Abstract:
:The blood-borne lipid lysophosphatidic acid and its receptor contribute to fetal-onset hydrocephalus, a severe neurological disorder of newborns.
journal_name
Sci Transl Medjournal_title
Science translational medicineauthors
McAllister JPdoi
10.1126/scitranslmed.3003119subject
Has Abstractpub_date
2011-09-07 00:00:00pages
99fs4issue
99eissn
1946-6234issn
1946-6242pii
3/99/99fs4journal_volume
3pub_type
评论,杂志文章abstract::Medical devices and implants made of synthetic materials can induce an immune-mediated process when implanted in the body called the foreign body response, which results in formation of a fibrous capsule around the implant. To explore the immune and stromal connections underpinning the foreign body response, we analyz...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aax3799
更新日期:2020-04-15 00:00:00
abstract::Most cancer deaths arise from metastases as a result of circulating tumor cells (CTCs) spreading from the primary tumor to vital organs. Despite progress in cancer prognosis, the role of CTCs in early disease diagnosis is unclear because of the low sensitivity of CTC assays. We demonstrate the high sensitivity of the ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aat5857
更新日期:2019-06-12 00:00:00
abstract::Patient-derived xenografts (PDXs) and PDX-derived cells (PDCs) are useful in preclinical research. We performed a drug screening assay using PDCs and identified proteasome inhibitors as promising drugs for cholangiocarcinoma (CCA) treatment. Furthermore, we determined that phosphate and tensin homology deleted on chro...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aay0152
更新日期:2020-09-23 00:00:00
abstract::Cancer immunotherapy using antibodies that target immune checkpoints has delivered outstanding results. However, responses only occur in a subset of patients, and it is not fully understood what biological processes determine an effective outcome. This lack of understanding hinders the development of rational combinat...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aav7816
更新日期:2019-07-17 00:00:00
abstract::Resveratrol is widely promoted as a potential cancer chemopreventive agent, but a lack of information on the optimal dose prohibits rationally designed trials to assess efficacy. To challenge the assumption that "more is better," we compared the pharmacokinetics and activity of a dietary dose with an intake 200 times ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaa7619
更新日期:2015-07-29 00:00:00
abstract::Aspirin use reduces the risk of colorectal neoplasia, at least in part, through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2)-related pathways. Hydroxyprostaglandin dehydrogenase 15-(nicotinamide adenine dinucleotide) (15-PGDH, HPGD) is down-regulated in colorectal cancers and functions...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3008481
更新日期:2014-04-23 00:00:00
abstract::Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes severe and often fatal disease in pigs and humans. There are currently no vaccines or treatments approved for human use. Studies in small-animal models of NiV infection suggest that antibody therapy may be a promising treatment. However, most studies ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3008929
更新日期:2014-06-25 00:00:00
abstract::Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but mechanisms underlying variable efficacy of treatment are incompletely understood. Our examination of severe infantile onset human SMA tissues obtai...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.abb6871
更新日期:2021-01-27 00:00:00
abstract::The brain is emerging as an important regulator of systemic glucose metabolism. Accumulating data from animal and observational human studies suggest that striatal dopamine signaling plays a role in glucose regulation, but direct evidence in humans is currently lacking. We present a series of experiments supporting th...
journal_title:Science translational medicine
pub_type: 杂志文章,随机对照试验
doi:10.1126/scitranslmed.aar3752
更新日期:2018-05-23 00:00:00
abstract::A study in this issue of Science Translational Medicine provides fresh insight into the role of autophagy in cancer. Kon et al. show that a specific type of autophagy, called chaperone-mediated autophagy (CMA), is consistently elevated in tumors and is required for optimal tumor growth and metastasis. Selective inhibi...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.3003390
更新日期:2011-11-16 00:00:00
abstract::The mechanisms by which some HIV-infected subjects resist disease progression, whereas others progress rapidly, are incompletely understood. Viral and host genetic factors, such as nef deletions and major histocompatibility complex alleles, explain a portion of the observed variability. However, it has been difficult ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3003941
更新日期:2012-05-30 00:00:00
abstract::Rapid antimicrobial susceptibility testing (AST) is urgently needed for informing treatment decisions and preventing the spread of antimicrobial resistance resulting from the misuse and overuse of antibiotics. To date, no phenotypic AST exists that can be performed within a single patient visit (30 min) directly from ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aal3693
更新日期:2017-10-04 00:00:00
abstract::Variants in the leucine-rich repeat kinase-2 (LRRK2) gene are associated with Parkinson's disease, leprosy, and Crohn's disease, three disorders with inflammation as an important component. Because of its high expression in granulocytes and CD68-positive cells, LRRK2 may have a function in innate immunity. We tested t...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aas9292
更新日期:2019-09-25 00:00:00
abstract::The etiology of major depression remains unknown, but dysfunction of serotonergic signaling has long been implicated in the pathophysiology of this disorder. p11 is an S100 family member recently identified as a serotonin 1B [5-hydroxytryptamine 1B (5-HT(1B))] and serotonin 4 (5-HT(4)) receptor-binding protein. Mutant...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3001079
更新日期:2010-10-20 00:00:00
abstract::In populations that have not been selected for family history of disease, it is unclear how commonly pathogenic variants (PVs) in disease-associated genes for rare Mendelian conditions are found and how often they are associated with clinical features of these conditions. We conducted independent, prospective analyses...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aag2367
更新日期:2016-11-09 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. We screened 751 familial ALS patient whole-exome sequences and identified six mutations including p.D40G in the ANXA11 gene in 13 individuals. The p.D40G mutation was absent from 70,000 control whole-exome sequences. This mutation segregated wi...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aad9157
更新日期:2017-05-03 00:00:00
abstract::Therapeutic intravesical instillation of bacillus Calmette-Guérin (BCG) is effective at triggering inflammation and eliciting successful tumor immunity in patients with non-muscle invasive bladder cancer, with 50 to 70% clinical response. Therapeutic success relies on repeated instillations of live BCG administered as...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3003586
更新日期:2012-06-06 00:00:00
abstract::The AAA+ adenosine triphosphatase (ATPase) Thorase plays a critical role in controlling synaptic plasticity by regulating the expression of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Bidirectional sequencing of exons of ATAD1, the gene encoding Thorase, in a cohort of patients wit...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aah4985
更新日期:2017-12-13 00:00:00
abstract::Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease. Others ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aan3464
更新日期:2018-04-11 00:00:00
abstract::Pluripotent stem cells are a scalable source of pancreatic cells for transplantation into patients with diabetes. Here, we describe how the field is gaining momentum toward a β cell replacement therapy. ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aaa9359
更新日期:2015-12-02 00:00:00
abstract::With continued advances in science and technology, there is great potential to extend our healthspan as we age. ...
journal_title:Science translational medicine
pub_type: 社论
doi:10.1126/scitranslmed.abd3816
更新日期:2020-10-21 00:00:00
abstract::Canavan disease is a hereditary leukodystrophy caused by mutations in the aspartoacylase gene (ASPA), leading to loss of enzyme activity and increased concentrations of the substrate N-acetyl-aspartate (NAA) in the brain. Accumulation of NAA results in spongiform degeneration of white matter and severe impairment of p...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3003454
更新日期:2012-12-19 00:00:00
abstract::Overcoming drug resistance and targeting leukemic stem cells (LSCs) remain major challenges in curing BCR-ABL+ human leukemia. Using an advanced drug/proliferation screen, we have uncovered a prosurvival role for protein phosphatase 2A (PP2A) in tyrosine kinase inhibitor (TKI)-insensitive leukemic cells, regulated by ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aan8735
更新日期:2018-02-07 00:00:00
abstract::A skin-penetrant small molecule activates melanin production to protect cells from cancer-inducing ultraviolet damage. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aan8202
更新日期:2017-07-05 00:00:00
abstract::Despite the remarkable enhancements in breast cancer classification and characterization, an exhaustive comprehension of the underlying carcinogenic processes and an accurate prediction of its clinical behavior are yet to be achieved. On the wave of recent scientific advances and clinical findings, new cutting-edge te...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3001329
更新日期:2010-09-01 00:00:00
abstract::Three-dimensional (3D) titanium-mesh scaffolds offer many advantages over autologous bone grafting for the regeneration of challenging large segmental bone defects. Our study supports the hypothesis that endogenous bone defect regeneration can be promoted by mechanobiologically optimized Ti-mesh scaffolds. Using finit...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aam8828
更新日期:2018-01-10 00:00:00
abstract::Next-generation sequencing technologies have greatly expanded our understanding of cancer genetics. Antisense technology is an attractive platform with the potential to translate these advances into improved cancer therapeutics, because antisense oligonucleotide (ASO) inhibitors can be designed on the basis of gene se...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.aac5272
更新日期:2015-11-18 00:00:00
abstract::Increased iron in cancer cells drives selective sensitization of tumors to ascorbate treatment to prolong survival. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.aan2778
更新日期:2017-04-12 00:00:00
abstract::Osteoarthritis (OA) is a common degenerative condition that afflicts more than 70% of the population between 55 and 77 years of age. Although its prevalence is rising globally with aging of the population, current therapy is limited to symptomatic relief and, in severe cases, joint replacement surgery. We report that ...
journal_title:Science translational medicine
pub_type: 杂志文章
doi:10.1126/scitranslmed.3005409
更新日期:2013-03-13 00:00:00
abstract::MG53 promotes sarcolemmal repair in the mdx mouse model of Duchenne muscular dystrophy (Weisleder et al., this issue) and identifies a new protein therapeutic for muscle disease. ...
journal_title:Science translational medicine
pub_type: 评论,杂志文章
doi:10.1126/scitranslmed.3004082
更新日期:2012-06-20 00:00:00