Management of Preinvasive Lesions.

Abstract:

:Serous tubal intraepithelial carcinoma is considered the precursor lesion of high-grade serous carcinoma, and found in both low-risk and high-risk populations. Isolated serous tubal intraepithelial carcinomas in patients with BRCA1/2 mutations are detected in ∼2% of patients undergoing risk-reducing bilateral salpingo-oophorectomy and even with removal of the tubes and ovaries the rate of developing primary peritoneal carcinoma following remains up to 7.5%. Postoperative recommendations after finding incidental STICs remain unclear and surgical staging, adjuvant chemotherapy, or observation have been proposed. Discovery of STIC should prompt consideration of hereditary cancer program referral for BRCA1/2 mutation screening.

journal_name

Clin Obstet Gynecol

authors

Patrono MG,Corzo C,Iniesta M,Ramirez PT

doi

10.1097/GRF.0000000000000316

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

771-779

issue

4

eissn

0009-9201

issn

1532-5520

journal_volume

60

pub_type

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