pulmonary disease. METHOD:Patients with chronic obstructive pulmonary disease (COPD) who completed the PRP of 3 weekly sessions of 60 min dura...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2014.03.007

    authors: da Costa CC,de Azeredo Lermen C,Colombo C,Canterle DB,Machado ML,Kessler A,Teixeira PJ

    更新日期:2014-11-01 00:00:00

  • [Oxidative stress in the neonatal lung disease].

    abstract::Oxidative stress is a risk factor for bronchopulmonary dysplasia in the preterm newborn. Antioxidant defense is impaired in the preterm newborn. Oxidative stress is also involved in cell growth and development. The relationship between oxidative stress and cell growth needs to be understood before antioxidant therapy ...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,评审

    doi:10.1016/s0873-2159(15)30221-x

    authors: Rocha G

    更新日期:2008-01-01 00:00:00

  • Environmental tobacco smoke (ETS) exposure and respiratory morbidity in school age children.

    abstract:INTRODUCTION:Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators ...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:

    authors: Constant C,Sampaio I,Negreiro F,Aguiar P,Silva A,Salgueiro M,Bandeira T

    更新日期:2011-01-01 00:00:00

  • The evaluation of neopterin and antioxidants in long lasting asthma.

    abstract::Asthma is a condition characterised by a chronic immunoinflammatory response to different triggers. Neopterin (NPT) is synthesised by human macrophages upon stimulation with interferon-gamma and is also capable of enhancing the oxidative potential of reactive oxygen species. NPT is useful for the monitoring of cell-me...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s2173-5115(06)70428-6

    authors: Mota Pinto A,Todo-Bom A,Vale Pereira S,Alves V,Santos Rosa M

    更新日期:2006-11-01 00:00:00

  • Physiotherapy in critically ill patients.

    abstract::Prolonged stay in Intensive Care Unit (ICU) can cause muscle weakness, physical deconditioning, recurrent symptoms, mood alterations and poor quality of life. Physiotherapy is probably the only treatment likely to increase in the short- and long-term care of the patients admitted to these units. Recovery of physical a...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.rppneu.2011.06.004

    authors: Ambrosino N,Janah N,Vagheggini G

    更新日期:2011-11-01 00:00:00

  • [The 2009 pandemic influenza A (H1N1) virus infection: experience of a paediatric service at a third-level hospital in Lisbon, Portugal].

    abstract:INTRODUCTION:The 2009 pandemic influenza A (H1N1) (i.e., Pandemic Influenza) is an acute, infectious illness caused by the influenza A (H1N1) 2009 virus. This disease involves respiratory, gastrointestinal and systemic symptoms along with a high incidence occurring at a paediatric age. OBJECTIVE:To study the epidemiol...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2012.01.006

    authors: Malveiro D,Flores P,Sousa E,Guimarães JC

    更新日期:2012-07-01 00:00:00

  • [Comparative analyses between tuberculids and extrapulmonary tuberculosis - Another face for Mycobacterium tuberculosis].

    abstract::The author proposes a comparison of tuberculids and extrapulmonary tuberculosis, highlighting the differences in definition, pathogenesis, clinical manifestations, diagnosis and treatment, proving that they are different expressions of Mycobacterium tuberculosis. The article further discusses updated information on tu...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章,评审

    doi:

    authors: Barroso Pereira JC

    更新日期:2008-05-01 00:00:00

  • [Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].

    abstract::The Authors present a case of acute eosinophilic pneumonia (AEP) associated with severe acute respiratory distress syndrome in a previously healthy young adult, medicated with nitrofurantoin. AEP must be included in the differential diagnosis of community adquired pneumonia, as well as a cause of acute respiratory dis...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30590-0

    authors: Baptista JP,Casanova PC,Sousa JP,Martins PJ,Simões A,Fernandes V,Souto J,Costa JJ,Rebelo A,Carvalho L,Pimentel J

    更新日期:2004-07-01 00:00:00

  • Acinetobacter community-acquired pneumonia in a healthy child.

    abstract::Acinetobacter is involved in a variety of infectious diseases primarily associated with healthcare. Recently there has been increasing evidence of the important role these pathogens play in community acquired infections. We report on the case of a previously healthy child, aged 28 months, admitted for fever, cough and...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/j.rppneu.2011.07.006

    authors: Moreira Silva G,Morais L,Marques L,Senra V

    更新日期:2012-03-01 00:00:00

  • [A child with pulmonary hypertension: from etiological study to therapeutic decisions].

    abstract::Pulmonary hypertension is a rare but devastating disease, with poor prognosis and high mortality. The disease may present as Primary Pulmonary Hypertension where no clear aetiology can be identified, or be related to a variety of underlying conditions. This is a rare disease in paediatric age. The authors present the ...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30505-5

    authors: Guardiano M,Maia AM,Correia C,Azevedo I,Lopes AR,da Silva ED,Moura CS,Marinho A

    更新日期:2005-05-01 00:00:00

  • Smoking habits and awareness of smoking risks depending on academic background in university students.

    abstract:OBJECTIVE:To evaluate smoking habits among a group of medical students and engineering students in order to assess whether, depending on their specific academic background, differences in smoking habits and attitudes towards smoking were present. METHODS:Medical and engineering students from the Oporto University were...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30232-4

    authors: Saleiro S,Damas C,Gomes I

    更新日期:2008-03-01 00:00:00

  • [Congenital lobar emphysema of the newborn. Report of four clinical cases].

    abstract:INTRODUCTION:Congenital lobar emphysema (CLE) is a rare anomaly of lung development that presents in the neonatal period in about 50% of the cases. The authors report four clinical cases of congenital lobar emphysema in the newborn. CLINICAL CASES:Four term newborns, 3M/ 1F, were admitted for respiratory distress star...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:10.1016/s0873-2159(15)30077-5

    authors: Rocha G,Azevedo I,Pinto JC,Moura CS,Guimarães H

    更新日期:2010-09-01 00:00:00

  • [Secondary hypertrophic osteoarthropathy to lung cancer: a case report].

    abstract::The secondary hypertrophic osteoarthropathy is a systemic change that affects the bones, joints and soft tissues and is secondary to any intrathoracic pathology. It is a syndrome of chronic proliferative periostitis of the long bones, clubbing of the fingers of the hands, feet or both, and olyarthritis or polyarthriti...

    journal_title:Revista portuguesa de pneumologia

    pub_type: 杂志文章

    doi:

    authors: da Silva Junior AF,Garcia E,Schorr F,da Silva AB,Medeiros L,da Silva AB

    更新日期:2009-07-01 00:00:00