当前位置： SCI文献检索 > Science Translational Medicine期刊下所有文献 > Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

Abstract：

:Anti-CTLA-4 treatment improves the survival of patients with advanced-stage melanoma. However, although the anti-CTLA-4 antibody ipilimumab is now an approved treatment for patients with metastatic disease, it remains unknown by which mechanism it boosts tumor-specific T cell activity. In particular, it is unclear whether treatment amplifies previously induced T cell responses or whether it induces new tumor-specific T cell reactivities. Using a combination ultraviolet (UV)-induced peptide exchange and peptide-major histocompatibility complex (pMHC) combinatorial coding, we monitored immune reactivity against a panel of 145 melanoma-associated epitopes in a cohort of patients receiving anti-CTLA-4 treatment. Comparison of pre- and posttreatment T cell reactivities in peripheral blood mononuclear cell samples of 40 melanoma patients demonstrated that anti-CTLA-4 treatment induces a significant increase in the number of detectable melanoma-specific CD8 T cell responses (P = 0.0009). In striking contrast, the magnitude of both virus-specific and melanoma-specific T cell responses that were already detected before start of therapy remained unaltered by treatment (P = 0.74). The observation that anti-CTLA-4 treatment induces a significant number of newly detected T cell responses-but only infrequently boosts preexisting immune responses-provides strong evidence for anti-CTLA-4 therapy-enhanced T cell priming as a component of the clinical mode of action.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Kvistborg P,Philips D,Kelderman S,Hageman L,Ottensmeier C,Joseph-Pietras D,Welters MJ,van der Burg S,Kapiteijn E,Michielin O,Romano E,Linnemann C,Speiser D,Blank C,Haanen JB,Schumacher TN

doi

10.1126/scitranslmed.3008918

subject

Has Abstract

pub_date

2014-09-17 00:00:00

pages

254ra128

issue

254

eissn

1946-6234

issn

1946-6242

pii

6/254/254ra128

journal_volume

6

pub_type

杂志文章

相关文献

Science Translational Medicine文献大全
  • Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration.

    abstract：:Retinal prosthetic implants are the only approved treatment for retinitis pigmentosa, a disease of the eye that causes blindness through gradual degeneration of photoreceptors. An array of microelectrodes triggered by input from a camera stimulates surviving retinal neurons, with each electrode acting as a pixel. Unin...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aac4877

    authors： Weitz AC,Nanduri D,Behrend MR,Gonzalez-Calle A,Greenberg RJ,Humayun MS,Chow RH,Weiland JD

    更新日期：2015-12-16 00:00:00

  • Translational cancer research comes of age in Latin America.

    abstract：:The U.S.-Latin America Cancer Research Network strives to expand translational research capabilities and forge new collaborations. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aad5859

    authors： Investigators of the US–Latin America Cancer Research Network.

    更新日期：2015-12-23 00:00:00

  • Programmable probiotics for detection of cancer in urine.

    abstract：:Rapid advances in the forward engineering of genetic circuitry in living cells has positioned synthetic biology as a potential means to solve numerous biomedical problems, including disease diagnosis and therapy. One challenge in exploiting synthetic biology for translational applications is to engineer microbes that ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaa3519

    authors： Danino T,Prindle A,Kwong GA,Skalak M,Li H,Allen K,Hasty J,Bhatia SN

    更新日期：2015-05-27 00:00:00

  • STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.

    abstract：:Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 (signal transducer and activator of transcription 6) signaling pathways to induce r...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaa4306

    authors： Fu J,Kanne DB,Leong M,Glickman LH,McWhirter SM,Lemmens E,Mechette K,Leong JJ,Lauer P,Liu W,Sivick KE,Zeng Q,Soares KC,Zheng L,Portnoy DA,Woodward JJ,Pardoll DM,Dubensky TW Jr,Kim Y

    更新日期：2015-04-15 00:00:00

  • The gracefully aging immune system.

    abstract：:Prolonged life expectancy in the 20th century has been one of humankind's greatest triumphs. However, the substantial increase in the human life span has ushered in a new concern: healthy aging. Because infectious diseases prominently contribute to morbidity in the particularly vulnerable elderly population, strategie...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.3005624

    authors： Boraschi D,Aguado MT,Dutel C,Goronzy J,Louis J,Grubeck-Loebenstein B,Rappuoli R,Del Giudice G

    更新日期：2013-05-15 00:00:00

  • Prevention of cystic fibrosis: The beginning of the end?

    abstract：:Prenatal and postnatal treatment with a CFTR modifier attenuates pathological changes in a ferret model of cystic fibrosis (Sun et al., this issue). ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章,评审

    doi：10.1126/scitranslmed.aax2361

    authors： Ferkol TW

    更新日期：2019-03-27 00:00:00

  • A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.

    abstract：:Current HIV vaccines are only partially efficacious, presenting an opportunity to identify correlates of protection and, thereby, potential insight into mechanisms that prevent HIV acquisition. Two independent preclinical challenge studies in nonhuman primates (NHPs) previously showed partial efficacy of a mosaic aden...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaw4236

    authors： Ehrenberg PK,Shangguan S,Issac B,Alter G,Geretz A,Izumi T,Bryant C,Eller MA,Wegmann F,Apps R,Creegan M,Bolton DL,Sekaly RP,Robb ML,Gramzinski RA,Pau MG,Schuitemaker H,Barouch DH,Michael NL,Thomas R

    更新日期：2019-08-28 00:00:00

  • Fluid assessment in dialysis patients by point-of-care magnetic relaxometry.

    abstract：:Magnetic resonance imaging (MRI) is a powerful diagnostic tool, but its use is restricted to the scanner suite. Here, we demonstrate that a bedside nuclear magnetic resonance (NMR) sensor can assess fluid status changes in individuals at a fraction of the time and cost compared to MRI. Our study recruited patients wit...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aau1749

    authors： Colucci LA,Corapi KM,Li M,Parada XV,Allegretti AS,Lin HY,Ausiello DA,Rosen MS,Cima MJ

    更新日期：2019-07-24 00:00:00

  • Could exercise metabolomics pave the way for gymnomimetics?

    abstract：:Regular physical activity and especially aerobic exercise are associated with reduced risk of disease and enhanced longevity, but the molecular mechanisms of these health benefits remain obscure. A comprehensive metabolomic approach was used to characterize the changes in blood levels of >200 metabolites upon vigorous...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001188

    authors： Burke MF,Dunbar RL,Rader DJ

    更新日期：2010-07-21 00:00:00

  • Lost but making progress--Where will new analgesic drugs come from?

    abstract：:There is a critical need for effective new pharmacotherapies for pain. The paucity of new drugs successfully reaching the clinic calls for a reassessment of current analgesic drug discovery approaches. Many points early in the discovery process present significant hurdles, making it critical to exploit advances in pai...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.3008320

    authors： Borsook D,Hargreaves R,Bountra C,Porreca F

    更新日期：2014-08-13 00:00:00

  • Development of personalized tumor biomarkers using massively parallel sequencing.

    abstract：:Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. The evaluation of patient-specific translocations in leukemias and lymphomas has revolutionized diagnostics for these diseases. We have developed a method, called personalized analysis of rearranged ends (PARE...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3000702

    authors： Leary RJ,Kinde I,Diehl F,Schmidt K,Clouser C,Duncan C,Antipova A,Lee C,McKernan K,De La Vega FM,Kinzler KW,Vogelstein B,Diaz LA Jr,Velculescu VE

    更新日期：2010-02-24 00:00:00

  • Patients with autism spectrum disorders display reproducible functional connectivity alterations.

    abstract：:Despite the high clinical burden, little is known about pathophysiology underlying autism spectrum disorder (ASD). Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have found atypical synchronization of brain activity in ASD. However, no consensus has been reached on the nature and clinical...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aat9223

    authors： Holiga Š,Hipp JF,Chatham CH,Garces P,Spooren W,D'Ardhuy XL,Bertolino A,Bouquet C,Buitelaar JK,Bours C,Rausch A,Oldehinkel M,Bouvard M,Amestoy A,Caralp M,Gueguen S,Ly-Le Moal M,Houenou J,Beckmann CF,Loth E,Murphy D

    更新日期：2019-02-27 00:00:00

  • Porous polymeric platform repairs primates after spinal cord injury.

    abstract：:Amine-containing polymers immobilized on mesh and placed at trauma sites scavenge biomolecules that initiate a damaging immune response. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aam6068

    authors： Ulery BD

    更新日期：2017-02-22 00:00:00

  • How to handle an industry in disruption: Intervene or laissez-faire?

    abstract：:An analysis of four regions in four countries suggests that the best way to mitigate disruption of the pharmaceutical industry is not to ignore or stem it but to sponsor initiatives that keep scientists engaged. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aaa3679

    authors： Munos B

    更新日期：2015-05-06 00:00:00

  • Translating glutamate: from pathophysiology to treatment.

    abstract：:The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian brain and is responsible for most corticocortical and corticofugal neurotransmission. Disturbances in glutamatergic function have been implicated in the pathophysiology of several neuropsychiatric disorders-including schizophrenia, ...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.3002804

    authors： Javitt DC,Schoepp D,Kalivas PW,Volkow ND,Zarate C,Merchant K,Bear MF,Umbricht D,Hajos M,Potter WZ,Lee CM

    更新日期：2011-09-28 00:00:00

  • Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production.

    abstract：:Elevated serum levels of both total and allergen-specific immunoglobulin E (IgE) correlate with atopic diseases such as allergic rhinitis and allergic asthma. Neutralization of IgE by anti-IgE antibodies can effectively treat allergic asthma. Preclinical studies indicate that targeting membrane IgE-positive cells with...

    journal_title：Science translational medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1126/scitranslmed.3008961

    authors： Gauvreau GM,Harris JM,Boulet LP,Scheerens H,Fitzgerald JM,Putnam WS,Cockcroft DW,Davis BE,Leigh R,Zheng Y,Dahlén B,Wang Y,Maciuca R,Mayers I,Liao XC,Wu LC,Matthews JG,O'Byrne PM

    更新日期：2014-07-02 00:00:00

  • IgH sequences in common variable immune deficiency reveal altered B cell development and selection.

    abstract：:Common variable immune deficiency (CVID) is the most common symptomatic primary immune deficiency, affecting ~1 in 25,000 persons. These patients suffer from impaired antibody responses, autoimmunity, and susceptibility to lymphoid cancers. To explore the cellular basis for these clinical phenotypes, we conducted high...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aab1216

    authors： Roskin KM,Simchoni N,Liu Y,Lee JY,Seo K,Hoh RA,Pham T,Park JH,Furman D,Dekker CL,Davis MM,James JA,Nadeau KC,Cunningham-Rundles C,Boyd SD

    更新日期：2015-08-26 00:00:00

  • Shining new light on migraine.

    abstract：:Migraine-related photophobia is multifaceted and may be mediated by numerous pathways. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aan8206

    authors： Lehtinen MK

    更新日期：2017-07-12 00:00:00

  • Comment on "Power of rare diseases: found in translation".

    abstract：:The recent Perspective entitled "Power of rare diseases: Found in translation" undervalues the contributions of academic research in first-in-human studies. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.3007911

    authors： van der Meer JW,Simon A,Dinarello CA

    更新日期：2014-01-15 00:00:00

  • ER stress in prostate cancer: A therapeutically exploitable vulnerability?

    abstract：:Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen et al, this issue). ...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aat3975

    authors： Logothetis C,Aparicio A,Thompson TC

    更新日期：2018-05-02 00:00:00

  • A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.

    abstract：:Retinal pigment epithelium (RPE) dysfunction and loss are a hallmark of non-neovascular age-related macular degeneration (NNAMD). Without the RPE, a majority of overlying photoreceptors ultimately degenerate, leading to severe, progressive vision loss. Clinical and histological studies suggest that RPE replacement str...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aao4097

    authors： Kashani AH,Lebkowski JS,Rahhal FM,Avery RL,Salehi-Had H,Dang W,Lin CM,Mitra D,Zhu D,Thomas BB,Hikita ST,Pennington BO,Johnson LV,Clegg DO,Hinton DR,Humayun MS

    更新日期：2018-04-04 00:00:00

  • Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer.

    abstract：:Therapeutic intravesical instillation of bacillus Calmette-Guérin (BCG) is effective at triggering inflammation and eliciting successful tumor immunity in patients with non-muscle invasive bladder cancer, with 50 to 70% clinical response. Therapeutic success relies on repeated instillations of live BCG administered as...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3003586

    authors： Biot C,Rentsch CA,Gsponer JR,Birkhäuser FD,Jusforgues-Saklani H,Lemaître F,Auriau C,Bachmann A,Bousso P,Demangel C,Peduto L,Thalmann GN,Albert ML

    更新日期：2012-06-06 00:00:00

  • Biotechnology: delivering on the promise.

    abstract：:The research and development of innovative new therapies are expensive and risky processes, and companies require substantial resources if they are to translate basic science into modern biomedical products. When resources are limited, as in the current economic climate, biotechnology start-up companies are often amon...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3000357

    authors： Greenwood JC

    更新日期：2010-01-06 00:00:00

  • Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.

    abstract：:Hepatitis B virus (HBV)-induced hepatitis and carcinogen-induced hepatocellular carcinoma (HCC) are associated with serum androgen concentration. However, how androgen or the androgen receptor (AR) contributes to HBV-induced hepatocarcinogenesis remains unclear. We found that hepatic AR promotes HBV-induced hepatocarc...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001143

    authors： Wu MH,Ma WL,Hsu CL,Chen YL,Ou JH,Ryan CK,Hung YC,Yeh S,Chang C

    更新日期：2010-05-19 00:00:00

  • In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.

    abstract：:Most cancer deaths arise from metastases as a result of circulating tumor cells (CTCs) spreading from the primary tumor to vital organs. Despite progress in cancer prognosis, the role of CTCs in early disease diagnosis is unclear because of the low sensitivity of CTC assays. We demonstrate the high sensitivity of the ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aat5857

    authors： Galanzha EI,Menyaev YA,Yadem AC,Sarimollaoglu M,Juratli MA,Nedosekin DA,Foster SR,Jamshidi-Parsian A,Siegel ER,Makhoul I,Hutchins LF,Suen JY,Zharov VP

    更新日期：2019-06-12 00:00:00

  • Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans.

    abstract：:Medical devices and implants made of synthetic materials can induce an immune-mediated process when implanted in the body called the foreign body response, which results in formation of a fibrous capsule around the implant. To explore the immune and stromal connections underpinning the foreign body response, we analyz...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aax3799

    authors： Chung L,Maestas DR Jr,Lebid A,Mageau A,Rosson GD,Wu X,Wolf MT,Tam AJ,Vanderzee I,Wang X,Andorko JI,Zhang H,Narain R,Sadtler K,Fan H,Čiháková D,Le Saux CJ,Housseau F,Pardoll DM,Elisseeff JH

    更新日期：2020-04-15 00:00:00

  • Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.

    abstract：:Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by loss of activity of α-l-iduronidase and attendant accumulation of the glycosaminoglycans dermatan sulfate and heparan sulfate. Current treatments are suboptimal and do not address residual disease including corneal clouding, skeletal deformi...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001380

    authors： Dierenfeld AD,McEntee MF,Vogler CA,Vite CH,Chen AH,Passage M,Le S,Shah S,Jens JK,Snella EM,Kline KL,Parkes JD,Ware WA,Moran LE,Fales-Williams AJ,Wengert JA,Whitley RD,Betts DM,Boal AM,Riedesel EA,Gross W,Ellinwo

    更新日期：2010-12-01 00:00:00

  • Key elements for nourishing the translational research environment.

    abstract：:Translation in an academic environment requires a support system--people, goals, models, partnerships, and infrastructures--that will push promising basic science and technology projects forward into the clinic. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaa2049

    authors： Volk HD,Stevens MM,Mooney DJ,Grainger DW,Duda GN

    更新日期：2015-04-08 00:00:00

  • Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy.

    abstract：:Cancer clinics currently use high-dose stereotactic body radiation therapy as a curative treatment for several kinds of cancers. However, the contribution of vascular endothelial cells to tumor response to radiation remains controversial. Using dual recombinase technology, we generated primary sarcomas in mice with ta...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaa4214

    authors： Moding EJ,Castle KD,Perez BA,Oh P,Min HD,Norris H,Ma Y,Cardona DM,Lee CL,Kirsch DG

    更新日期：2015-03-11 00:00:00

  • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.

    abstract：:Adults with relapsed B cell acute lymphoblastic leukemia (B-ALL) have a dismal prognosis. Only those patients able to achieve a second remission with no minimal residual disease (MRD) have a hope for long-term survival in the context of a subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We ha...

    journal_title：Science translational medicine

    pub_type： 临床试验,杂志文章

    doi：10.1126/scitranslmed.3005930

    authors： Brentjens RJ,Davila ML,Riviere I,Park J,Wang X,Cowell LG,Bartido S,Stefanski J,Taylor C,Olszewska M,Borquez-Ojeda O,Qu J,Wasielewska T,He Q,Bernal Y,Rijo IV,Hedvat C,Kobos R,Curran K,Steinherz P,Jurcic J,Rosenbl

    更新日期：2013-03-20 00:00:00