Premalignant lesions of the anal margin.

Abstract:

:Premalignant lesions of the anal margin include Bowen's disease (intraepithelial squamous cell carcinoma) and Paget's disease (intraepithelial adenocarcinoma). Our experience includes 11 patients with perianal Paget's disease and 37 patients with perianal Bowen's disease treated from 1957 to 1986. The patients with perianal Paget's disease were older, had a higher incidence of invasive cancer, and had a worse prognosis than those with perianal Bowen's disease. The characteristic appearance of these lesions and their failure to respond to conventional therapy should lead the clinician to obtain a biopsy, which readily establishes the diagnosis. Our experience confirms that adequate evaluation followed by wide local excision is the appropriate therapy. Close follow-up is recommended to identify recurrence of the perianal disease or development of other malignancies.

journal_name

South Med J

journal_title

Southern medical journal

authors

Beck DE,Fazio VW

doi

10.1097/00007611-198904000-00016

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

470-4

issue

4

eissn

0038-4348

issn

1541-8243

journal_volume

82

pub_type

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