Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging.

abstract：PURPOSE:According to the updated WHO classification of gliomas with its emphasis on molecular parameters, tumours with an IDH-wildtype status have a dismal prognosis. To ensure timely adjustment of treatment, demand for non-invasive prediction methods is high. 18F-FET PET has been shown to be an important diagnostic to...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vettermann F,Suchorska B,Unterrainer M,Nelwan D,Forbrig R,Ruf V,Wenter V,Kreth FW,Herms J,Bartenstein P,Tonn JC,Albert NL

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:The study serves to optimise conditions for multi-pinhole SPECT small animal imaging of (123)I- and (99m)Tc-labelled radiopharmaceuticals with different distributions in murine heart and brain and to investigate detection and dose range thresholds for verification of differences in tracer uptake. METHODS:A Tri...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pissarek M,Meyer-Kirchrath J,Hohlfeld T,Vollmar S,Oros-Peusquens AM,Flögel U,Jacoby C,Krügel U,Schramm N

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. METHODS:A cohort of patients who participated in the EVINCI protocol underwent an eva...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Berti V,Sciagrà R,Neglia D,Pietilä M,Scholte AJ,Nekolla S,Rouzet F,Pupi A,Knuuti J

更新日期：2016-07-01 00:00:00

abstract：:Physiologically increased pancreatic uptake at the head/uncinate process is observed in more than one-third of patients after injection of one of the three (68)Ga-labelled octreotide-based peptides used for somatostatin (sst) receptor (r) imaging. There are minor differences between these (68)Ga-sstr-binding peptides ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Virgolini I,Gabriel M,Kroiss A,von Guggenberg E,Prommegger R,Warwitz B,Nilica B,Roig LG,Rodrigues M,Uprimny C

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:The aims of this study were (1) to evaluate FDG PET/CT and CT for the detection of axillary lymph node metastases in breast cancer (BC) patients and (2) to evaluate FDG PET/CT as a pre-test for the triage to sentinel lymph node biopsy (SLNB) versus axillary lymph node dissection (ALND). METHODS:The sensitivity...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Heusner TA,Kuemmel S,Hahn S,Koeninger A,Otterbach F,Hamami ME,Kimmig KR,Forsting M,Bockisch A,Antoch G,Stahl A

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:We report the biodistribution and radiation dosimetry of an integrin αvβ3 specific PET tracer (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2) (denoted as (18)F-Alfatide II). We also assessed the value of (18)F-Alfatide II in patients with brain metastases. METHODS:A series of torso (from the skull to the thigh) static image...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yu C,Pan D,Mi B,Xu Y,Lang L,Niu G,Yang M,Wan W,Chen X

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Radionuclide renography with angiotensin converting enzyme (ACE) inhibition plays an important role in the diagnosis of haemodynamically significant renal artery stenosis. Angiotensin receptor antagonists inhibit the renin angiotensin system at different levels from ACE inhibitors by selectively blocking the bi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Günay EC,Oztürk MH,Ergün EL,Altun B,Salanci BV,Uğur O,Cil B,Hekimoğlu B,Caner B

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:It is a matter of controversy whether prophylactic lymph node dissection improves prognosis and survival in papillary thyroid carcinoma (PTC) patients without suspicion of lymph node metastases either clinically or on ultrasonography. It is possible that in such patients the use of lymphatic mapping and sentine...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pelizzo MR,Rubello D,Boschin IM,Piotto A,Paggetta C,Toniato A,De Salvo GL,Giuliano A,Mariani G,Casara D

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:The aim of the present study is to prospectively evaluate the prognostic value of previously defined [(18)F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) criteria of early metabolic response in patients with locally advanced rectal cancer (LARC) after long-term follow-up. METHODS:Forty-two ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Avallone A,Aloj L,Caracò C,Delrio P,Pecori B,Tatangelo F,Scott N,Casaretti R,Di Gennaro F,Montano M,Silvestro L,Budillon A,Lastoria S

更新日期：2012-12-01 00:00:00

abstract：:This proposal for standardization of (123)I-metaiodobenzylguanidine (iobenguane, MIBG) cardiac sympathetic imaging includes recommendations for patient information and preparation, radiopharmaceutical, injected activities and dosimetry, image acquisition, quality control, reconstruction methods, attenuation, scatter a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Flotats A,Carrió I,Agostini D,Le Guludec D,Marcassa C,Schäfers M,Somsen GA,Unlu M,Verberne HJ,EANM Cardiovascular Committee.,European Council of Nuclear Cardiology.

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Several patients experience unexplained persistent symptoms after SARS-CoV-2 recovering. We aimed at evaluating if 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was able to demonstrate a persistent inflammatory process. METHODS:Recovered adult COVID-19 patients, who complained unexplained persisting symptoms for ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sollini M,Ciccarelli M,Cecconi M,Aghemo A,Morelli P,Gelardi F,Chiti A

更新日期：2020-10-30 00:00:00

abstract：PURPOSE:Vascular stiffness may potentially be used as a screening tool to identify asymptomatic patients with diabetes with abnormal myocardial perfusion. The purpose of this study was therefore to determine the association between vascular stiffness, measured in term of pulse wave velocity (PWV) and augmentation index...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Roos CJ,Djaberi R,Schuijf JD,de Koning EJ,Rabelink TJ,Smit JW,Pereira AM,Al Younis I,van der Hiel B,Scholte AJ,Bax JJ,Jukema JW

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The pattern expression score (PES), i.e., the degree to which a pathology-related pattern is present, is frequently used in FDG-brain-PET analysis and has been shown to be a powerful predictor of conversion to Alzheimer's disease (AD) in mild cognitive impairment (MCI). Since, inevitably, the PES is affected ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Blum D,Liepelt-Scarfone I,Berg D,Gasser T,la Fougère C,Reimold M,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO) are a novel therapy option for acute myeloid leukaemia (AML). Key prognostic factors for patients with AML are high CD33 expression on the leukaemic cells and the ability to overcome mechanisms of resistan...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Petrich T,Korkmaz Z,Krull D,Frömke C,Meyer GJ,Knapp WH

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Our aim was to assess the prognostic and predictive value of somatostatin receptor 2 (sstr2) in neuroendocrine tumors (NETs). METHODS:We established a tissue microarray and imaging database from NET patients that received sstr2-targeted radiopeptide therapy with yttrium-90-DOTATOC, lutetium-177-DOTATOC or alte...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brunner P,Jörg AC,Glatz K,Bubendorf L,Radojewski P,Umlauft M,Marincek N,Spanjol PM,Krause T,Dumont RA,Maecke HR,Müller-Brand J,Briel M,Schmitt A,Perren A,Walter MA

更新日期：2017-03-01 00:00:00

abstract：:Chronic cigarette smoking alters coronary vascular endothelial response. To determine whether altered response also occurs in young individuals without manifest coronary disease we quantified coronary blood flow at rest, following adenosine vasodilator stress and during the cold pressor test in healthy young smokers. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Iwado Y,Yoshinaga K,Furuyama H,Ito Y,Noriyasu K,Katoh C,Kuge Y,Tsukamoto E,Tamaki N

更新日期：2002-08-01 00:00:00

abstract：:We assessed the accuracy of brain perfusion single-photon emission computed tomography (SPECT) in discriminating between patients with probable Alzheimer's disease (AD) at the very early stage and age-matched controls before and after partial volume correction (PVC). Three-dimensional MRI was used for PVC. We randomly...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kanetaka H,Matsuda H,Asada T,Ohnishi T,Yamashita F,Imabayashi E,Tanaka F,Nakano S,Takasaki M

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:This study aimed to establish an effective nomogram to predict primary distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC) to guide the application of PET/CT. METHODS:In total, 3591 patients with pathologically confirmed NPC were consecutively enrolled. The nomogram was constructed based on...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Xiao BB,Lin DF,Sun XS,Zhang X,Guo SS,Liu LT,Luo DH,Sun R,Wen YF,Li JB,Lv XF,Han LJ,Yuan L,Liu SL,Tang QN,Liang YJ,Li XY,Guo L,Chen QY,Fan W,Mai HQ,Tang LQ

更新日期：2021-01-08 00:00:00

abstract：:Organ residence times were calculated for diagnostic intakes of (99m)Tc pertechnetate, 2,3-dimercaptosuccinic acid (DMSA), diethylene triamine penta-acetic acid (DTPA), hydroxymethylene diphosphonate (HDP), macroaggregated albumin (MAA) and mercapto-acetyltriglycine (MAG(3)) during the 1st and 3rd stages of pregnancy ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Saunders M,Palmer M,Preece A,Millard R

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Ischemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF)...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sciagrà R,Calabretta R,Cipollini F,Passeri A,Castello A,Cecchi F,Olivotto I,Pupi A

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between coronary artery calcium (CAC) and coronary vasodilator function. METHODS:We evaluated 136 patients without known coronary artery disease (CAD) undergoing vasodilator stress (82)Rb PET/CT and CAC scoring who showed normal myocardial perfusion. The CAC score, resting and hype...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Curillova Z,Yaman BF,Dorbala S,Kwong RY,Sitek A,El Fakhri G,Anagnostopoulos C,Di Carli MF

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:PSMA ligand imaging with hybrid PET/MRI scanners could be an integral part of the clinical routine in the future. However, the first study about this novel method revealed a severe photopenic artifact ("halo artifact") around the urinary bladder causing significantly reduced tumor visibility. The aim of this ev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Afshar-Oromieh A,Wolf M,Haberkorn U,Kachelrieß M,Gnirs R,Kopka K,Schlemmer HP,Freitag MT

更新日期：2017-09-01 00:00:00

abstract：:As measurement of glomerular filtration rate (GFR) is now generally the responsibility of departments of nuclear medicine, it is important for nuclear medicine physicians and scientists to understand the pharmacokinetics of the indicators and radiotracers that are used, generally known as filtration markers. The singl...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Peters AM

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Carimas (Cardiac Image Analysis System) is a new software package developed at the Turku PET Centre for the quantitation of PET studies of the heart with a broad range of tracers. The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nesterov SV,Han C,Mäki M,Kajander S,Naum AG,Helenius H,Lisinen I,Ukkonen H,Pietilä M,Joutsiniemi E,Knuuti J

更新日期：2009-10-01 00:00:00

abstract：:The introduction of multislice computed tomography (MSCT) has allowed non-invasive coronary angiography. Although widely applied, extensive information on technical details of the technique is lacking. This survey offers detailed information on patient preparation, data acquisition, reconstruction and interpretation. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Cademartiri F,Schuijf JD,Mollet NR,Malagutti P,Runza G,Bax JJ,de Feyter PJ

更新日期：2005-11-01 00:00:00

abstract：:The goal of this study was to perform a systematic, semi-quantitative analysis of limbic perfusion in patients with Alzheimer's disease (AD) using coregistered single-photon emission tomography (SPET) images aligned to magnetic resonance (MR) images. Limbic perfusion in 40 patients with mild to moderate AD was compare...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Callen DJ,Black SE,Caldwell CB

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Familial adenomatous polyposis (FAP) is characterised by colonic and duodenal adenomatous polyps that carry a risk of malignant transformation. Malignant degeneration of duodenal adenomas is difficult to detect. We speculated that 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) might...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Kouwen MC,Drenth JP,van Krieken JH,van Goor H,Friederich P,Oyen WJ,Nagengast FM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) radioligands specific to α7 nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer's disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α7-nAChR-specific ra...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hillmer AT,Zheng MQ,Li S,Scheunemann M,Lin SF,Holden D,Labaree D,Ropchan J,Teodoro R,Deuther-Conrad W,Carson RE,Brust P,Huang Y

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To quantify the severity of 2019 novel coronavirus disease (COVID-19) on chest CT and to determine its relationship with laboratory parameters. METHODS:Patients with real-time fluorescence polymerase chain reaction (RT-PCR)-confirmed COVID-19 between January 01 and February 18, 2020, were included in this stud...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zhang B,Zhang J,Chen H,Chen L,Chen Q,Li M,Chen Z,You J,Yang K,Zhang S

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Iterative reconstruction methods based on ordered-subset expectation maximisation (OSEM) has replaced filtered backprojection (FBP) in many clinical settings owing to the superior image quality. Whether OSEM is as accurate as FBP in quantitative positron emission tomography (PET) is uncertain. We compared the a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Søndergaard HM,Madsen MM,Boisen K,Bøttcher M,Schmitz O,Nielsen TT,Bøtker HE,Hansen SB

更新日期：2007-03-01 00:00:00