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Fluid assessment in dialysis patients by point-of-care magnetic relaxometry.

Abstract：

:Magnetic resonance imaging (MRI) is a powerful diagnostic tool, but its use is restricted to the scanner suite. Here, we demonstrate that a bedside nuclear magnetic resonance (NMR) sensor can assess fluid status changes in individuals at a fraction of the time and cost compared to MRI. Our study recruited patients with end-stage renal disease (ESRD) who were regularly receiving hemodialysis treatments with intradialytic fluid removal as a model of volume overload and healthy controls as a model of euvolemia. Quantitative T2 measurements of the lower leg of patients with ESRD immediately before and after dialysis were compared to those of euvolemic healthy controls using both a 0.28-T bedside single-voxel NMR sensor and a 1.5-T clinical MRI scanner. In the MRI data, we found that the first sign of fluid overload was an expanded muscle extracellular fluid (ECF) space, a finding undetectable at this stage using physical exam. A decrease in muscle ECF upon fluid removal was similarly detectable with both the bedside sensor and MRI. Bioimpedance measurements performed comparably to the bedside NMR sensor but were generally worse than MRI. These findings suggest that bedside NMR may be a useful method to identify fluid overload early in patients with ESRD and potentially other hypervolemic patient populations.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Colucci LA,Corapi KM,Li M,Parada XV,Allegretti AS,Lin HY,Ausiello DA,Rosen MS,Cima MJ

doi

10.1126/scitranslmed.aau1749

subject

Has Abstract

pub_date

2019-07-24 00:00:00

issue

502

eissn

1946-6234

issn

1946-6242

pii

11/502/eaau1749

journal_volume

11

pub_type

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