Abstract:
:We investigated apoptotic effects and changes in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in liver and gill tissues of fish exposed to chlorpyrifos. Three different chlorpyrifos doses (2.25, 4.5 and 6.75 μg/L) were administrated to rainbow trout at different time intervals (24, 48, 72 and 96 h). Acute exposure to chlorpyrifos showed time dependent decrease in G6PD enzyme activity at all concentrations (p < 0.05). Immunohistochemical results showed that chlorpyrifos caused mucous cell loss in gill tissue and apoptosis via caspase-3 activation in fish. The present study suggested that chlorpyrifos inhibits G6PD enzyme and causes mucous cell loss in gill and apoptosis in gill and liver tissues.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Topal A,Atamanalp M,Oruç E,Kırıcı M,Kocaman EMdoi
10.1016/j.tice.2014.09.001subject
Has Abstractpub_date
2014-12-01 00:00:00pages
490-6issue
6eissn
0040-8166issn
1532-3072pii
S0040-8166(14)00077-9journal_volume
46pub_type
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