IGF system in sarcomas: a crucial pathway with many unknowns to exploit for therapy.

abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

journal_title：Journal of molecular endocrinology

authors： Ackermann AM,Gannon M

更新日期：2007-02-01 00:00:00

abstract：:Evidence indicates that central regulation of food intake is well conserved along the vertebrate lineage, at least between teleost fish and mammals. However, several differences arise in the comparison between both groups. In this review, we describe similarities and differences between teleost fish and mammals on an ...

journal_title：Journal of molecular endocrinology

authors： Soengas JL,Cerdá-Reverter JM,Delgado MJ

更新日期：2018-05-01 00:00:00

abstract：:Leptin (Lep) is an anorexigenic hormone and regulates appetite-related neuropeptides in mammals. A number of neuropeptides have also been linked to appetite regulation in teleost fish, but Lep signaling activation and effects on appetite-regulating neurons are poorly elucidated in early vertebrates. This study uses ce...

journal_title：Journal of molecular endocrinology

authors： Gong N,Jönsson E,Björnsson BT

更新日期：2016-04-01 00:00:00

abstract：:Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the gonadotrope cell and act on the gonad in a sequential and synergistic manner to initiate sexual maturation and maintain cyclic reproductive functi...

journal_title：Journal of molecular endocrinology

authors： Burger LL,Haisenleder DJ,Dalkin AC,Marshall JC

更新日期：2004-12-01 00:00:00

abstract：:Parathyroid hormone-related peptide (PTHrP) is thought to be responsible for hypercalcemia in some patients with malignant tumors. The PTHrP gene has seven exons, giving rise to three types of PTHrP isoform through alternative splicing. We studied the expression of mRNAs in 14 human cell lines using the reverse transc...

journal_title：Journal of molecular endocrinology

authors： Nakamura M,Hashimoto T,Furuyama J,Kakudo K

更新日期：1995-12-01 00:00:00

abstract：:In embryonic growth cartilage, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) participate in a negative feedback loop that regulates chondrocyte differentiation. Postnatally, this region undergoes major structural and functional changes. To explore the organization of the Ihh–PTHrP system in pos...

journal_title：Journal of molecular endocrinology

authors： Chau M,Forcinito P,Andrade AC,Hegde A,Ahn S,Lui JC,Baron J,Nilsson O

更新日期：2011-08-01 00:00:00

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:Oxytocin (OXT) is a peptide hormone that plays a central role in the regulation of parturition and lactation. OXT signaling is mediated by OXT receptor (OXTR), which shows species- and tissue-specific expressions and gene regulation. In the present study, we examined the synthesis of OXT and OXTR in human placenta tis...

journal_title：Journal of molecular endocrinology

authors： Kim SC,Lee JE,Kang SS,Yang HS,Kim SS,An BS

更新日期：2017-10-01 00:00:00

abstract：:The subcellular distribution of steroidogenic enzymes has so far been studied mostly in classical endocrine glands and in the placenta. In the peripheral intracrine organs which synthesize sex steroids there is no indication about the organelles which contain the enzymes involved in steroid biosynthesis. We have thus ...

journal_title：Journal of molecular endocrinology

authors： Pelletier G,Luu-The V,El-Alfy M,Li S,Labrie F

更新日期：2001-02-01 00:00:00

abstract：:Impaired insulin action has been associated with diabetes, dyslipidemia and atherosclerotic vascular disease. The expression of insulin resistance results from the interaction of environmental and genetic factors. Human hepatic lipase (HL) is a lipolytic enzyme that plays a role in the metabolism of several lipoprotei...

journal_title：Journal of molecular endocrinology

authors： Gómez P,Pérez-Jiménez F,Marín C,Moreno JA,Gómez MJ,Bellido C,Pérez-Martínez P,Fuentes F,Paniagua JA,López-Miranda J

更新日期：2005-04-01 00:00:00

abstract：:cDNA clones coding for rabbit prolactin were isolated from a pituitary library using a rat prolactin RNA probe. One cDNA contained 873 bases including the entire coding sequence of rabbit prolactin, its signal peptide and the 5' and 3' untranslated regions of 44 and 145 nucleotides respectively. The deduced amino acid...

journal_title：Journal of molecular endocrinology

authors： Gabou L,Boisnard M,Gourdou I,Jammes H,Dulor JP,Djiane J

更新日期：1996-02-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations cause a syndrome with ...

journal_title：Journal of molecular endocrinology

authors： Lee ME,Tepede AA,Mandl A,Weinstein LS,Del Rivero J,Agarwal SK,Blau JE

更新日期：2020-08-01 00:00:00

abstract：:The classical concept of the renin-angiotensin system (RAS) is that of a blood-borne cascade, whose final and bioactive product, angiotensin II, plays an important endocrine role in the maintenance of blood pressure and electrolyte as well as fluid balance. In addition to this circulating RAS, there are an increasing ...

journal_title：Journal of molecular endocrinology

authors： Leung PS,Carlsson PO

更新日期：2001-06-01 00:00:00

abstract：:It has been demonstrated that transforming growth factor-β (TGFβ) and other members of TGFβ superfamily play an important role in thyroid proliferative diseases. The deficiencies of SMAD4 are responsible to accelerate the malignant progression of neoplastic lesions in several types of tumors. Therefore, the objective ...

journal_title：Journal of molecular endocrinology

authors： D'Inzeo S,Nicolussi A,Ricci A,Mancini P,Porcellini A,Nardi F,Coppa A

更新日期：2010-10-01 00:00:00

abstract：:The pancreatic regenerating (reg) gene is proposed to be involved in pancreatic beta-cell growth. Up- or down-regulation of reg gene expression has been shown to parallel variations in beta-cell mass and function in the adult pancreas. In several species at least two nonallelic reg genes have been identified. In this ...

journal_title：Journal of molecular endocrinology

authors： Perfetti R,Raygada M,Wang Y,Zenilman ME,Egan JM,Denno KM,Sadler TW,Shuldiner AR

更新日期：1996-08-01 00:00:00

abstract：:The diagnosis of conventional and oncocytic poorly differentiated (oPD) thyroid carcinomas is difficult. The aim of this study is to characterise their largely unknown miRNA expression profile and to compare it with well-differentiated thyroid tumours, as well as to identify miRNAs which could potentially serve as dia...

journal_title：Journal of molecular endocrinology

authors： Dettmer MS,Perren A,Moch H,Komminoth P,Nikiforov YE,Nikiforova MN

更新日期：2014-03-06 00:00:00

abstract：:In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the generated mouse lines with hyperaldosteronism was phenotypically and geneti...

journal_title：Journal of molecular endocrinology

authors： Perez-Rivas LG,Rhayem Y,Sabrautzki S,Hantel C,Rathkolb B,Hrabě de Angelis M,Reincke M,Beuschlein F,Spyroglou A

更新日期：2017-02-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The hormone-specific FSHβ-subunit is non-covalently associated with the common α-subunit that is also present in the luteinizing hormone (LH)...

journal_title：Journal of molecular endocrinology

authors： Das N,Kumar TR

更新日期：2018-04-01 00:00:00

abstract：:It has been suggested that the thyroid itself may contribute to the inflammatory process observed in autoimmune thyroiditis by releasing the cytokines interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8), but studies of cytokine gene expression in thyrocytes have been limited and conflicting...

journal_title：Journal of molecular endocrinology

authors： Watson PF,Pickerill AP,Davies R,Weetman AP

更新日期：1995-08-01 00:00:00

abstract：:In previous studies we demonstrated that IGF-I induces proliferation of pituitary lactotrophs. In addition to its mitotrophic actions, IGF-I is known to prevent apoptosis induced by diverse stimuli in several cell types. In this study, we investigated the action of IGF-I on pituitary cell survival and the intracellula...

journal_title：Journal of molecular endocrinology

authors： Fernández M,Sánchez-Franco F,Palacios N,Sánchez I,Fernández C,Cacicedo L

更新日期：2004-08-01 00:00:00

abstract：:There is evidence that insulin-like growth factor-binding protein (IGFBP-2), a modulator of the actions of IGFs, also has IGF-independent effects in human tumor cell lines. These involve specific binding of IGFBP-2 to alpha5beta1-integrin, followed by alterations in the phosphorylation status of downstream signaling m...

journal_title：Journal of molecular endocrinology

authors： Frommer KW,Reichenmiller K,Schutt BS,Hoeflich A,Ranke MB,Dodt G,Elmlinger MW

更新日期：2006-08-01 00:00:00

abstract：:Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

journal_title：Journal of molecular endocrinology

authors： Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

更新日期：2009-02-01 00:00:00

abstract：:Luteotropic glycoprotein hormones (LGH) include luteinizing hormone (LH) and chorionic gonadotropin (CG). The order Primates is the only phylogenetic clad known to exhibit more than one LGHbeta subunit gene per haploid genome. In the present study, we report the discovery of a second case of LGHbeta gene replication, ...

journal_title：Journal of molecular endocrinology

authors： Lund LA,Sherman GB

更新日期：1998-08-01 00:00:00

abstract：:Previous studies have demonstrated that TRH is a potent stimulator of alpha-MSH secretion from frog pituitary melanotrophs. In order to determine the intracellular events responsible for TRH-evoked alpha-MSH release, we have investigated the effect of TRH on polyphosphoinositide breakdown in frog pars intermedia. Neur...

journal_title：Journal of molecular endocrinology

authors： Desrues L,Tonon MC,Vaudry H

更新日期：1990-10-01 00:00:00

abstract：:Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid as the 'hormone of pregnancy'. It was the unique 'pro-gestational' bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a fun...

journal_title：Journal of molecular endocrinology

authors： DeMayo FJ,Lydon JP

更新日期：2020-07-01 00:00:00

abstract：:Two forms of prolactin (tiPRLI and tiPRLII), with only 69% sequence identity, have been previously described in the cichlid fish tilapia (Oreochromis species). In the present study we have attempted to investigate the biological activity of these two prolactin forms during adaptation to a hyperosmotic environment. For...

journal_title：Journal of molecular endocrinology

authors： Auperin B,Rentier-Delrue F,Martial JA,Prunet P

更新日期：1994-02-01 00:00:00

abstract：:Abnormal placental function is well-established as a major cause for poor pregnancy outcome. Placental blood flow within the maternal uteroplacental compartment, the fetoplacental circulation or both is a vital factor in mediating placental function. Impairment in flow in either or both vasculatures is a significant r...

journal_title：Journal of molecular endocrinology

authors： Li Y,Lorca RA,Su EJ

更新日期：2018-01-01 00:00:00

abstract：:Twenty-five years have elapsed since the calcium-sensing receptor (CaSR) was first identified in bovine parathyroid and the receptor is now recognized as a fundamental contributor to extracellular Ca2+ (Ca2+ e) homeostasis, regulating parathyroid hormone release and urinary calcium excretion. The CaSR is a class C G-p...

journal_title：Journal of molecular endocrinology

authors： Gorvin CM

更新日期：2019-08-01 00:00:00

abstract：:We used the Crm1 inhibitor leptomycin B (LMB) to examine a possible involvement of nuclear export in estrogen receptor alpha (ER) level and function in MCF-7 breast carcinoma cells. As revealed by immunofluorescence microscopy and western blotting with anti-ER antibodies, LMB produced an accumulation of ER in cell nuc...

journal_title：Journal of molecular endocrinology

authors： Nonclercq D,Journé F,Laïos I,Chaboteaux C,Toillon RA,Leclercq G,Laurent G

更新日期：2007-08-01 00:00:00

abstract：:Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid gland in response to changes in ionized calcium (Ca(2+)) concentrations. In this study, we measured PTH secretion, and PTH mRNA and calcium-sensing receptor (CaR) mRNA expression by equine parathyroid chief cells in vitro. We also evaluated th...

journal_title：Journal of molecular endocrinology

authors： Toribio RE,Kohn CW,Capen CC,Rosol TJ

更新日期：2003-12-01 00:00:00