The prognostic and predictive value of sstr2-immunohistochemistry and sstr2-targeted imaging in neuroendocrine tumors.

abstract：PURPOSE:The purpose of this study was to evaluate the usefulness of L-4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) as a tumor-specific probe, in comparison to 18F-FDG and 11C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Watabe T,Ikeda H,Nagamori S,Wiriyasermkul P,Tanaka Y,Naka S,Kanai Y,Hagiwara K,Aoki M,Shimosegawa E,Kanai Y,Hatazawa J

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue. METHODS:Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, ap...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Fuchs TA,Ghadri JR,Stehli J,Gebhard C,Kazakauskaite E,Klaeser B,Gaemperli O,Fiechter M,Kaufmann PA

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Myocardial perfusion with PET/CT has advantages over conventional SPECT. We describe our initial European experience using (82)Rubidium-PET/CT, as part of a clinical myocardial perfusion service. METHODS:We studied the first 100 patients (64 male; 36 female, mean age = 60: SD +/-12.5y, mean body mass index = 3...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Groves AM,Speechly-Dick ME,Dickson JC,Kayani I,Endozo R,Blanchard P,Shastry M,Prvulovich E,Waddington WA,Ben-Haim S,Bomanji JB,McEwan JR,Ell PJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:According to the updated WHO classification of gliomas with its emphasis on molecular parameters, tumours with an IDH-wildtype status have a dismal prognosis. To ensure timely adjustment of treatment, demand for non-invasive prediction methods is high. 18F-FET PET has been shown to be an important diagnostic to...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vettermann F,Suchorska B,Unterrainer M,Nelwan D,Forbrig R,Ruf V,Wenter V,Kreth FW,Herms J,Bartenstein P,Tonn JC,Albert NL

更新日期：2019-11-01 00:00:00

abstract：:This proposal for standardization of (123)I-metaiodobenzylguanidine (iobenguane, MIBG) cardiac sympathetic imaging includes recommendations for patient information and preparation, radiopharmaceutical, injected activities and dosimetry, image acquisition, quality control, reconstruction methods, attenuation, scatter a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Flotats A,Carrió I,Agostini D,Le Guludec D,Marcassa C,Schäfers M,Somsen GA,Unlu M,Verberne HJ,EANM Cardiovascular Committee.,European Council of Nuclear Cardiology.

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:While methods for imaging tumor hypoxia with positron emission tomography (PET) have been developed, optimal methods for interpreting and utilizing these datasets in the clinic remain unclear. In this study, we analyzed hypoxia PET images of head and neck cancer patients and compared imaging metrics with human ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Graves EE,Hicks RJ,Binns D,Bressel M,Le QT,Peters L,Young RJ,Rischin D

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Radioligand binding studies show that beta(1)-adrenoceptor (beta(1)-AR) density may be reduced in heart disease without down regulation of beta(2)-ARs. Radioligands are available for measuring total beta-AR density non-invasively with clinical positron emission tomography (PET) but none are selective for beta(1...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Law MP,Wagner S,Kopka K,Pike VW,Schober O,Schäfers M

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Familial adenomatous polyposis (FAP) is characterised by colonic and duodenal adenomatous polyps that carry a risk of malignant transformation. Malignant degeneration of duodenal adenomas is difficult to detect. We speculated that 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) might...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Kouwen MC,Drenth JP,van Krieken JH,van Goor H,Friederich P,Oyen WJ,Nagengast FM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to monitor the metabolic effects of temozolomide (TMZ) chemotherapy in malignant gliomas by means of repeated positron emission tomography (PET) with [(11)C]methionine (MET). METHODS:Fifteen patients with histologically proven malignant glioma were treated by TMZ chemotherapy. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Galldiks N,Kracht LW,Burghaus L,Thomas A,Jacobs AH,Heiss WD,Herholz K

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:Both head and neck magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) play a crucial role in the staging of primary nasopharyngeal carcinoma (NPC). In this study, we sought to prospectively investigate the clinical utility of simulta...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Chan SC,Yeh CH,Yen TC,Ng SH,Chang JT,Lin CY,Yen-Ming T,Fan KH,Huang BS,Hsu CL,Chang KP,Wang HM,Liao CT

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Our study intended to explore the association between combining 18F-FDG PET/CT metabolic parameters and other clinical features and anaplastic lymphoma kinase (ALK) or c-ros oncogene 1 (ROS1) fusion in non-small-cell lung cancer (NSCLC). METHODS:Eight hundred and six patients with wild-type epidermal growth fa...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ruan M,Liu L,Wang L,Lei B,Sun X,Chang C,Shen Y,Xie W

更新日期：2020-05-01 00:00:00

abstract：:The above article which was published in Volume 44/ Issue 12 has incorrect page numbers. Instead of 1-3, it should have been 2137-2139. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Giammarile F,Muylle K,Delgado Bolton R,Kunikowska J,Haberkorn U,Oyen W

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Medial temporal impairment can be detected clinically and by morphological imaging during Alzheimer's disease (AD), but the existence of a functional impairment in this area seems to be less well established. Yet such functional impairment is classically found in other degenerative cortical dementias, such as t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Basely M,Ceccaldi M,Boyer L,Mundler O,Guedj E

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Brain serotonin 6 receptor (5-HT6) is one of the most recently identified serotonin receptors. It is a potent therapeutic target for psychiatric and neurological diseases, e.g. schizophrenia and Alzheimer's disease. Since no specific fluorinated radioligand has yet been successfully used to study this receptor ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Becker G,Colomb J,Sgambato-Faure V,Tremblay L,Billard T,Zimmer L

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:In the era of precision medicine, patient-specific dose calculation using Monte Carlo (MC) simulations is deemed the gold standard technique for risk-benefit analysis of radiation hazards and correlation with patient outcome. Hence, we propose a novel method to perform whole-body personalized organ-level dosime...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Akhavanallaf A,Shiri I,Arabi H,Zaidi H

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate whether( 18)F-fluorodeoxyglucose (FDG) uptake, quantified by positron emission tomography (PET), correlates with histological variables including tumour grade, cell proliferation, cell cycle control integrity and glucose metabolism in patients with bone and soft tissue sa...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tateishi U,Yamaguchi U,Seki K,Terauchi T,Arai Y,Hasegawa T

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:Reduced presynaptic dopaminergic activity plays an important role in the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of LID onset. METHODS:From among 412 drug...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yoo HS,Chung SJ,Chung SJ,Moon H,Oh JS,Kim JS,Hong JY,Ye BS,Sohn YH,Lee PH

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients. MATERIALS AND METHODS:One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January-June 2018...

journal_title：European journal of nuclear medicine and molecular imaging

authors： López-Mora DA,Flotats A,Fuentes-Ocampo F,Camacho V,Fernández A,Ruiz A,Duch J,Sizova M,Domènech A,Estorch M,Carrió I

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:123I-labelled mZIENT (2β-carbomethoxy-3β-(3′-((Z)-2-iodoethenyl)phenyl)nortropane) has been developed as a radioligand for the serotonin transporter. The aim of this preliminary study was to assess its whole-body biodistribution in humans and estimate dosimetry. METHODS:Three healthy controls and three patient...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nicol A,Krishnadas R,Champion S,Tamagnan G,Stehouwer JS,Goodman MM,Hadley DM,Pimlott SL

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the feasibility of assessing dopamine transporter binding after treatment with methylphenidate in the rat using a recently developed high-resolution small animal single-photon emission computed tomograph (TierSPECT) and [123I]FP-CIT. METHODS:[123I]FP-CIT was administere...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nikolaus S,Wirrwar A,Antke C,Arkian S,Schramm N,Müller HW,Larisch R

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:In about 30% of patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgical resection for locally advanced oesophageal cancer no vital tumour is found in the resection specimen. Accurate clinical response assessment is critical if deferral from surgery is considered in complete responders. O...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vollenbrock SE,Voncken FEM,Lambregts DMJ,Maas M,Donswijk ML,Vegt E,Ter Beek LC,van Dieren JM,van Sandick JW,Aleman BMP,Beets-Tan RGH,Bartels-Rutten A

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate and compare, by means of dynamic PET, the pharmacokinetics of 68Ga-DOTATOC, a tracer which reflects the expression of somatostatin receptors (SSTRs), and of [18F]FDG, a marker of tumour viability, in patients with metastatic neuroendocrine tumours (NETs) in whom 90Y-DOT...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Koukouraki S,Strauss LG,Georgoulias V,Eisenhut M,Haberkorn U,Dimitrakopoulou-Strauss A

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:PSMA ligand imaging with hybrid PET/MRI scanners could be an integral part of the clinical routine in the future. However, the first study about this novel method revealed a severe photopenic artifact ("halo artifact") around the urinary bladder causing significantly reduced tumor visibility. The aim of this ev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Afshar-Oromieh A,Wolf M,Haberkorn U,Kachelrieß M,Gnirs R,Kopka K,Schlemmer HP,Freitag MT

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE). METHODS:We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and tempor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dupont P,Zaknun JJ,Maes A,Tepmongkol S,Vasquez S,Bal CS,Van Paesschen W,Carpintiero S,Locharernkul C,Dondi M

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yakushev I,Schreckenberger M,Müller MJ,Schermuly I,Cumming P,Stoeter P,Gerhard A,Fellgiebel A

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Although resynchronisation therapy (CRT) is a promising addition to heart failure therapy, a substantial number of patients do not respond to CRT. As FDG PET has routinely been used for prediction of improvement after revascularisation in ischaemic cardiomyopathy, it was hypothesised that there is also a relati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Campen CM,Visser FC,van der Weerdt AP,Knaapen P,Comans EF,Lammertsma AA,de Cock CC,Visser CA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of (11)C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC). MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Grosu AL,Weirich G,Wendl C,Prokic V,Kirste S,Geinitz H,Souvatzoglou M,Gschwend JE,Schwaiger M,Molls M,Weber WA,Treiber U,Krause BJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:We previously reported in a small series of patients that (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) scintigraphy tested positive in transthyretin-related (TTR) (both mutant and wild-type) but not in primary (AL) amyloidotic cardiomyopathy (AC). We extended our study to a larger cohort o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rapezzi C,Quarta CC,Guidalotti PL,Longhi S,Pettinato C,Leone O,Ferlini A,Salvi F,Gallo P,Gagliardi C,Branzi A

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:Prostate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal human prostate and bladder, is over-expressed in the majority of localized prostate cancer and most bone metastases. We have previously shown that the hu1G8 minibody, a humanized anti-PSCA antibody fragment (single-chain Fv-C(H)3...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lepin EJ,Leyton JV,Zhou Y,Olafsen T,Salazar FB,McCabe KE,Hahm S,Marks JD,Reiter RE,Wu AM

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Imaging the 18-kDa translocator protein (TSPO) is considered a potential tool for in vivo evaluation of microglial activation and neuroinflammation in the early stages of Alzheimer's disease (AD). ((R)-1-(2-chlorophenyl)-N-[(11)C]-methyl-N-(1-methylpropyl)-3-isoquinoline caboxamide ([(11)C]-(R)-PK11195) has bee...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Varrone A,Mattsson P,Forsberg A,Takano A,Nag S,Gulyás B,Borg J,Boellaard R,Al-Tawil N,Eriksdotter M,Zimmermann T,Schultze-Mosgau M,Thiele A,Hoffmann A,Lammertsma AA,Halldin C

更新日期：2013-06-01 00:00:00