Epigenome: biosensor of cumulative exposure to chemical and nonchemical stressors related to environmental justice.

Abstract:

:Understanding differential disease susceptibility requires new tools to quantify the cumulative effects of environmental stress. Evidence suggests that social, physical, and chemical stressors can influence disease through the accumulation of epigenetic modifications. Geographically stable epigenetic alterations could identify plausible mechanisms for health disparities among the disadvantaged and poor. Relations between neighborhood-specific epigenetic markers and disease would identify the most appropriate targets for medical and environmental intervention. Complex interactions among genes, the environment, and disease require the examination of how epigenetic changes regulate susceptibility to environmental stressors. Progress in understanding disparities in disease susceptibility may depend on assessing the cumulative effect of environmental stressors on genetic substrates. We highlight key concepts regarding the interface between environmental stress, epigenetics, and chronic disease.

journal_name

Am J Public Health

authors

Olden K,Lin YS,Gruber D,Sonawane B

doi

10.2105/AJPH.2014.302130

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1816-21

issue

10

eissn

0090-0036

issn

1541-0048

journal_volume

104

pub_type

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