Abstract：
STUDY DESIGN:A randomized, prospective, double-blind, placebo-controlled clinical trial. OBJECTIVES:To determine the effect of COX-2-selective inhibitor on the prevention of heterotopic ossification (HO) after spinal cord injury (SCI). SETTING:County and University Teaching Hospital, Miami, FL, USA. METHODS:A total of 76 patients were enrolled in the study. Among them, 39 patients received placebo, and 37 received COX-2-selective inhibitor rofecoxib 25 mg daily for a period of 4 weeks. Prevention was started 3 weeks after spinal cord injury (SCI). In both groups of patients there was similar age as well as the level of SCI and ASIA impairment scale. Two methods were used to diagnose early HO, clinical symptoms and bone scintigraphy. Radiography was used for diagnosis of late stages of HO development. RESULTS:A significantly lower incidence of HO was found in the rofecoxib group (13.4%) than in the placebo group (33.3%: P<0.05). In patients receiving rofecoxib, there was a 2.5 times lower relative risk of developing HO than in the placebo group (95% CI, 2.3-6). There were no patients who discontinued the study due to adverse effects of medication. CONCLUSION:Our data suggest that COX-2-selective inhibitor rofecoxib is an effective medication in prevention of HO after SCI.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Banovac K,Williams JM,Patrick LD,Levi Adoi
10.1038/sj.sc.3101628subject
Has Abstractpub_date
2004-12-01 00:00:00pages
707-10issue
12eissn
1362-4393issn
1476-5624pii
3101628journal_volume
42pub_type
临床试验,杂志文章,随机对照试验相关文献
SPINAL CORD文献大全abstract：STUDY DESIGN:This cross-sectional chart review study included 100 US Veterans with spinal cord injuries/disorders (SCI/D) who received care at a Veterans Affairs (VA) SCI facility during a 12-month period. Progress notes were examined to extract need for weight management (WM), patient-provider discussions about risk d...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.59
更新日期：2016-12-01 00:00:00
abstract：STUDY DESIGN:Two patients with diagnosis of unilateral cervical facet fracture due to motor vehicle accident (MVA) are presented, and the literature is reviewed. OBJECTIVE:To discuss the diagnostic difficulties and management strategies in two patients with post-traumatic cervical facet fracture. SETTING:Department o...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101623
更新日期：2004-08-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional study OBJECTIVES: To determine clinical factors associated with telomere length in persons with chronic spinal cord injury (SCI). SETTING:Veterans Affairs Medical Center, Boston, MA. METHODS:Two hundred seventy-eight participants with chronic SCI provided blood samples for measurement of ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0336-7
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to develop the International Spinal Cord Injury (SCI) Endocrine and Metabolic Extended Data Set (ISCIEMEDS) within the framework of the International SCI Data Sets that would facilitate consistent collection and reporting of endocrine and metabolic findings in the SCI populatio...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.164
更新日期：2017-05-01 00:00:00
abstract：:The aim of this study was to quantify the energy cost and the cardiorespiratory response while walking at free speed with an Advanced Reciprocating Gait Orthosis (ARGO). The study was conducted on a group of six male paraplegic patients, age range 16-31 years (median = 22.50), with complete traumatic injuries ranging ...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100564
更新日期：1998-04-01 00:00:00
abstract：STUDY DESIGN:Register study. OBJECTIVES:To design and implement a validation process to check the completeness of the Hospital Discharge Register (HDR) held by the Swedish National Board of Health and Welfare. SETTING:Sweden. METHODS:An accurate traumatic spinal cord injury prevalence group (n=495) was acquired from...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2008.42
更新日期：2008-11-01 00:00:00
abstract：STUDY DESIGN:Epidemiological follow-up study. OBJECTIVE:To examine the bladder-emptying methods at least 10 years after a traumatic spinal cord injury (SCI). SETTING:Clinic for Para- and Tetraplegia and Department of Urology, Rigshospitalet, Copenhagen University Hospital, Denmark. METHODS:Retrospective data collect...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101637
更新日期：2004-11-01 00:00:00
abstract：STUDY DESIGN:Retrospective chart audit. OBJECTIVES:This study investigated changes in sagittal alignment in adults after excision of thoracic spinal cord tumors without spinal fixation. SETTING:Single-center study at an academic orthopedic department in Japan. METHODS:We retrospectively reviewed records for 32 adult...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0235-3
更新日期：2019-05-01 00:00:00
abstract：STUDY DESIGN:Prospective randomized single blind study. OBJECTIVES:To find out the incidence of deep vein thrombosis (DVT) in Indian acute spinal cord injury (ASCI) subjects with and without pharmacological prophylaxis. SETTING:Indian Spinal Injuries Centre. METHODS:Seventy four ASCI subjects were randomly divided i...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sc.2014.71
更新日期：2014-07-01 00:00:00
abstract：STUDY DESIGN:A case report. SETTING:Department of Orthopaedic Surgery, Shiga University of Medical Science, Japan. PATIENT:A 13-year-old woman presented progressive weakness in the lower extremities, with predominance on the right. Magnetic resonance (MR) imaging revealed a huge syrinx. The patient also showed scolio...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101607
更新日期：2004-09-01 00:00:00
abstract：STUDY DESIGN:The study has been designed as a case report. OBJECTIVE:The objective of this study was to report a rare case of syringomyelia in a patient with syphilitic spinal meningitis. SETTING:The Neurology Department, University Hospital Mohamed VI Marrakesh, Morocco. CASE REPORT:A 40-year-old Moroccan male pres...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2010.184
更新日期：2011-06-01 00:00:00
abstract：STUDY DESIGN:Observational study. SETTING:Centre for the Rehabilitation of the Paralysed (CRP), Dhaka, Bangladesh. METHODS:This observational study was conducted on 84 patients of Cervical spinal cord injury (CSCI) due to fall while carrying heavy load on head. They were admitted at the CRP, Dhaka, Bangladesh between...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.153
更新日期：2012-04-01 00:00:00
abstract：STUDY DESIGN:Our aim was to locate research and communicate the evidence found from scientific studies pertaining to the treatment of neurogenic detrusor overactivity (NDO) in the chronic stage of spinal cord injury (SCI). OBJECTIVE:To address the controversy over the traditional (antimuscarinics) and the 'new' treatm...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sc.2011.110
更新日期：2012-01-01 00:00:00
abstract：STUDY DESIGN:Retrospective review of patient medical records comparing the outcomes of two groups of individuals with high-level (C3-4) tetraplegia- those with high-volume and those with low-volume mechanical ventilation. OBJECTIVES:To determine if higher volume mechanical ventilation contributes to faster weaning fro...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100818
更新日期：1999-04-01 00:00:00
abstract：STUDY DESIGN:Single-blind randomized controlled trial of 6 months' duration. OBJECTIVES:To evaluate the efficacy of a novel telehealth intervention, 'CareCall', on reducing pressure ulcers and depression and enhancing the use of appropriate health care. SETTING:General community, Massachusetts and Connecticut, United...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sc.2013.45
更新日期：2013-09-01 00:00:00
abstract：:We describe the development of a registry of veterans with spinal cord dysfunction who have been treated within the Department of Veterans Affairs health care facilities. The registry departs from the function and structure of traditional registries by a more extensive utilization of advances in computer technology; i...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100527
更新日期：1998-01-01 00:00:00
abstract：STUDY DESIGN:A case-control evaluating seminal citrate in patients with spinal cord injury (SCI). OBJECTIVE:Several studies have shown neurological prostatic dysfunction in patients with SCI, as confirmed by low levels of seminal prostate-specific antigen (PSA), which is used as a parameter of gland activity. However,...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2009.62
更新日期：2009-12-01 00:00:00
abstract：STUDY DESIGN:The use of stem cells for functional recovery after spinal cord injury. OBJECTIVE:The aim of this study was to evaluate the effects of a combination of autologous undifferentiated and neural-induced bone marrow mesenchymal stem cells (MSCs) on behavioral improvement in rats after inducing spinal cord inju...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2009.153
更新日期：2010-06-01 00:00:00
abstract：:Different conservative treatment modalities for the lower urinary tract dysfunction in patients with spinal cord lesion are reviewed. Conservative treatment is still the mainstay of the urological management in these patients. Growing experience has changed the classical approach. Spontaneous voiding with and without ...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101160
更新日期：2001-06-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Spinal cord
pub_type： 已发布勘误
doi：10.1038/s41393-020-00534-z
更新日期：2020-10-01 00:00:00
abstract：STUDY DESIGN:A systematic review of all sexual health outcome measures reporting psychometric properties for a spinal cord injury (SCI) population. OBJECTIVES:To evaluate the psychometric evidence for sexual health outcome measures used in a SCI population in order to (1) determine the clinical relevance of current to...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3102136
更新日期：2008-05-01 00:00:00
abstract：STUDY DESIGN:Retrospective chart audit. OBJECTIVES:Firstly determining the prevalence of scoliosis in myelomeningocele (MMC) patients of the University Hospitals Leuven. Secondly analyzing whether there are differences concerning distribution of radiological level, ambulatory status, hydrocephalus, tethered cord, and ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-00611-3
更新日期：2021-01-25 00:00:00
abstract：OBJECTIVES:To investigate the morphological aspects of blood microvasculature of the skin and subcutaneous tissues in subjects with paraplegia with heterotopic ossification (HO). METHODS:In two patients with traumatic spinal cord injury and HO, punch biopsies of skin and hypodermic soft tissue in the region of HO near...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101134
更新日期：2001-11-01 00:00:00
abstract：STUDY DESIGN:Open label study to determine drug dose for a randomized double-blind placebo-controlled parallel study. OBJECTIVES:To assess the efficacy and side effects of oral Delta(9)-tetrahydrocannabinol (THC) and rectal THC-hemisuccinate (THC-HS) in SCI patients. SETTING:REHAB Basel, Switzerland. METHOD:Twenty-f...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.sc.3101982
更新日期：2007-08-01 00:00:00
abstract：STUDY DESIGN:Although abnormal cutaneous reflex (CR) activity has been identified during gait after incomplete spinal cord injury (SCI), this activity has not been directly compared in subjects with and without the spasticity syndrome. OBJECTIVES:Characterisation of CR activity during controlled rest and 'ramp and hol...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.9
更新日期：2016-09-01 00:00:00
abstract：STUDY DESIGN:Register study enhanced and verified by medical records and personal interviews and examinations. SETTINGS:Sweden. OBJECTIVES:To define a method of identifying a study population of rare events. To point out the relative importance of every step, an example is given of identifying persons who sustained t...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101456
更新日期：2003-06-01 00:00:00
abstract：STUDY DESIGN:Experimental study. OBJECTIVE:Individuals with spinal cord injuries (SCI) may present with impaired sympathetic control over thermoregulatory responses to environmental and exercise stressors, which can impact regional core temperature (Tcore) measurement. The purpose of this study was to investigate whet...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0257-5
更新日期：2019-07-01 00:00:00
abstract：STUDY DESIGN:Assessment of spasticity before and after hippotherapy treatment. OBJECTIVE:To evaluate the short-term effect of hippotherapy on spasticity of spinal cord injured patients (SCIs). SETTING:Swiss Paraplegic Centre, Nottwil. METHODS:32 patients with spinal cord injury with various degrees of spasticity had...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101492
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To draw attention to inadequate care received by some spinal cord injury patients after discharge from the regional spinal injury center. SETTING:Regional Spinal Injuries Centre, Southport, UK. METHODS:Presence of the urethral stricture was not recognised in a 69-year-old male with T-3 paraplegia, who atten...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101576
更新日期：2004-08-01 00:00:00
abstract：STUDY DESIGN:Psychometrics study. OBJECTIVES:The aim of this study is to investigate the validity, reliability and sensitivity to change of neurogenic bowel dysfunction (NBD) score. SETTING:Dokuz Eylül University Faculty of Medicine, Turkey. METHODS:The study included 42 patients with spinal cord injury (SCI). The r...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.82
更新日期：2017-12-01 00:00:00
