Abstract:
:Translation in an academic environment requires a support system--people, goals, models, partnerships, and infrastructures--that will push promising basic science and technology projects forward into the clinic.
journal_name
Sci Transl Medjournal_title
Science translational medicineauthors
Volk HD,Stevens MM,Mooney DJ,Grainger DW,Duda GNdoi
10.1126/scitranslmed.aaa2049subject
Has Abstractpub_date
2015-04-08 00:00:00pages
282cm2issue
282eissn
1946-6234issn
1946-6242pii
7/282/282cm2journal_volume
7pub_type
杂志文章abstract::Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T cell activation. Although evidence for an active immune response, including infiltration with CD8(+) T cells, can be found in a subset of patients, those tumors are nonetheless not immunologically rejecte...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3006504
更新日期:2013-08-28 00:00:00
abstract::PTEN (phosphatase and tensin homolog) loss of function is the most common genetic aberration in endometrioid endometrial carcinomas. In addition to its well-described role in cell signaling, PTEN is involved in the maintenance of genomic stability. Loss of PTEN function causes defects in repair of DNA double-strand br...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3001538
更新日期:2010-10-13 00:00:00
abstract::A study in this issue of Science Translational Medicine provides fresh insight into the role of autophagy in cancer. Kon et al. show that a specific type of autophagy, called chaperone-mediated autophagy (CMA), is consistently elevated in tumors and is required for optimal tumor growth and metastasis. Selective inhibi...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.3003390
更新日期:2011-11-16 00:00:00
abstract::Increased iron in cancer cells drives selective sensitization of tumors to ascorbate treatment to prolong survival. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aan2778
更新日期:2017-04-12 00:00:00
abstract::Sepsis remains a major public health problem with no major therapeutic advances over the last several decades. The clinical and biological heterogeneity of sepsis have limited success of potential new therapies. Accordingly, there is considerable interest in developing a precision medicine approach to inform more rati...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aax9000
更新日期:2019-11-13 00:00:00
abstract::Inhaled drugs offer advantages, such as rapid onset of action, but require formulations and delivery systems that reproducibly and conveniently administer the drug. CVT-301 is a powder formulation of levodopa delivered by a breath-actuated inhaler that has been developed for treating OFF episodes (motor fluctuations b...
journal_title:Science translational medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1126/scitranslmed.aad8858
更新日期:2016-10-12 00:00:00
abstract::Resveratrol is widely promoted as a potential cancer chemopreventive agent, but a lack of information on the optimal dose prohibits rationally designed trials to assess efficacy. To challenge the assumption that "more is better," we compared the pharmacokinetics and activity of a dietary dose with an intake 200 times ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaa7619
更新日期:2015-07-29 00:00:00
abstract::Regular physical activity and especially aerobic exercise are associated with reduced risk of disease and enhanced longevity, but the molecular mechanisms of these health benefits remain obscure. A comprehensive metabolomic approach was used to characterize the changes in blood levels of >200 metabolites upon vigorous...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3001188
更新日期:2010-07-21 00:00:00
abstract::A new type of biological clock regulates the unfolded protein response. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aan6728
更新日期:2017-06-28 00:00:00
abstract::Anti-CTLA-4 treatment improves the survival of patients with advanced-stage melanoma. However, although the anti-CTLA-4 antibody ipilimumab is now an approved treatment for patients with metastatic disease, it remains unknown by which mechanism it boosts tumor-specific T cell activity. In particular, it is unclear whe...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3008918
更新日期:2014-09-17 00:00:00
abstract::New insights into the mechanism of action of ebselen, a small-molecule antivirulence agent that reduces disease pathology in a mouse model of Clostridium difficile infection, suggest a different molecular target may be responsible for its efficacy. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aad8926
更新日期:2016-12-21 00:00:00
abstract::Chemotherapy-induced cardiotoxicity (CIC) is a common clinical problem that compromises effective anticancer therapies. Many chemotherapeutics (including anthracyclines, such as doxorubicin) induce the proapoptotic transcription factor p53 in the tumor and nonspecifically in the heart, promoting heart failure. Althoug...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aau8866
更新日期:2019-02-06 00:00:00
abstract::We tested the hypothesis that ex vivo hepatocyte gene therapy can correct the metabolic disorder in fumarylacetoacetate hydrolase-deficient (Fah(-/-)) pigs, a large animal model of hereditary tyrosinemia type 1 (HT1). Recipient Fah(-/-) pigs underwent partial liver resection and hepatocyte isolation by collagenase dig...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaf3838
更新日期:2016-07-27 00:00:00
abstract::The invasive nature of glioblastoma (GBM) represents a major clinical challenge contributing to poor outcomes. Invasion of GBM into healthy tissue restricts chemotherapeutic access and complicates surgical resection. Here, we test the hypothesis that an effective anti-invasive agent can "contain" GBM and increase the ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3003016
更新日期:2012-03-28 00:00:00
abstract::The tumor microenvironment is host to a complex network of cytokines that contribute to shaping the intratumoral immune reaction. Chromosomal gains and losses, coupled with expression analysis, of 59 cytokines and receptors and their functional networks were investigated in colorectal cancers. Changes in local express...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3007240
更新日期:2014-03-19 00:00:00
abstract::Advances in understanding the genetics and underlying pathology of the catastrophic childhood epilepsies are pointing toward treatments. ...
journal_title:Science translational medicine
pub_type:
doi:10.1126/scitranslmed.3010531
更新日期:2014-11-12 00:00:00
abstract::Adoptive cell transfer of ex vivo expanded regulatory T cells (Tregs) has shown immense potential in animal models of auto- and alloimmunity. However, the effective translation of such Treg therapies to the clinic has been slow. Because Treg homeostasis is known to require continuous T cell receptor (TCR) ligation and...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaw4744
更新日期:2020-11-11 00:00:00
abstract::Most cancer deaths arise from metastases as a result of circulating tumor cells (CTCs) spreading from the primary tumor to vital organs. Despite progress in cancer prognosis, the role of CTCs in early disease diagnosis is unclear because of the low sensitivity of CTC assays. We demonstrate the high sensitivity of the ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aat5857
更新日期:2019-06-12 00:00:00
abstract::Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors,...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3001902
更新日期:2011-05-04 00:00:00
abstract::Retinal prosthetic implants are the only approved treatment for retinitis pigmentosa, a disease of the eye that causes blindness through gradual degeneration of photoreceptors. An array of microelectrodes triggered by input from a camera stimulates surviving retinal neurons, with each electrode acting as a pixel. Unin...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aac4877
更新日期:2015-12-16 00:00:00
abstract::An analysis of four regions in four countries suggests that the best way to mitigate disruption of the pharmaceutical industry is not to ignore or stem it but to sponsor initiatives that keep scientists engaged. ...
journal_title:Science translational medicine
pub_type: 杂志文章,评审
doi:10.1126/scitranslmed.aaa3679
更新日期:2015-05-06 00:00:00
abstract::A pilot study of a handheld fluorescence endomicroscope demonstrates both in vivo imaging and differentiation of normal from precancerous cervical tissue. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aal4989
更新日期:2017-01-11 00:00:00
abstract::Heparin-based anticoagulant drugs have been widely used for the prevention of blood clotting during surgical procedures and for the treatment of thromboembolic events. However, bleeding risks associated with these anticoagulants demand continuous monitoring and neutralization with suitable antidotes. Protamine, the on...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3009427
更新日期:2014-10-29 00:00:00
abstract::The aim of treatment in congenital adrenal hyperplasia is to suppress excess adrenal androgens while achieving physiological glucocorticoid replacement. However, current glucocorticoid replacement regimes are inadequate because doses sufficient to suppress excess androgens almost invariably induce adverse metabolic ef...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaf9074
更新日期:2016-08-17 00:00:00
abstract::Centronuclear myopathies (CNMs) are severe diseases characterized by muscle weakness and myofiber atrophy. Currently, there are no approved treatments for these disorders. Mutations in the phosphoinositide 3-phosphatase myotubularin (MTM1) are responsible for X-linked CNM (XLCNM), also called myotubular myopathy, wher...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aav1866
更新日期:2019-03-20 00:00:00
abstract::The clinical application of cytokine therapies for cancer treatment remains limited due to severe adverse reactions and insufficient therapeutic effects. Although cytokine localization by intratumoral administration could address both issues, the rapid escape of soluble cytokines from the tumor invariably subverts thi...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaw2614
更新日期:2019-06-26 00:00:00
abstract::About 25% of high-grade cervical intraepithelial neoplasias (CIN2/3) caused by human papillomavirus serotype 16 (HPV16) undergo complete spontaneous regression. However, to date, therapeutic vaccination strategies for HPV disease have yielded limited success when measured by their ability to induce robust peripheral b...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3007323
更新日期:2014-01-29 00:00:00
abstract::The elevation of carbon dioxide (CO2) in tissues and the bloodstream (hypercapnia) occurs in patients with severe lung diseases, including chronic obstructive pulmonary disease (COPD). Whereas hypercapnia has been recognized as a marker of COPD severity, a role for hypercapnia in disease pathogenesis remains unclear. ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aat1662
更新日期:2018-09-05 00:00:00
abstract::Down syndrome (DS) is among the most frequent genetic causes of intellectual disability, and ameliorating this deficit is a major goal in support of people with trisomy 21. The Ts65Dn mouse recapitulates some major brain structural and behavioral phenotypes of DS, including reduced size and cellularity of the cerebell...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3005983
更新日期:2013-09-04 00:00:00
abstract::The recent Perspective entitled "Power of rare diseases: Found in translation" undervalues the contributions of academic research in first-in-human studies. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.3007911
更新日期:2014-01-15 00:00:00