Abstract：
BACKGROUND:Few studies have examined the underweight-morbidity relationship, and those that have were conducted in non-U.S. populations and limited in their evaluation of cardiovascular disease (CVD) risk factors. PURPOSE:To examine the associations among underweight (along with overweight and obese) and various CVD risk factors in a national sample of U.S. adults (aged ≥20 years). METHODS:Ten years of data (1999-2010) from the National Health and Nutrition Examination Survey were used (analyzed in 2014). Underweight (tertiles); overweight (25-29.9); and obesity (three classes: 30-34.9, 35-39.9, and ≥40) were assessed from measured BMI. The evaluated biological and anthropometric markers included waist circumference; mean arterial pressure; C-reactive protein (CRP); fasting low-density lipoprotein (LDL) cholesterol; total cholesterol; fasting triglycerides; and fasting glucose. RESULTS:After adjustments, underweight adults had significantly (p<0.005) lower levels of CRP (β=-0.12, Tertile 2); total cholesterol (β=-17.7 and -12.2, Tertiles 1 and 3); total cholesterol to high-density lipoprotein cholesterol ratio (β=-0.39 and -0.46, Tertiles 2 and 3); LDL cholesterol (β=-20.7, Tertile 1); and triglycerides (β=-37.1 and -18.0, Tertiles 1 and 3) compared to normal-weight individuals. The severely underweight and obese were less likely to be physically active than normal-weight adults (p<0.001). Adults in each of the overweight and obese groups had higher levels for each biomarker compared to normal-weight individuals. CONCLUSIONS:Underweight adults have lower (i.e., more favorable) levels of various CVD biomarkers.
journal_name
Am J Prev Medjournal_title
American journal of preventive medicineauthors
Loprinzi PD,Crespo CJ,Andersen RE,Smit Edoi
10.1016/j.amepre.2014.08.019subject
Has Abstractpub_date
2015-03-01 00:00:00pages
338-44issue
3eissn
0749-3797issn
1873-2607pii
S0749-3797(14)00486-3journal_volume
48pub_type
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