Abstract：
STUDY DESIGN:An in vivo study using a spinal cord compression model in rats. OBJECTIVES:To evaluate the effect of adenosine on thermal hyperalgesia after spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA:After SCI, some patients suffer dysesthesia that is unresponsive to conventional treatments. We previously established a rat thoracic spinal cord mild-compression model by which we were able to induce thermal hyperalgesia in the hind limbs. METHODS:The thoracic spinal cord was compressed gently using a 20-g weight for 20 min. The withdrawal latency in response to thermal stimulation was monitored bilaterally in the hind limbs using Hargreaves' Plantar test apparatus. RESULTS:SCI-induced thermal hyperalgesia was mimicked by the intrathecal application of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist. Hyperalgesia induced by SCI was significantly inhibited by the intrathecal application of 10-30 nmol chloro-adenosine (Cl-adenosine), a nonselective adenosine receptor agonist. The effect of Cl-adenosine (10 nmol) on hyperalgesia after SCI was blocked by the simultaneous application of DPCPX. Intrathecal application of R(-)N6-(2phenylisopropyl) adenosine (R-PIA; 10 nmol), a selective A1 receptor agonist, also inhibited SCI-induced hyperalgesia. In contrast, intrathecal application of CGS21680, a selective adenosine A2a receptor agonist, did not inhibit SCI-induced hyperalgesia. CONCLUSIONS:These results suggest that adenosine inhibits hyperalgesia through the stimulation of A1 receptors. Adenosine or adenosine A1 receptor agonists should be considered as candidates for new therapeutic methods for treating post-SCI dysesthesia.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Horiuchi H,Ogata T,Morino T,Yamamoto Hdoi
10.1038/sc.2009.194subject
Has Abstractpub_date
2010-09-01 00:00:00pages
685-90issue
9eissn
1362-4393issn
1476-5624pii
sc2009194journal_volume
48pub_type
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