Abstract:
:Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors, such as cholesterol crystals in atherosclerosis, or hyperglycemia, ceramides, and islet amyloid polypeptide in type 2 diabetes. Therapeutics that target IL-1β in clinical trials for type 2 diabetes might also decrease the incidence of atherosclerosis.
journal_name
Sci Transl Medjournal_title
Science translational medicineauthors
Masters SL,Latz E,O'Neill LAdoi
10.1126/scitranslmed.3001902subject
Has Abstractpub_date
2011-05-04 00:00:00pages
81ps17issue
81eissn
1946-6234issn
1946-6242pii
3/81/81ps17journal_volume
3pub_type
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