Abstract:
:Immunological and inflammatory processes downstream of dystrophin deficiency as well as metabolic abnormalities, defective autophagy, and loss of regenerative capacity all contribute to muscle pathology in Duchenne muscular dystrophy (DMD). These downstream cascades offer potential avenues for pharmacological intervention. Modulating the inflammatory response and inducing immunological tolerance to de novo dystrophin expression will be critical to the success of dystrophin-replacement therapies. This Review focuses on the role of the inflammatory response in DMD pathogenesis and opportunities for clinical intervention.
journal_name
Sci Transl Medjournal_title
Science translational medicineauthors
Rosenberg AS,Puig M,Nagaraju K,Hoffman EP,Villalta SA,Rao VA,Wakefield LM,Woodcock Jdoi
10.1126/scitranslmed.aaa7322subject
Has Abstractpub_date
2015-08-05 00:00:00pages
299rv4issue
299eissn
1946-6234issn
1946-6242pii
7/299/299rv4journal_volume
7pub_type
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