Abstract：
:Dyslexia is a learning disability characterized by difficulty learning to read and write. The underlying biological and genetic etiology remains poorly understood. One candidate gene, dyslexia susceptibility 1 candidate 1 (DYX1C1), has been shown to be associated with deficits in short-term memory in dyslexic populations. The purpose of the current study was to examine the behavioral phenotype of a mouse model with a homozygous conditional (forebrain) knockout of the rodent homolog Dyx1c1. Twelve Dyx1c1 conditional homozygous knockouts, 7 Dyx1c1 conditional heterozygous knockouts and 6 wild-type controls were behaviorally assessed. Mice with the homozygous Dyx1c1 knockout showed deficits on memory and learning, but not on auditory or motor tasks. These findings affirm existing evidence that DYX1C1 may play an underlying role in the development of neural systems important to learning and memory, and disruption of this function could contribute to the learning deficits seen in individuals with dyslexia.
journal_name
Brain Langjournal_title
Brain and languageauthors
Rendall AR,Tarkar A,Contreras-Mora HM,LoTurco JJ,Fitch RHdoi
10.1016/j.bandl.2015.04.008subject
Has Abstractpub_date
2017-09-01 00:00:00pages
30-38eissn
0093-934Xissn
1090-2155pii
S0093-934X(15)00102-9journal_volume
172pub_type
杂志文章abstract：:Previous studies have identified several brain regions that appear to be involved in the acquisition of novel word forms. Standard word-by-word presentation is often used although exposure to a new language normally occurs in a natural, real world situation. In the current experiment we investigated naturalistic langu...
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journal_title：Brain and language
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journal_title：Brain and language
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pub_type： 杂志文章
doi：10.1016/j.bandl.2016.06.007
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journal_title：Brain and language
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2006.05.004
更新日期：2006-08-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2017.03.001
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2011.09.009
更新日期：2012-05-01 00:00:00
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journal_title：Brain and language
pub_type： 临床试验,杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(87)90071-x
更新日期：1987-07-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(88)90129-0
更新日期：1988-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0093-934x(02)00519-9
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2009.08.004
更新日期：2009-11-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2019.05.002
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journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1016/j.bandl.2006.05.006
更新日期：2006-09-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2011.08.003
更新日期：2012-01-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2001.2515
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2004.12.004
更新日期：2005-08-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(87)90119-2
更新日期：1987-09-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2018.09.002
更新日期：2018-11-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章,meta分析
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