当前位置： SCI文献检索 > JOURNAL OF INTERVENTIONAL CARDIOLOGY期刊下所有文献 > Randomized comparison of balloon aortic valvuloplasty performed with or without rapid cardiac pacing: The pacing versus no pacing (PNP) study.

Randomized comparison of balloon aortic valvuloplasty performed with or without rapid cardiac pacing: The pacing versus no pacing (PNP) study.

Abstract：

OBJECTIVES:To compare the effectiveness and safety of balloon aortic valvuloplasty (BAV) performed with or without rapid ventricular pacing (RP). BACKGROUND:BAV technique is poorly standardized. METHODS:One hundred consecutive patients were randomly assigned 1:1 between BAV performed with or without RP. Exclusion criteria were an immediate indication for surgical or transcatheter aortic valve replacement, presentation in cardiogenic shock or pulmonary edema refractory to medical stabilization. RESULTS:There were 51 patients in the BAV group performed with RP, 49 in the BAV group without RP (noRP). Procedural success (50% hemodynamic gradient reduction) was achieved in 37.3% and 55.1%, respectively (P = 0.16). Fewer people in the noRP group complained of poor tolerance to the procedure (16% vs 41%). The primary efficacy endpoint, a 50% reduction in the mean echocardiographic trans-aortic gradient, was met in 21/49 patients in the noRP group compared to 20/51 in the RP (42.9% vs 39.2%; P = 0.84). No significant difference between the groups was observed in the primary safety endpoint, a 30-day composite of death, myocardial infarction, stroke, acute aortic regurgitation, and BARC bleeding ≥3 (8.2% noRP vs 13.7%; P = 0.53). The noRP group required fewer bailout temporary pacemakers (P = 0.048) and had a lower incidence of moderate/severe renal function worsening (4.1% vs 17.6%; P = 0.052). CONCLUSIONS:Rapid ventricular pacing did not influence BAV efficacy or safety and tolerance was slightly worse.

journal_name

J Interv Cardiol

journal_title

Journal of interventional cardiology

authors

Dall'Ara G,Marzocchi A,Taglieri N,Moretti C,Rodinò G,Chiarabelli M,Bottoni P,Marrozzini C,Sabattini MR,Bacchi-Reggiani ML,Rapezzi C,Saia F

doi

10.1111/joic.12452

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

51-59

issue

1

eissn

0896-4327

issn

1540-8183

journal_volume

31

pub_type

杂志文章,随机对照试验

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