当前位置： SCI文献检索 > Science Translational Medicine期刊下所有文献 > Patients with autism spectrum disorders display reproducible functional connectivity alterations.

Patients with autism spectrum disorders display reproducible functional connectivity alterations.

Abstract：

:Despite the high clinical burden, little is known about pathophysiology underlying autism spectrum disorder (ASD). Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have found atypical synchronization of brain activity in ASD. However, no consensus has been reached on the nature and clinical relevance of these alterations. Here, we addressed these questions in four large ASD cohorts. Using rs-fMRI, we identified functional connectivity alterations associated with ASD. We tested for associations of these imaging phenotypes with clinical and demographic factors such as age, sex, medication status, and clinical symptom severity. Our results showed reproducible patterns of ASD-associated functional hyper- and hypoconnectivity. Hypoconnectivity was primarily restricted to sensory-motor regions, whereas hyperconnectivity hubs were predominately located in prefrontal and parietal cortices. Shifts in cortico-cortical between-network connectivity from outside to within the identified regions were shown to be a key driver of these abnormalities. This reproducible pathophysiological phenotype was partially associated with core ASD symptoms related to communication and daily living skills and was not affected by age, sex, or medication status. Although the large effect sizes in standardized cohorts are encouraging with respect to potential application as a treatment and for patient stratification, the moderate link to clinical symptoms and the large overlap with healthy controls currently limit the usability of identified alterations as diagnostic or efficacy readout.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Holiga Š,Hipp JF,Chatham CH,Garces P,Spooren W,D'Ardhuy XL,Bertolino A,Bouquet C,Buitelaar JK,Bours C,Rausch A,Oldehinkel M,Bouvard M,Amestoy A,Caralp M,Gueguen S,Ly-Le Moal M,Houenou J,Beckmann CF,Loth E,Murphy D

doi

10.1126/scitranslmed.aat9223

subject

Has Abstract

pub_date

2019-02-27 00:00:00

issue

481

eissn

1946-6234

issn

1946-6242

pii

11/481/eaat9223

journal_volume

11

pub_type

杂志文章

相关文献

Science Translational Medicine文献大全
  • Exosomes derived from Vδ2-T cells control Epstein-Barr virus-associated tumors and induce T cell antitumor immunity.

    abstract：:Treatment of life-threatening Epstein-Barr virus (EBV)-associated tumors remains a great challenge, especially for patients with relapsed or refractory disease. Here, we found that exosomes derived from phosphoantigen-expanded Vδ2-T cells (Vδ2-T-Exos) contained death-inducing ligands (FasL and TRAIL), an activating re...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaz3426

    authors： Wang X,Xiang Z,Liu Y,Huang C,Pei Y,Wang X,Zhi H,Wong WH,Wei H,Ng IO,Lee PP,Chan GC,Lau YL,Tu W

    更新日期：2020-09-30 00:00:00

  • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.

    abstract：:Adults with relapsed B cell acute lymphoblastic leukemia (B-ALL) have a dismal prognosis. Only those patients able to achieve a second remission with no minimal residual disease (MRD) have a hope for long-term survival in the context of a subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We ha...

    journal_title：Science translational medicine

    pub_type： 临床试验,杂志文章

    doi：10.1126/scitranslmed.3005930

    authors： Brentjens RJ,Davila ML,Riviere I,Park J,Wang X,Cowell LG,Bartido S,Stefanski J,Taylor C,Olszewska M,Borquez-Ojeda O,Qu J,Wasielewska T,He Q,Bernal Y,Rijo IV,Hedvat C,Kobos R,Curran K,Steinherz P,Jurcic J,Rosenbl

    更新日期：2013-03-20 00:00:00

  • Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers.

    abstract：:Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40 in the central nervous system (CNS)...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3005615

    authors： Potter R,Patterson BW,Elbert DL,Ovod V,Kasten T,Sigurdson W,Mawuenyega K,Blazey T,Goate A,Chott R,Yarasheski KE,Holtzman DM,Morris JC,Benzinger TL,Bateman RJ

    更新日期：2013-06-12 00:00:00

  • Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA.

    abstract：:Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but mechanisms underlying variable efficacy of treatment are incompletely understood. Our examination of severe infantile onset human SMA tissues obtai...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.abb6871

    authors： Kong L,Valdivia DO,Simon CM,Hassinan CW,Delestrée N,Ramos DM,Park JH,Pilato CM,Xu X,Crowder M,Grzyb CC,King ZA,Petrillo M,Swoboda KJ,Davis C,Lutz CM,Stephan AH,Zhao X,Weetall M,Naryshkin NA,Crawford TO,Mentis GZ

    更新日期：2021-01-27 00:00:00

  • Parallel discovery of Alzheimer's therapeutics.

    abstract：:As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid deposition. This effort has resulted in slow progress and disappointing ou...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3008228

    authors： Lo AW,Ho C,Cummings J,Kosik KS

    更新日期：2014-06-18 00:00:00

  • A "datathon" model to support cross-disciplinary collaboration.

    abstract：:In recent years, there has been a growing focus on the unreliability of published biomedical and clinical research. To introduce effective new scientific contributors to the culture of health care, we propose a "datathon" or "hackathon" model in which participants with disparate, but potentially synergistic and comple...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aad9072

    authors： Aboab J,Celi LA,Charlton P,Feng M,Ghassemi M,Marshall DC,Mayaud L,Naumann T,McCague N,Paik KE,Pollard TJ,Resche-Rigon M,Salciccioli JD,Stone DJ

    更新日期：2016-04-06 00:00:00

  • Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing.

    abstract：:Fibroblasts are primary cellular protagonists of wound healing. They also exhibit circadian timekeeping, which imparts an approximately 24-hour rhythm to their biological function. We interrogated the functional consequences of the cell-autonomous clockwork in fibroblasts using a proteome-wide screen for rhythmically ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aal2774

    authors： Hoyle NP,Seinkmane E,Putker M,Feeney KA,Krogager TP,Chesham JE,Bray LK,Thomas JM,Dunn K,Blaikley J,O'Neill JS

    更新日期：2017-11-08 00:00:00

  • An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs.

    abstract：:Clinical advancement of the bioartificial liver is hampered by the lack of expandable human hepatocytes and appropriate bioreactors and carriers to encourage hepatic cells to function during extracorporeal circulation. We have recently developed an efficient approach for derivation of expandable liver progenitor-like ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aba5146

    authors： Li WJ,Zhu XJ,Yuan TJ,Wang ZY,Bian ZQ,Jing HS,Shi X,Chen CY,Fu GB,Huang WJ,Shi YP,Liu Q,Zeng M,Zhang HD,Wu HP,Yu WF,Zhai B,Yan HX

    更新日期：2020-07-08 00:00:00

  • Local iontophoretic administration of cytotoxic therapies to solid tumors.

    abstract：:Parenteral and oral routes have been the traditional methods of administering cytotoxic agents to cancer patients. Unfortunately, the maximum potential effect of these cytotoxic agents has been limited because of systemic toxicity and poor tumor perfusion. In an attempt to improve the efficacy of cytotoxic agents whil...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3009951

    authors： Byrne JD,Jajja MR,O'Neill AT,Bickford LR,Keeler AW,Hyder N,Wagner K,Deal A,Little RE,Moffitt RA,Stack C,Nelson M,Brooks CR,Lee W,Luft JC,Napier ME,Darr D,Anders CK,Stack R,Tepper JE,Wang AZ,Zamboni WC,Yeh JJ,

    更新日期：2015-02-04 00:00:00

  • Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).

    abstract：:Aspirin use reduces the risk of colorectal neoplasia, at least in part, through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2)-related pathways. Hydroxyprostaglandin dehydrogenase 15-(nicotinamide adenine dinucleotide) (15-PGDH, HPGD) is down-regulated in colorectal cancers and functions...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3008481

    authors： Fink SP,Yamauchi M,Nishihara R,Jung S,Kuchiba A,Wu K,Cho E,Giovannucci E,Fuchs CS,Ogino S,Markowitz SD,Chan AT

    更新日期：2014-04-23 00:00:00

  • Liberating health data for clinical research applications.

    abstract：:Global investments in health information technology (HIT) in the form of electronic health record systems represent important new strategies to improve the quality and efficiency of health care. These potential benefits of HIT will not be achieved without direct attention to the use of health care information for clin...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3000764

    authors： Nadler JJ,Downing GJ

    更新日期：2010-02-10 00:00:00

  • Using health information technology to engage communities in health, education, and research.

    abstract：:The August 2011 Clinical and Translational Science Awards conference "Using IT to Improve Community Health: How Health Care Reform Supports Innovation" convened four "Think Tank" sessions. Thirty individuals, representing various perspectives on community engagement, attended the "Health information technology (HIT) a...

    journal_title：Science translational medicine

    pub_type：

    doi：10.1126/scitranslmed.3003363

    authors： Marriott LK,Nelson DA,Allen S,Calhoun K,Eldredge CE,Kimminau KS,Lucero RJ,Pineda-Reyes F,Rumala BB,Varanasi AP,Wasser JS,Shannon J

    更新日期：2012-02-01 00:00:00

  • PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.

    abstract：:PTEN (phosphatase and tensin homolog) loss of function is the most common genetic aberration in endometrioid endometrial carcinomas. In addition to its well-described role in cell signaling, PTEN is involved in the maintenance of genomic stability. Loss of PTEN function causes defects in repair of DNA double-strand br...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001538

    authors： Dedes KJ,Wetterskog D,Mendes-Pereira AM,Natrajan R,Lambros MB,Geyer FC,Vatcheva R,Savage K,Mackay A,Lord CJ,Ashworth A,Reis-Filho JS

    更新日期：2010-10-13 00:00:00

  • Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

    abstract：:SORLA/SORL1 is a unique neuronal sorting receptor for the amyloid precursor protein that has been causally implicated in both sporadic and autosomal dominant familial forms of Alzheimer's disease (AD). Brain concentrations of SORLA are inversely correlated with amyloid-β (Aβ) in mouse models and AD patients, suggestin...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3007747

    authors： Caglayan S,Takagi-Niidome S,Liao F,Carlo AS,Schmidt V,Burgert T,Kitago Y,Füchtbauer EM,Füchtbauer A,Holtzman DM,Takagi J,Willnow TE

    更新日期：2014-02-12 00:00:00

  • Emerging viral diseases: confronting threats with new technologies.

    abstract：:Emerging viral diseases pose ongoing health threats, particularly in an era of globalization; however, new biomedical research technologies such as genome sequencing and structure-based vaccine and drug design have improved our ability to respond to viral threats. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3009872

    authors： Marston HD,Folkers GK,Morens DM,Fauci AS

    更新日期：2014-09-10 00:00:00

  • CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors.

    abstract：:Tumor cells engineered to express therapeutic agents have shown promise to treat cancer. However, their potential to target cell surface receptors specific to the tumor site and their posttreatment fate have not been explored. We created therapeutic tumor cells expressing ligands specific to primary and recurrent tumo...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aao3240

    authors： Reinshagen C,Bhere D,Choi SH,Hutten S,Nesterenko I,Wakimoto H,Le Roux E,Rizvi A,Du W,Minicucci C,Shah K

    更新日期：2018-07-11 00:00:00

  • Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis.

    abstract：:Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on intralesional drug biodistribution in infected tissues has limited pharmacokinetic (PK) modeling efforts to optimize TBM treatments. Curr...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aau0965

    authors： Tucker EW,Guglieri-Lopez B,Ordonez AA,Ritchie B,Klunk MH,Sharma R,Chang YS,Sanchez-Bautista J,Frey S,Lodge MA,Rowe SP,Holt DP,Gobburu JVS,Peloquin CA,Mathews WB,Dannals RF,Pardo CA,Kannan S,Ivaturi VD,Jain SK

    更新日期：2018-12-05 00:00:00

  • Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.

    abstract：:Lung cancer is more deadly than colon, breast, and prostate cancers combined, and treatment improvements have failed to improve prognosis significantly. Here, we identify a critical mediator of lung cancer progression, Rac1b, a tumor-associated protein with cell-transforming properties that are linked to the matrix me...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3004062

    authors： Stallings-Mann ML,Waldmann J,Zhang Y,Miller E,Gauthier ML,Visscher DW,Downey GP,Radisky ES,Fields AP,Radisky DC

    更新日期：2012-07-11 00:00:00

  • Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.

    abstract：:Biallelic mutations in ABCC6 cause pseudoxanthoma elasticum (PXE), a disease characterized by calcification in the skin, eyes, and blood vessels. The function of ATP-binding cassette C6 (ABCC6) and the pathogenesis of PXE remain unclear. We used mouse models and patient fibroblasts to demonstrate genetic interaction a...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aal1669

    authors： Ziegler SG,Ferreira CR,MacFarlane EG,Riddle RC,Tomlinson RE,Chew EY,Martin L,Ma CT,Sergienko E,Pinkerton AB,Millán JL,Gahl WA,Dietz HC

    更新日期：2017-06-07 00:00:00

  • How to handle an industry in disruption: Intervene or laissez-faire?

    abstract：:An analysis of four regions in four countries suggests that the best way to mitigate disruption of the pharmaceutical industry is not to ignore or stem it but to sponsor initiatives that keep scientists engaged. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aaa3679

    authors： Munos B

    更新日期：2015-05-06 00:00:00

  • Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β.

    abstract：:Cancer-associated thrombocytosis and high concentrations of circulating transforming growth factor-β1 (TGF-β1) are frequently observed in patients with progressive cancers. Using genetic and pharmacological approaches, we show a direct link between thrombin catalytic activity and release of mature TGF-β1 from platelet...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aay4860

    authors： Metelli A,Wu BX,Riesenberg B,Guglietta S,Huck JD,Mills C,Li A,Rachidi S,Krieg C,Rubinstein MP,Gewirth DT,Sun S,Lilly MB,Wahlquist AH,Carbone DP,Yang Y,Liu B,Li Z

    更新日期：2020-01-08 00:00:00

  • A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.

    abstract：:Misuse of prescription opioids, opioid addiction, and overdose underscore the urgent need for developing addiction-free effective medications for treating severe pain. Mu opioid peptide (MOP) receptor agonists provide very effective pain relief. However, severe side effects limit their use in the clinical setting. Ago...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aar3483

    authors： Ding H,Kiguchi N,Yasuda D,Daga PR,Polgar WE,Lu JJ,Czoty PW,Kishioka S,Zaveri NT,Ko MC

    更新日期：2018-08-29 00:00:00

  • AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.

    abstract：:Next-generation sequencing technologies have greatly expanded our understanding of cancer genetics. Antisense technology is an attractive platform with the potential to translate these advances into improved cancer therapeutics, because antisense oligonucleotide (ASO) inhibitors can be designed on the basis of gene se...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aac5272

    authors： Hong D,Kurzrock R,Kim Y,Woessner R,Younes A,Nemunaitis J,Fowler N,Zhou T,Schmidt J,Jo M,Lee SJ,Yamashita M,Hughes SG,Fayad L,Piha-Paul S,Nadella MV,Mohseni M,Lawson D,Reimer C,Blakey DC,Xiao X,Hsu J,Revenko A

    更新日期：2015-11-18 00:00:00

  • Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

    abstract：:About 25% of high-grade cervical intraepithelial neoplasias (CIN2/3) caused by human papillomavirus serotype 16 (HPV16) undergo complete spontaneous regression. However, to date, therapeutic vaccination strategies for HPV disease have yielded limited success when measured by their ability to induce robust peripheral b...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3007323

    authors： Maldonado L,Teague JE,Morrow MP,Jotova I,Wu TC,Wang C,Desmarais C,Boyer JD,Tycko B,Robins HS,Clark RA,Trimble CL

    更新日期：2014-01-29 00:00:00

  • SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment.

    abstract：:The mechanisms by which some HIV-infected subjects resist disease progression, whereas others progress rapidly, are incompletely understood. Viral and host genetic factors, such as nef deletions and major histocompatibility complex alleles, explain a portion of the observed variability. However, it has been difficult ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3003941

    authors： Hartigan-O'Connor DJ,Abel K,Van Rompay KK,Kanwar B,McCune JM

    更新日期：2012-05-30 00:00:00

  • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.

    abstract：:Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T cell activation. Although evidence for an active immune response, including infiltration with CD8(+) T cells, can be found in a subset of patients, those tumors are nonetheless not immunologically rejecte...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3006504

    authors： Spranger S,Spaapen RM,Zha Y,Williams J,Meng Y,Ha TT,Gajewski TF

    更新日期：2013-08-28 00:00:00

  • The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

    abstract：:Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease. Others ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aan3464

    authors： Krall JA,Reinhardt F,Mercury OA,Pattabiraman DR,Brooks MW,Dougan M,Lambert AW,Bierie B,Ploegh HL,Dougan SK,Weinberg RA

    更新日期：2018-04-11 00:00:00

  • Rapid pathogen-specific phenotypic antibiotic susceptibility testing using digital LAMP quantification in clinical samples.

    abstract：:Rapid antimicrobial susceptibility testing (AST) is urgently needed for informing treatment decisions and preventing the spread of antimicrobial resistance resulting from the misuse and overuse of antibiotics. To date, no phenotypic AST exists that can be performed within a single patient visit (30 min) directly from ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aal3693

    authors： Schoepp NG,Schlappi TS,Curtis MS,Butkovich SS,Miller S,Humphries RM,Ismagilov RF

    更新日期：2017-10-04 00:00:00

  • Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson's disease.

    abstract：:Inhaled drugs offer advantages, such as rapid onset of action, but require formulations and delivery systems that reproducibly and conveniently administer the drug. CVT-301 is a powder formulation of levodopa delivered by a breath-actuated inhaler that has been developed for treating OFF episodes (motor fluctuations b...

    journal_title：Science translational medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1126/scitranslmed.aad8858

    authors： Lipp MM,Batycky R,Moore J,Leinonen M,Freed MI

    更新日期：2016-10-12 00:00:00

  • Immune-mediated pathology in Duchenne muscular dystrophy.

    abstract：:Immunological and inflammatory processes downstream of dystrophin deficiency as well as metabolic abnormalities, defective autophagy, and loss of regenerative capacity all contribute to muscle pathology in Duchenne muscular dystrophy (DMD). These downstream cascades offer potential avenues for pharmacological interven...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aaa7322

    authors： Rosenberg AS,Puig M,Nagaraju K,Hoffman EP,Villalta SA,Rao VA,Wakefield LM,Woodcock J

    更新日期：2015-08-05 00:00:00