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Parallel discovery of Alzheimer's therapeutics.

Abstract：

:As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid deposition. This effort has resulted in slow progress and disappointing outcomes. Here, we describe a "portfolio approach" in which multiple distinct drug development projects are undertaken simultaneously. Although a greater upfront investment is required, the probability of at least one success should be higher with "multiple shots on goal," increasing the efficiency of this undertaking. However, our portfolio simulations show that the risk-adjusted return on investment of parallel discovery is insufficient to attract private-sector funding. Nevertheless, the future cost savings of an effective AD therapy to Medicare and Medicaid far exceed this investment, suggesting that government funding is both essential and financially beneficial.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Lo AW,Ho C,Cummings J,Kosik KS

doi

10.1126/scitranslmed.3008228

subject

Has Abstract

pub_date

2014-06-18 00:00:00

pages

241cm5

issue

241

eissn

1946-6234

issn

1946-6242

pii

6/241/241cm5

journal_volume

6

pub_type

杂志文章

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