Pharmacology and mechanisms of action of new oral anticoagulants.

abstract：:Chloroquine (CQ) induces histamine-independent itch in human and mice. We recently reported the role of intradermal nitric oxide (NO)/cyclic guanosine monophosphate pathway in CQ-evoked scratching in mice. Chloroquine stimulates neuronal nitric oxide synthase (nNOS) activity to over-producing NO in the skin. Sumatript...

journal_title：Fundamental & clinical pharmacology

authors： Haddadi NS,Ostadhadi S,Shakiba S,Afshari K,Rahimi N,Foroutan A,Dehpour AR

更新日期：2018-02-01 00:00:00

abstract：:Zinc is the authoritative metal which is present in our body, and reactive zinc metal is crucial for neuronal signaling and is largely distributed within presynaptic vesicles. Zinc also plays an important role in synaptic function. At cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in ...

journal_title：Fundamental & clinical pharmacology

authors： Prakash A,Bharti K,Majeed AB

更新日期：2015-04-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:The H1-histaminergic agonists 2-pyridylethylamine (2-PEA) and 2-methylhistamine relaxed potassium-constricted, perfused, rabbit middle cerebral arteries at low concentrations (3 x 10(-11) to 3 x 10(-8) M) and constricted them at high concentrations (3 x 10(-7) to 3 x 10(-4) M). The relaxation and the contraction were ...

journal_title：Fundamental & clinical pharmacology

authors： Ea Kim L,Sercombe R,Oudart N

更新日期：1988-01-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a common infectious disease in the world. Two percent of the patients with chronic HBV infection will develop cirrhosis each year, and will die prematurely from cirrhosis or hepatocellular carcinoma. So far interferon alfa and lamivudine are the only effective drugs. Interf...

journal_title：Fundamental & clinical pharmacology

authors： Ormeci N

更新日期：2003-12-01 00:00:00

abstract：:Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

journal_title：Fundamental & clinical pharmacology

authors： Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

更新日期：2019-06-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic cough and airway hyperresponsiveness. The aim of this work was to assess in pigs the effects of bradykinin and tac...

journal_title：Fundamental & clinical pharmacology

authors： Moreaux B,Advenier C,Gustin P

更新日期：2001-02-01 00:00:00

abstract：:The aim of this study was to characterize the model of oxidative stress consisting in the infection of malonate (3 mumol), an inhibitor of mitochondrial complex II, in the rat striatum. The striatal concentrations of both the reduced and oxidized forms of glutathione (the major endogenous antioxidant) were determined ...

journal_title：Fundamental & clinical pharmacology

authors： Paucard A,Besson VC,Plotkine M,Margaill I

更新日期：2005-02-01 00:00:00

abstract：:The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC-MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery. Dextromoramide was rapidly absorbed from the gastrointesti...

journal_title：Fundamental & clinical pharmacology

authors： Pagani I,Barzaghi N,Crema F,Perucca E,Ego D,Rovei V

更新日期：1989-01-01 00:00:00

abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

journal_title：Fundamental & clinical pharmacology

authors：

更新日期：1997-01-01 00:00:00

abstract：:Erythropoietin (EPO), the principal hematopoietic cytokine produced by the kidney and the liver in fetuses, regulates mammalian erythropoiesis and exhibits diverse cellular effects in non-hematopoietic tissues. The introduction of recombinant human EPO (rhEPO) has marked a significant advance in the management of anem...

journal_title：Fundamental & clinical pharmacology

authors： Joyeux-Faure M,Godin-Ribuot D,Ribuot C

更新日期：2005-08-01 00:00:00

abstract：:A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti-inflammatory of 4-PSQ. For this reason, the first objective of this study was to expand our previous findings by investig...

journal_title：Fundamental & clinical pharmacology

authors： Silva VDG,Reis AS,Pinz MP,da Fonseca CAR,Duarte LFB,Roehrs JA,Alves D,Luchese C,Wilhelm EA

更新日期：2017-10-01 00:00:00

abstract：:The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to af...

journal_title：Fundamental & clinical pharmacology

authors： Noize P,Sauer M,Bruneval P,Moreau M,Pathak A,Bagheri H,Montastruc JL

更新日期：2006-12-01 00:00:00

abstract：:The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...

journal_title：Fundamental & clinical pharmacology

authors： Meyer UA

更新日期：1990-01-01 00:00:00

abstract：:In addition to their direct effects on cardiac contractility, a number of positive inotropic agents also induce, through direct peripheral vasodilation, a reduction in afterload which is of major importance in their beneficial effects in the treatment of congestive heart failure. However, the induced increase in cardi...

journal_title：Fundamental & clinical pharmacology

authors： Gosgnach M,Gérard JL,Berdeaux A,Giudicelli JF

更新日期：1991-01-01 00:00:00

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:Thalidomide, a well-known immunomodulatory compound, has an anti-angiogenic activity, which may be utilized for the treatment of angiogenesis-related diseases such as hemangioendothelioma. The aim of the present study was to investigate both the antitumor role of thalidomide on hemangioendothelioma and the underlying ...

journal_title：Fundamental & clinical pharmacology

authors： Guo L,Wan Z,Xu B,Ren L,Liu H,Song N,Liu L

更新日期：2019-12-01 00:00:00

abstract：:To date, no reports of hypersensitivity reactions (HSRs) among nonsteroidal anti-inflammatory drugs (NSAIDs) according to cyclo-oxygenase (COX) selectivity and chemical groups have been published in a single study. The present study assessed the reporting frequency of HSRs for NSAIDs based on their relative inhibitory...

journal_title：Fundamental & clinical pharmacology

authors： Bakhriansyah M,Meyboom RHB,Souverein PC,de Boer A,Klungel OH

更新日期：2019-10-01 00:00:00

abstract：:In experiments in vivo, we studied whether the endothelial dysfunction induced by nitric oxide (NO) synthesis inhibition is simultaneously or sequentially manifested as a reduced level of endothelium-dependent agonist-induced vasodilatation, an increased responsiveness to vasoconstrictors, and hypertension. Vascular r...

journal_title：Fundamental & clinical pharmacology

authors： López RM,Pérez T,Castillo C,Castillo MC,Castillo EF

更新日期：2011-06-01 00:00:00

abstract：:HMG CoA reductase inhibitors (statins) have an established place in the treatment of coronary artery disease. However, their role in the treatment of heart failure (HF), including HF due to coronary artery disease, has been controversial since beneficial as well as possible harmful effects may occur. Several recent st...

journal_title：Fundamental & clinical pharmacology

authors： Gullestad L,Oie E,Ueland T,Yndestad A,Aukrust P

更新日期：2007-11-01 00:00:00

abstract：:The aims of this study were: (i) To investigate the activity of recombinant AMPs HNP-1 and hBD-1 in combination with cefotaxime against Staphylococcus aureus strains (MSSA and MRSA) in vitro using checkerboard method; (ii) To investigate the activity of HNP-1 and hBD-1 encapsulated in silicon nanoparticles (niosomes) ...

journal_title：Fundamental & clinical pharmacology

authors： Bolatchiev A,Baturin V,Bazikov I,Maltsev A,Kunitsina E

更新日期：2020-02-01 00:00:00

abstract：:Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant-like action o...

journal_title：Fundamental & clinical pharmacology

authors： Melo CT,de Carvalho AM,Moura BA,Teixeira CP,Vasconcelos LF,Feitosa ML,de Oliveira GV,Barbosa-Filho JM,Chavez Gutierrez SJ,de França Fonteles MM,Vasconcelos SM,de Sousa FC

更新日期：2013-02-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00

abstract：:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

更新日期：2005-10-01 00:00:00

abstract：:The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. Although CGP 37849 was the more potent compound, both antago...

journal_title：Fundamental & clinical pharmacology

authors： D'Hooge R,Raes A,Van de Vijver G,Van Bogaert PP,De Deyn PP

更新日期：1999-01-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:The third generation aromatase inhibitors are currently the drugs of choice for the treatment of early and advanced breast cancer in postmenopausal women. One of the significant limiting factor during therapy is their negative impact on bone health. In this study, we compared the effects of a nonsteroidal (letrozole) ...

journal_title：Fundamental & clinical pharmacology

authors： Kalam A,Talegaonkar S,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:The prevalence of end stage renal disease (ESRD) is growing in western countries. Patients with ESRD are more frequently elderly and diabetic and are exposed to very high cardiovascular morbidity and mortality. The main aim of the FOSIDIAL study is to assess the efficacy and safety of fosinopril, an angiotensin conver...

journal_title：Fundamental & clinical pharmacology

authors： Zannad F,Kessler M,Grünfeld JP,Thuilliez C,FOSInopril in DIALysis Investigators.

更新日期：2002-10-01 00:00:00

abstract：:Potentiation of opioid analgesia by endothelin-A (ET(A)) receptor antagonist, BMS182874, and imidazoline receptor/α₂-adrenoceptor agonists such as clonidine and agmatine are well known. It is also known that agmatine blocks morphine hyperthermia in rats. However, the effect of agmatine on morphine or oxycodone hypothe...

journal_title：Fundamental & clinical pharmacology

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2013-10-01 00:00:00

abstract：:Prostaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES. Among them, m...

journal_title：Fundamental & clinical pharmacology

authors： Kojima F,Kato S,Kawai S

更新日期：2005-06-01 00:00:00