Immunophenotypic characterization of human glioblastoma stem cells: correlation with clinical outcome.

abstract：:Our previous study demonstrate that vitamin D3 induces the binding of vitamin D3 receptor (VDR) to Sp1 transcription factor and stimulates p27Kip1 expression via the Sp1 consensus sequences in the promoter. Both VDR and Sp1 are transcriptional activators, it is unclear which protein functions as the transcription comp...

journal_title：Journal of cellular biochemistry

authors： Cheng HT,Chen JY,Huang YC,Chang HC,Hung WC

更新日期：2006-08-15 00:00:00

abstract：:Male pronucleus formation involves sperm nucleus decondensation and sperm chromatin remodeling. In sea urchins, male pronucleus decondensation was shown to be modulated by protein kinase C and a cdc2-like kinase sensitive to olomoucine in vitro assays. It was further demonstrated that olomoucine blocks SpH2B and SpH1 ...

journal_title：Journal of cellular biochemistry

authors： Monardes A,Iribarren C,Morin V,Bustos P,Puchi M,Imschenetzky M

更新日期：2005-10-01 00:00:00

abstract：:Osteotesticular protein tyrosine phosphatase (OST-PTP; OST), is a signaling molecule which catalyzes the removal of phosphates from tyrosine residues. It is known to be highly regulated in bone cells and has been shown to be important for the in vitro progression from a preosteoblast to a mature, mineralizing cell. Ho...

journal_title：Journal of cellular biochemistry

authors： Yunker LA,Undersander A,Lian JB,Stein GS,Carlson CS,Mauro LJ

更新日期：2004-11-01 00:00:00

abstract：:During the past several years, numerous laboratories have reported isolation and purification of proteinase inhibitors from human urine. Many of these molecules were incompletely characterized and some of them may have been artifacts in part because of harsh procedures used for their isolation. Consequently, there is ...

journal_title：Journal of cellular biochemistry

authors： Chawla RK,Lawson DH,Ahmad M,Travis J

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVES:Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients. T...

journal_title：Journal of cellular biochemistry

authors： Shen X,Cui X,Cui H,Jin Y,Jin W,Sun H

更新日期：2019-04-01 00:00:00

abstract：:Four detergents have been compared for identification of the Plasmodium knowlesi variant antigen on infected erythrocytes by immunoprecipitation analysis. Erythrocytes infected with late trophozoite and schizont forms of cloned asexual parasites were labeled by lactoperoxidase-catalyzed radioiodination and extracted e...

journal_title：Journal of cellular biochemistry

authors： Howard RJ,Barnwell JW

更新日期：1984-01-01 00:00:00

abstract：:The NAD-dependent deacetylase Sirtuin 1 (SIRT1) plays a vital role in leukemogenesis. Nicotinamide (NAM) is the principal NAD+ precursor and a noncompetitive inhibitor of SIRT1. In our study, we showed that NAM enhanced the sensitivity of chronic myeloid leukemia (CML) to doxorubicin (DOX) via SIRT1. We found that SIR...

journal_title：Journal of cellular biochemistry

authors： Pan S,Leng J,Deng X,Ruan H,Zhou L,Jamal M,Xiao R,Xiong J,Yin Q,Wu Y,Wang M,Yuan W,Shao L,Zhang Q

更新日期：2020-01-01 00:00:00

abstract：:Platelets are critical regulators of liver regeneration, but the mechanisms are still not fully understood. Platelets have been shown to contain a wide variety of microRNAs (miRNAs) and play an important role in many diseases. However, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate th...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Li W,Liang G,Peng J,Xu X

更新日期：2020-07-21 00:00:00

abstract：:Decreased translation initiation adversely impacts protein synthesis and contributes to the myocardial dysfunction produced by sepsis. Therefore, the purpose of the present study was to identify sepsis-induced changes in signal transduction pathways known to regulate translation initiation in cardiac muscle and to det...

journal_title：Journal of cellular biochemistry

authors： Lang CH,Pruznak AM,Frost RA

更新日期：2005-02-01 00:00:00

abstract：:In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the primary mediator of these effects. The structure-activity relationships of a putative L-leucine r...

journal_title：Journal of cellular biochemistry

authors： Lynch CJ,Fox HL,Vary TC,Jefferson LS,Kimball SR

更新日期：2000-03-01 00:00:00

abstract：:Loss of mechanical stress causes bone loss. However, the mechanisms underlying the unloading-induced bone loss are largely unknown. Here, we examined the effects of gold-thioglucose (GTG) treatment, which destroys ventromedial hypothalamus (VMH), on unloading-induced bone loss. Unloading reduced bone volume in control...

journal_title：Journal of cellular biochemistry

authors： Hino K,Nifuji A,Morinobu M,Tsuji K,Ezura Y,Nakashima K,Yamamoto H,Noda M

更新日期：2006-10-15 00:00:00

abstract：:Understanding how the information is conveyed from outside to inside the cell is a critical challenge for all biologists involved in signal transduction. The flow of information initiated by cell-cell and cell-extracellular matrix contacts is mediated by the formation of adhesion complexes involving multiple proteins....

journal_title：Journal of cellular biochemistry

authors： Lelièvre SA,Bissell MJ

更新日期：1998-01-01 00:00:00

abstract：:Previous work has suggested that changes in nuclear membrane cholesterol may induce a stimulation in nuclear nucleoside triphosphatase (NTPase) activity. The purpose of the present study was to directly investigate if nuclear membrane cholesterol can stimulate nuclear NTPase activity. The cholesterol content of nuclei...

journal_title：Journal of cellular biochemistry

authors： Ramjiawan B,Czubryt MP,Gilchrist JS,Pierce GN

更新日期：1996-12-15 00:00:00

abstract：:In mice, the first round of DNA replication occurs in fertilized eggs (1-cell embryos), while the onset of zygotic gene transcription begins approximately 20 hours after fertilization, a time that normally coincides with formation of a 2-cell embryo. One approach to investigating the mechanisms that control these deve...

journal_title：Journal of cellular biochemistry

authors： Majumder S,DePamphilis ML

更新日期：1994-05-01 00:00:00

abstract：:CD19+ CD24hi CD38hi cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19+ CD24hi CD38hi cells. Changes in B-cell subpopulations and CD19+ CD24hi CD38hi cells have been observed in systemic lupus erythematosus (SLE) patients. Whether...

journal_title：Journal of cellular biochemistry

authors： Wang H,Liu C,Chen W,Ding G

更新日期：2019-02-16 00:00:00

abstract：:Long-term treatment with heparin has been associated with an increased risk of osteoporosis. Given the importance of heparan sulfate proteoglycans for bone metabolism, it can be anticipated that heparin due to its structural similarity with heparan sulfate chains somehow interferes with the biological activities of th...

journal_title：Journal of cellular biochemistry

authors： Hausser HJ,Brenner RE

更新日期：2004-04-01 00:00:00

abstract：:Nucleic acids and regulatory proteins are architecturally organized in nuclear microenvironments. The compartmentalization of regulatory machinery for gene expression, replication and repair, is obligatory for fidelity of biological control. Perturbations in the organization, assembly and integration of regulatory mac...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Davie JR,Knowlton JR,Zaidi SK

更新日期：2008-08-15 00:00:00

abstract：:Our previous studies have shown that vanadium, a dietary micronutrient, has an inhibitory effect against experimentally induced rat hepatocarcinogenesis. In this study, we evaluated the role of vanadium on some potential protein expression markers of carcinogenesis, such as metallothionein (MT), an intracellular metal...

journal_title：Journal of cellular biochemistry

authors： Chakraborty T,Samanta S,Ghosh B,Thirumoorthy N,Chatterjee M

更新日期：2005-03-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

journal_title：Journal of cellular biochemistry

authors： Sun NK,Huang SL,Chang TC,Chao CC

更新日期：2013-08-01 00:00:00

abstract：:Breast cancer, the most common cancer in women worldwide, is associated with high mortality. The long non-coding RNAs (lncRNAs) with a little capacity of coding proteins is playing an increasingly important role in the cancer paradigm. Accumulating evidences demonstrate that lncRNAs have crucial connections with breas...

journal_title：Journal of cellular biochemistry

authors： He Y,Li X,Meng Y,Fu S,Cui Y,Shi Y,Du H

更新日期：2019-10-01 00:00:00

abstract：:Elevation of free fatty acids (FFAs) is known to affect microvascular function and contribute to obesity-associated insulin resistance, hypertension, and microangiopathy. Proliferative and synthetic vascular smooth muscle cells (VSMCs) increase intimal thickness and destabilize atheromatous plaques. This study aimed t...

journal_title：Journal of cellular biochemistry

authors： Cheng CI,Lee YH,Chen PH,Lin YC,Chou MH,Kao YH

更新日期：2017-05-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) stimulates the expression of a number of genes associated with entry of quiescent Balb/c-3T3 fibroblasts into the cell cycle. We determined that two of these genes, c-myc and c-fos, are induced equivalently in medium supplemented with platelet-poor plasma (PPP) and either PDGF-BB ...

journal_title：Journal of cellular biochemistry

authors： Coats SR,Olson JE,Pledger WJ

更新日期：1992-03-01 00:00:00

abstract：:In vitro assembly of functional liver tissue is a prerequisite for the transplantation of tissue-engineered livers. There is an increasing demand for in vitro models that replicate complex events occurring in the liver. However, tissue engineering of implantable liver systems is currently limited by the difficulty of ...

journal_title：Journal of cellular biochemistry

authors： Alzebdeh DA,Matthew HW

更新日期：2017-09-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) transcription factors have been shown to play an important role in controlling cell type determination and differentiation. TWIST, a member of the bHLH transcription factor family, is involved in the development of mesodermally derived tissue, including the skeleton. We examined the role ...

journal_title：Journal of cellular biochemistry

authors： Lee MS,Lowe GN,Strong DD,Wergedal JE,Glackin CA

更新日期：1999-12-15 00:00:00

abstract：:Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

journal_title：Journal of cellular biochemistry

authors： Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

更新日期：2018-12-01 00:00:00

abstract：:We investigated the association of DNA polymerase and DNA primase activity with the nuclear matrix in HeLa S3 cells diluted with fresh medium after having been cultured without any medium change for 7 days. Flow cytometric analysis demonstrated that just before dilution about 85% of the cells were in the G1 phase of t...

journal_title：Journal of cellular biochemistry

authors： Martelli AM,Capitani S,Neri LM

更新日期：1998-10-01 00:00:00

abstract：:Generation of osteoblasts from human somatic cells may be applicable in an effective transplantation therapy against bone diseases. Recently we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some transcription factor genes via retroviral vectors. However, retroviral vecto...

journal_title：Journal of cellular biochemistry

authors： Yamamoto K,Sato Y,Honjo K,Ichioka H,Oseko F,Sowa Y,Yamamoto T,Kanamura N,Kishida T,Mazda O

更新日期：2016-11-01 00:00:00

abstract：:Cancer is characterized by uncontrolled cell division resulting from multiple mutagenic events. Cancer chemoprevention strategies aim to inhibit or reverse these events using natural or synthetic pharmacologic agents. Ideally, this restores normal growth control mechanisms. Diverse classes of compounds have been ident...

journal_title：Journal of cellular biochemistry

authors： Freemantle SJ,Liu X,Feng Q,Galimberti F,Blumen S,Sekula D,Kitareewan S,Dragnev KH,Dmitrovsky E

更新日期：2007-11-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) pathway is dysregulated in more than 50% of all human malignancies and is a major target in cancer treatment. In this study, we explored the underlying mechanism involving microRNA-145-3p (miR-145-3p) in the development and progression of non-small cell lung cancer (NSCLC) by t...

journal_title：Journal of cellular biochemistry

authors： Chen GM,Zheng AJ,Cai J,Han P,Ji HB,Wang LL

更新日期：2018-01-01 00:00:00

abstract：:The following thiol-containing peptide analogues of the carboxyl side of the collagenase-sensitive bond of collagen were synthesized and tested as inhibitors of collagenases partially purified from homogenates of rabbit V-2 tumor and culture medium of pig synovium: HSCH2CH(CH3)CO-Ala-OEt (I), HSCH2CH(CH2Ph)CO-Ala-OEt ...

journal_title：Journal of cellular biochemistry

authors： Gray RD,Miller RB,Spatola AF

更新日期：1986-01-01 00:00:00