Abstract:
OBJECTIVES:Hereditary spastic paraplegia (HSP) is a degenerative central nervous system disorder characterized by progressive spasticity and hyperreflexia of the lower limbs. Often, patients with HSP experience symptoms of voiding dysfunction. Urodynamic evaluations of these patients are rarely reported in the literature and the etiology of voiding dysfunction remains unclear. The present study characterizes lower urinary tract dysfunction in a large series of patients. METHODS:The medical records of 29 HSP patients who underwent urodynamic evaluation were retrospectively analyzed. The history of lower urinary tract symptoms was noted and the urodynamic findings analyzed. RESULTS:Urgency was the most dominant complaint (72.4%), followed by frequency (65.5%), urinary incontinence (55.2%) and hesitancy (51.7%). The urodynamic findings showed signs of central neurogenic bladder in 24 patients (82.7%), with detrusor overactivity (DO) in 15 patients (51.7%) and detrusor sphincter dyssynergia (DSD) in 19 (65.5%). Post-void residual (PVR) of >10% of the voided volume was found in 12 patients (41.4%). There were significant relationships between detrusor overactivity and PVR (P=0.005), frequency (P=0.046) and nocturia (P=0.045). Ultrasound examination revealed no upper urinary tract complications. CONCLUSION:Despite the presence of DO and DSD, HSP patients do not seem to have a high risk of developing ultrasonographically-assessed upper urinary tract complications after a mean follow-up of 22 years, contrary to spinal cord injury population. These results may guide practitioners in their decision-making about the appropriate evaluation and treatment of bladder disturbances that accompany hereditary spastic paraplegia.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Fourtassi M,Jacquin-Courtois S,Scheiber-Nogueira MC,Hajjioui A,Luaute J,Charvier K,Maucort-Boulch D,Rode Gdoi
10.1038/sc.2011.193subject
Has Abstractpub_date
2012-07-01 00:00:00pages
558-62issue
7eissn
1362-4393issn
1476-5624pii
sc2011193journal_volume
50pub_type
杂志文章相关文献
SPINAL CORD文献大全abstract:STUDY DESIGN:Randomised double-blind factorial-design placebo-controlled trial. OBJECTIVE:Urinary tract infections (UTIs) are common in people with spinal cord injury (SCI). UTIs are increasingly difficult to treat due to emergence of multi-resistant organisms. Probiotics are efficacious in preventing UTIs in post-men...
journal_title:Spinal cord
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41393-019-0251-y
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to investigate the changes of urothelial junction proteins, apoptosis and suburothelial inflammation after detrusor injection of botulinum toxin A (BoNT-A) in patients with spinal cord injury (SCI) and neurogenic detrusor overactivity (NDO). METHODS:A total of 26 patients with ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2015.241
更新日期:2016-10-01 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:To report a rare case of intramedullary thoracic tuberculoma. SETTING:China Rehabilitation Research Center, Beijing, China. CASE REPORT:A 42-year-old Chinese man presented with the complaints of weakness of the lower extremities and urinary retention. Neurological examinations con...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2009.58
更新日期:2010-01-01 00:00:00
abstract:STUDY DESIGN:A combination of review of case notes and outpatient follow-up. OBJECTIVE:To evaluate the effectiveness of the modified Girdlestones-Taylor procedure in patients with spinal cord injury (SCI). SETTING:Princess Royal Spinal Injuries Centre (PRSIC), Northern General Hospital, Sheffield, UK. METHODS:Nine p...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101924
更新日期:2006-12-01 00:00:00
abstract:STUDY DESIGN:A case report. SETTING:Department of Orthopaedic Surgery, Shiga University of Medical Science, Japan. PATIENT:A 13-year-old woman presented progressive weakness in the lower extremities, with predominance on the right. Magnetic resonance (MR) imaging revealed a huge syrinx. The patient also showed scolio...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101607
更新日期:2004-09-01 00:00:00
abstract:STUDY DESIGN:Inception cohort. OBJECTIVES:The clinical impression that earwax is uncommonly frequent among spinal cord injury patients with high levels of paralysis was tested. SETTING:Veterans Administration Hospital, USA. METHODS:A cohort of 15 chronically paralyzed patients, motor complete, living as residents in...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101444
更新日期:2003-04-01 00:00:00
abstract:STUDY DESIGN:Epidemiological follow-up study. OBJECTIVE:To examine the bladder-emptying methods at least 10 years after a traumatic spinal cord injury (SCI). SETTING:Clinic for Para- and Tetraplegia and Department of Urology, Rigshospitalet, Copenhagen University Hospital, Denmark. METHODS:Retrospective data collect...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101637
更新日期:2004-11-01 00:00:00
abstract:STUDY DESIGN:Prospective, randomized, placebo-controlled, experimental study. OBJECTIVES:The issue of whether nitric oxide (NO) production is beneficial or deleterious on ischemic injuries of the central nervous system still remains doubtful. Vascular endothelial growth factor (VEGF) is known to induce the release of ...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3102066
更新日期:2008-02-01 00:00:00
abstract:STUDY DESIGN:Case-control study. OBJECTIVES:The objective of this study was to provide some useful information concerning the incidence, clinical features, and risk factors for symptomatic postoperative spinal epidural hematoma (SPSEH) in an isolated cohort of patients undergoing spine tumor surgery. SETTING:Hospital...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/s41393-019-0281-5
更新日期:2019-08-01 00:00:00
abstract:STUDY DESIGN:The study has been designed as a case report. OBJECTIVE:The objective of this study was to report a rare case of syringomyelia in a patient with syphilitic spinal meningitis. SETTING:The Neurology Department, University Hospital Mohamed VI Marrakesh, Morocco. CASE REPORT:A 40-year-old Moroccan male pres...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2010.184
更新日期:2011-06-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional clinical study. OBJECTIVES:Plastic changes within cortical areas occur after traumatic spinal cord injury (TSCI). The aim of the study was to assess cortical activation in the chronic phase of TSCI using functional magnetic resonance imaging (fMRI). SETTING:Tartu University Hospital, Tart...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2015.158
更新日期:2016-01-01 00:00:00
abstract:STUDY DESIGN:One cross-sectional study. OBJECTIVES:To examine the extent to which a sample of adults with spinal cord injury (SCI) meet the SCI-specific physical activity guidelines and to identify potential demographic, injury and motivational characteristics related to participation. SETTING:Quebec, Canada. METHOD...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2016.181
更新日期:2017-05-01 00:00:00
abstract:STUDY DESIGN:Retrospective case-control study. OBJECTIVES:The intent of this study was to investigate the relationships between vertebral degenerative changes resulting in spinal canal stenosis, spinal cord lesions and the development of spinal cord decompression sickness (DCS) in scuba divers. SETTING:Referral hyper...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2013.121
更新日期:2014-03-01 00:00:00
abstract:STUDY DESIGN:This is a cross-sectional study. OBJECTIVES:The goal of this study was to characterize the diffusion properties across segments of the spinal cord and peak cerebrospinal fluid (CSF) velocities in the stenotic spinal canal, and to determine the correlation between these properties and clinical and electrop...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2015.57
更新日期:2015-08-01 00:00:00
abstract:STUDY DESIGN:In vitro studies using isolated guinea pig spinal cord white matter. OBJECTIVES:To determine whether lack of oxygen can cause irreversible impairment of electrical impulse conduction. SETTING:Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana, USA. METHODS:The hypoxic injur...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101901
更新日期:2006-11-01 00:00:00
abstract:STUDY DESIGN:A retrospective study. OBJECTIVES:To investigate the risk factors of vesicoureteral reflux in the early stage of spinal cord injury. SETTING:Japan. METHODS:Urological evaluation, including cystography and urodynamic study was performed in patients in the early stage of spinal cord injury. The patients w...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101091
更新日期:2001-01-01 00:00:00
abstract:STUDY DESIGN:An observational study. OBJECTIVE:We report clinical, MRI and urodynamic findings in spinal tuberculosis. SETTING:Tertiary care teaching hospital. METHOD:Patients with spinal tuberculosis having micturition disturbances or high postvoidal residual (PVR) urine were subjected to clinical evaluation, urody...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2009.199
更新日期:2010-09-01 00:00:00
abstract:STUDY DESIGN:A biomechanical unitary classification of spinal injuries is proposed. OBJECTIVE:To present an evaluation of spinal injuries based on the essential traumatic spinal mechanisms: axial deformation, torsion, translation and combined mechanisms in connection with the concept of the stabilizing axial spinal pi...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101468
更新日期:2003-07-01 00:00:00
abstract::The purpose of the study was to use dual energy X-ray absorptiometry to measure bone mineral density (BMD) in the lumbar spine, the femoral neck, Ward's triangle, and the greater trochanter in 204 men (69 able-bodies controls and 135 spinal cord injured patients) stratified according to age (20-39, 40-59, and 60+ year...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3100394
更新日期:1997-06-01 00:00:00
abstract:STUDY DESIGN:A randomized, prospective, double-blind, placebo-controlled clinical trial. OBJECTIVES:To determine the effect of COX-2-selective inhibitor on the prevention of heterotopic ossification (HO) after spinal cord injury (SCI). SETTING:County and University Teaching Hospital, Miami, FL, USA. METHODS:A total ...
journal_title:Spinal cord
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.sc.3101628
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To create the International Spinal Cord Injury (SCI) Female Sexual and Reproductive Function Basic Data Set within the International SCI Data Sets. SETTING:An international working group. METHODS:The draft of the data set was developed by an international working group consisting of members appointed by the...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2011.7
更新日期:2011-07-01 00:00:00
abstract:STUDY DESIGN:An in vivo study using a spinal cord compression model in rats. OBJECTIVES:To evaluate the effect of adenosine on thermal hyperalgesia after spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA:After SCI, some patients suffer dysesthesia that is unresponsive to conventional treatments. We previously esta...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2009.194
更新日期:2010-09-01 00:00:00
abstract:STUDY DESIGN:Prospective randomized single blind study. OBJECTIVES:To find out the incidence of deep vein thrombosis (DVT) in Indian acute spinal cord injury (ASCI) subjects with and without pharmacological prophylaxis. SETTING:Indian Spinal Injuries Centre. METHODS:Seventy four ASCI subjects were randomly divided i...
journal_title:Spinal cord
pub_type: 杂志文章,随机对照试验
doi:10.1038/sc.2014.71
更新日期:2014-07-01 00:00:00
abstract:STUDY DESIGN:Prospective experimental. OBJECTIVES:To compare the cardiorespiratory responses with electrical stimulation (ES) producing either dynamic leg cycling or intermittent isometric leg contractions using the same ES protocol. SETTING:Sydney, Australia. METHODS:Eight paraplegics (T4-T11) performed ES exercise...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2014.85
更新日期:2014-08-01 00:00:00
abstract:DESIGN:Single cases. OBJECTIVE:To compare the effects of manually assisted locomotor training in paraplegic patients with the automated training by a driven gait orthosis. SETTING:ParaCare, University Hospital Balgrist in Zurich, Switzerland. METHODS:Treadmill training with manual assistance and by a driven gait ort...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101154
更新日期:2001-05-01 00:00:00
abstract:STUDY DESIGN:Determination of fat oxidation at three different intensities in trained wheelchair athletes on the treadmill. OBJECTIVE:The aim of the study was to assess the level and highest rate of fat oxidation in endurance-trained wheelchair athletes for recommendation on endurance training. SETTING:Institute of S...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101548
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To provide an overview of our current understanding of the problem of neuropathic pain following spinal cord injury (SCI) and to suggest possible therapeutic options in the near future. METHODS:Original research articles, reviews and book chapters on the subject of pain and SCI. RESULTS:Neuropathic pain fol...
journal_title:Spinal cord
pub_type: 杂志文章,评审
doi:10.1038/sc.2008.136
更新日期:2009-05-01 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVES:To present an interesting case of a 14-year-old male with acute paresis of upper extremities and progressive difficulty with lower extremities. The patient is a competitive wrestler and was performing his daily abdominal workout 'sit-ups' with hands interlocked behind his head. Dur...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sj.sc.3101806
更新日期:2006-03-01 00:00:00
abstract:STUDY DESIGN:Retrospective chart audit. OBJECTIVES:This study investigated changes in sagittal alignment in adults after excision of thoracic spinal cord tumors without spinal fixation. SETTING:Single-center study at an academic orthopedic department in Japan. METHODS:We retrospectively reviewed records for 32 adult...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/s41393-018-0235-3
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:To describe health-related quality of life (HRQoL) in persons with traumatic spinal cord injury (TSCI) and to assess factors that affect HRQoL. STUDY DESIGN:Cross-sectional. METHODS:Eighty Estonian-speaking TSCI patients from the Estonian TSCI database were included in the study. The RAND-36 questionnaire,...
journal_title:Spinal cord
pub_type: 杂志文章
doi:10.1038/sc.2014.47
更新日期:2014-07-01 00:00:00