Abstract:
STUDY DESIGN:Psychometric study using retrospectively collected data. OBJECTIVES:We investigated the comparability of quantitative computed tomography (qCT) in assessing bone mineral density (BMD) with dual energy X-ray absorptiometry (DXA). We evaluated how well previously suggested normal values for spinal Hounsfield units (HU) correlated with routine DXA results in patients with chronic spinal cord injury (SCI). Furthermore, we investigated inter/intra-observer reliability of measuring HU in the spine. SETTING:Academic medical center in Tehran, Iran. METHODS:Spinal CT scans of 44 male participants with chronic SCI who had undergone DXA studies on the same day were selected. The main outcome measures were sensitivity, specificity, and area under curve (AUC) of HU at each spinal region against DXA results of areal BMD. The secondary outcome was inter/intra-observer reliability of measuring HU in the spinal column. RESULTS:We found no significant difference between qCT and DXA results (p-value = 0.237, R = 0.188). However, the two methods showed overall unfavorable comparability, with a sensitivity of 0%, 0%, and 80%, specificity of 50%, 90%, and 85%, and area under curve (AUC) of 0.27, 0.53, and 0.83 for cervical, thoracic, and lumbar spine, respectively. The best comparability was achieved at the lumbar region although not statistically significant (p-value = 0.072). Measuring HU was reliable (inter/intra-observer reliability >98%). CONCLUSIONS:This study demonstrates that currently proposed normal values result in unfavorable comparability in the cervical and thoracic regions; however, as the agreement improved at the lumbar spine, it is possible that qCT could become an indicator of bone strength with further research.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Haghighat Khah HR,Moradi N,Taheri T,Sanei Taheri M,Rayegani SMdoi
10.1038/s41393-017-0041-3subject
Has Abstractpub_date
2018-05-01 00:00:00pages
487-493issue
5eissn
1362-4393issn
1476-5624pii
10.1038/s41393-017-0041-3journal_volume
56pub_type
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