Abstract:
:Plantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. To identify genetic loci associated with plantar fascial disorders, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 21,624 cases of plantar fascial disorders and 80,879 controls. One indel (chr5:118704153:D) and one SNP (rs62051384) showed an association with plantar fascial disorders at genome-wide significance (p<5×10-8) with small effects (odds ratios=0.93 and 1.07 per allele, respectively). The indel chr5:118704153:D is located within TNFAIP8 (encodes a protein induced by TNF alpha) and rs62051384 is located within WWP2 (which is involved in proteasomal degradation). These DNA variants may be informative in explaining why some individuals are at higher risk for plantar fascial disorders than others.
journal_name
Int J Sports Medjournal_title
International journal of sports medicineauthors
Kim SK,Ioannidis JPA,Ahmed MA,Avins AL,Kleimeyer JP,Fredericson M,Dragoo JLdoi
10.1055/s-0044-100280subject
Has Abstractpub_date
2018-04-01 00:00:00pages
314-321issue
4eissn
0172-4622issn
1439-3964journal_volume
39pub_type
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