Tumour ploidy in DNA histograms of pituitary adenomas.

Abstract:

:DNA analysis was performed by flow cytometry (FCM) in 59 cases of different types of pituitary adenomas who underwent microsurgery and were actively followed over a period of 3-6 years. Aneuploid DNA patterns were detected in 12 (20%) cases. Frequency of aneuploidy was highest in prolactin-secreting (36%) as compared to 17% in GH- and 7% in non-secreting adenomas. Some adenoma parameters valid for tumour growth, such as rate of recurrences and mitotic index, were correlated with aneuploidy of the tumour. FCM studies are, therefore, recommended to gain further parameters for the estimation of proliferative activity of pituitary adenomas.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

Lüdecke DK,Beck-Bornholdt HP,Saeger W,Schmidt W

doi

10.1007/BF01403824

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

18-22

issue

1-2

eissn

0001-6268

issn

0942-0940

journal_volume

76

pub_type

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