Abstract：
STUDY DESIGN:A pilot study measuring the levels of serum-soluble CD95 ligand (CD95L) in eight spinal cord-injured patients. OBJECTIVES:To determine the soluble concentration of CD95L in spinal cord injury (SCI) patients after trauma. METHODS:We collected blood samples from eight patients with acute traumatic SCI. Soluble CD95L serum levels were determined using an enzyme-linked immunosorbent assay. American Spinal Injury Association (ASIA) was determined according to ASIA classification. The patients were monitored, and venous blood was drawn after arrival at the hospital on the 1st and 3rd day and during the 1st, 2nd, 4th, 8th and 12th weeks after trauma. RESULTS:The average patient age was 48.1 years (18-86 years). Three patients were paraplegic (two incomplete, one complete), five were quadriplegic (one complete, four incomplete). The serum concentration of soluble CD95L (sCD95L) decreased during the 1st week (41 ng(- l)) and increased after the 2nd week in all eight patients. It peaked during the 4th week (68.5 ng (- l)) and reached a plateau during the 12th week (76.2 ng (- l)). There are many possible explanations for not being able to detect a statistical significance, one of course being the small sample size. CONCLUSION:Promising results for anti-CD95L therapy have already been documented in lab studies with rodents. Anti-CD95L blocks the pro-apoptotic and proinflammatory activity of membrane-bound CD95L during the acute phase of SCI. We observed that sCD95L levels are elevated during the subacute and intermediate phases of SCI. It would be of great interest to study a larger group of patients to determine whether higher sCD95 levels are correlated with improved or impaired neurological outcome or with increasing levels of autoimmune components in peripheral blood.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Biglari B,Büchler A,Swing T,Biehl E,Roth HJ,Bruckner T,Schmidmaier G,Ferbert T,Gerner HJ,Moghaddam Adoi
10.1038/sc.2012.139subject
Has Abstractpub_date
2013-03-01 00:00:00pages
183-7issue
3eissn
1362-4393issn
1476-5624pii
sc2012139journal_volume
51pub_type
杂志文章相关文献
SPINAL CORD文献大全abstract：STUDY DESIGN:A retrospective study. OBJECTIVES:To investigate the risk factors of vesicoureteral reflux in the early stage of spinal cord injury. SETTING:Japan. METHODS:Urological evaluation, including cystography and urodynamic study was performed in patients in the early stage of spinal cord injury. The patients w...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101091
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:This study aims to understand the demographics, mode of trauma, hospital stay, complications, neurological improvement, mortality and expenditure incurred by Indian patients with spinal trauma and ankylosing spondylitis (AS). METHODS:Retrospective analysis of the patient data admitted to a tertiary referral ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.150
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVES:Hypertension (HTN) is an important risk factor for cardiovascular disease, a major cause of morbidity and mortality among people with spinal cord injury and disorders (SCI/D). Our study examined prevalence, associated factors, and pharmacological treatment of HTN in Veterans with SCI/D compared with a matche...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2012.122
更新日期：2013-02-01 00:00:00
abstract：STUDY DESIGN:Randomized, assessor-blinded trial. OBJECTIVES:To evaluate the effectiveness of a 6-week task-specific training programme on the abilities of people with chronic spinal cord injuries to sit unsupported. SETTING:NSW, Australia. METHODS:Thirty adults with spinal cord injuries of at least 1-year duration w...
journal_title：Spinal cord
pub_type： 杂志文章,随机对照试验
doi：10.1038/sc.2009.88
更新日期：2010-02-01 00:00:00
abstract：STUDY DESIGN:Retrospective chart review. OBJECTIVE:To analyze the role of sonography in detecting heterotopic ossification (HO) following spinal cord injury (SCI). SETTING:Department of Spinal Cord Injury and Department of General and Trauma Surgery, BG University Hospital Bergmannsheil Bochum, Ruhr University Bochum...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2016.93
更新日期：2017-01-01 00:00:00
abstract：STUDY DESIGN:A retrospective imaging and clinical study. OBJECTIVES:To evaluate the relationship between magnetic resonance imaging (MRI) features and neurological prognosis in patients with traumatic cervical spinal cord injury (CSCI) without major bone injury. METHODS:A total of 72 patients with CSCI without major ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.84
更新日期：2016-01-01 00:00:00
abstract：STUDY DESIGN:Prospective experimental. OBJECTIVES:To compare the cardiorespiratory responses with electrical stimulation (ES) producing either dynamic leg cycling or intermittent isometric leg contractions using the same ES protocol. SETTING:Sydney, Australia. METHODS:Eight paraplegics (T4-T11) performed ES exercise...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.85
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:Noxious stimuli activate small to medium-sized dorsal root ganglion (DRG) neurons. Intense noxious stimuli result in the release of substance P (SP) from the central terminals of these neurons. It binds to the neurokinin type 1 receptor (NK1r) and sensitises the dorsal horn neurons. SP is also released from ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.206
更新日期：2016-03-01 00:00:00
abstract：STUDY DESIGN:In the last years, there has been a change in the aetiology of spinal cord injury. There has been an increase in the number of elderly patients with spinal cord injuries caused by diseases or medical procedures. OBJECTIVE:The aim of this study is to investigate the frequency of the occurrence of iatrogeni...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2017.21
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:To evaluate rehabilitation outcome in a representative sample of older and younger SCI patients. DESIGN:Case series, consecutive sample, survey. SETTING:Tertiary care, spinal cord injury unit (National Spinal Injuries Centre), Stoke Mandeville Hospital. PARTICIPANTS:One hundred and forty-seven male and 45 ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101386
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To analyze the lipid and glycemic profiles in relation to age, time elapsed post injury and the level of injury in a group of patients with SCI. SUBJECTS:2135 subjects with SCI were recruited during the annual routine health check-up carried out at the Institut Guttmann of Badalona, in Spain. The patients we...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101390
更新日期：2003-03-01 00:00:00
abstract：:The case histories of two patients who had had a spinal cord injury (SCI) were selected by the senior author and sent to four experts in the field of SCI. Based on the 1992 American Spinal Injury Association (ASIA) and International Medical Society of Paraplegia (IMSOP) standards, the four participants plus the senior...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100449
更新日期：1997-05-01 00:00:00
abstract：STUDY DESIGN:This was a psychometric study. OBJECTIVES:To determine the validity of the Spanish version of the World Health Organization Quality of Life instrument (WHOQOL-BREF) for its use in persons with traumatic spinal cord injury and, as secondary objectives, to correlate the results with variables such as functi...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0139-2
更新日期：2018-10-01 00:00:00
abstract：:Management of the neuropathic bowel is one of the major issues in the treatment of patients with severe spinal cord injury (SCI). Pulsed irrigation evacuation (PIE) has been evaluated in several small studies for the clearing of fecal impactions in patients with a neuropathic bowel. We evaluated our experience with 39...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章
doi：10.1038/sj.sc.3100491
更新日期：1997-10-01 00:00:00
abstract：STUDY DESIGN:Prospective, observational OBJECTIVES: To evaluate agreement between a reference method (doubly labelled water, DLW) of total energy expenditure (TEE) and published equations for estimating energy requirements in acute spinal cord injury (SCI). SETTING:Victoria, Australia METHODS: Twenty participants (18 ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0253-9
更新日期：2019-07-01 00:00:00
abstract：STUDY DESIGN:Experimental study. OBJECTIVE:Individuals with spinal cord injuries (SCI) may present with impaired sympathetic control over thermoregulatory responses to environmental and exercise stressors, which can impact regional core temperature (Tcore) measurement. The purpose of this study was to investigate whet...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0257-5
更新日期：2019-07-01 00:00:00
abstract：STUDY DESIGN:Review. OBJECTIVES:To review literature on subjective well-being (SWB; mental health and life satisfaction) and on psychological and social support factors associated with these outcomes in people with spinal cord injury (SCI), in order to identify gaps in scientific knowledge and recommend research prior...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sc.2011.182
更新日期：2012-05-01 00:00:00
abstract：STUDY DESIGN:Case report OBJECTIVE:To examine the resolution of holocord myelopathy based on the hypothesis of altered cerebrospinal fluid (CSF) dynamics. SETTING:Seoul National University Hospital, Seoul, Korea. METHOD:We describe a case of thoracic stenosis with holocord myelopathy, which suggests an alternative m...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101522
更新日期：2003-12-01 00:00:00
abstract：STUDY DESIGN:Prospective cohort study. OBJECTIVES:To characterize the cerebrospinal fluid (CSF) concentrations of glial fibrillary acidic protein, neuron specific enolase (NSE), S-100β, tau and neurofilament heavy chain (NFH) within 24 h of an acute traumatic spinal cord injury (SCI), and to correlate these concentrat...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.26
更新日期：2014-06-01 00:00:00
abstract：STUDY DESIGN:Prospective, regional population-based study. OBJECTIVES:To provide the incidence, aetiology and injury characteristics of traumatic spinal cord injury (TSCI) in the City of Cape Town, South Africa. SETTING:All government-funded hospitals within the City of Cape Town, South Africa. METHODS:All survivors...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.51
更新日期：2015-09-01 00:00:00
abstract：STUDY DESIGN:Retrospective study of 432 patients admitted to our institution with a spinal injury over a 5-year period. OBJECTIVES:To present epidemiological data relating to this spinal population, reporting specifically on delayed admission and length of hospitalisation. SETTING:Royal National Orthopaedic Hospital,...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101734
更新日期：2005-07-01 00:00:00
abstract：:We report a case of a 32-year old woman with radicular symptoms associated with a low cervical chordoma. According to our knowledge this is the 10th case of low cervical chordoma reported in the literature. ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.1996.65
更新日期：1996-06-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional postal questionnaire study. OBJECTIVES:The aim of the study was to evaluate selected psychometric properties of a draft version of the Patient Participation in Rehabilitation Questionnaire (PPRQ) measuring patients' experiences of participation in care and rehabilitation. SETTING:Sweden...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.98
更新日期：2013-11-01 00:00:00
abstract：STUDY DESIGN:A case report. OBJECTIVES:To demonstrate stimulating action of F XIII in wound healing of complicated pressure sores. SETTING:A Spinal Cord Injury Center in Germany. METHODS:Clinical exam, clinical and photographic wound control, biochemical serum monitoring. RESULTS:Recurrent pressure sores in plegic ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101092
更新日期：2001-02-01 00:00:00
abstract：STUDY DESIGN:Prospective, population-based cohort study. OBJECTIVES:To determine the prevalence of selected complications following traumatic spinal cord injury during acute care and to identify the risk factors for pressure ulcers. SETTING:The only tertiary academic (Groote Schuur) hospital in the catchment region p...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2015.189
更新日期：2016-07-01 00:00:00
abstract：STUDY DESIGN:Prospective multidimensional study by means of: (1) clinical assessment, (2) parental-administered questionnaire for general health (CHQ-PF50), and (3) standardised disability measurements. OBJECTIVES:To assess the health-related quality of life (QoL) and disability in children with spina bifida (SB) and ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101707
更新日期：2005-04-01 00:00:00
abstract：STUDY DESIGN:Prospective, randomized, placebo-controlled, experimental study. OBJECTIVES:The issue of whether nitric oxide (NO) production is beneficial or deleterious on ischemic injuries of the central nervous system still remains doubtful. Vascular endothelial growth factor (VEGF) is known to induce the release of ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3102066
更新日期：2008-02-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional study OBJECTIVES: To determine clinical factors associated with telomere length in persons with chronic spinal cord injury (SCI). SETTING:Veterans Affairs Medical Center, Boston, MA. METHODS:Two hundred seventy-eight participants with chronic SCI provided blood samples for measurement of ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0336-7
更新日期：2019-12-01 00:00:00
abstract：STUDY DESIGN:A case report. SETTING:Department of Orthopaedic Surgery, Shiga University of Medical Science, Japan. PATIENT:A 13-year-old woman presented progressive weakness in the lower extremities, with predominance on the right. Magnetic resonance (MR) imaging revealed a huge syrinx. The patient also showed scolio...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101607
更新日期：2004-09-01 00:00:00
abstract：STUDY DESIGN:Multicenter, open, prospective, before-after study. OBJECTIVE:To assess the efficacy and safety of sildenafil therapy for erectile dysfunction in patients with spinal cord injury, and the association between the response to sildenafil and factors such as causes and levels of spinal cord injury, grade of A...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.sc.3101210
更新日期：2001-12-01 00:00:00
