Abstract:
OBJECTIVE:To evaluate frequency distribution of adenosine deaminase 1 (ADA1) G22 A alleles and genotypes in fertile and infertile men. METHODS:In this study we evaluate frequency distribution of ADA1 G22 A alleles and genotypes in 200 fertile and 200 infertile men. The polymerase chain reaction-restriction fragment length polymorphism technique was used for determining ADA1 G22 A variants. In addition, ADA isoenzymes activities (ADA1 and ADA2) were measured using colorimetric method. RESULTS:The frequency of GG genotype was significantly higher and GA genotype was lower in infertile males compared with fertile men (P = .048 and P = .045, respectively). However, there was not any noticeable difference in allele distribution between groups (P >.05). Based on logistic regression analysis, the GA genotype has a protective role and can decrease the risk of male infertility 1.7 times (P = .046). There were significantly higher activities of ADAT and its isoenzymes in infertile males compared with fertile men (P <.05). Also, the ADA1 activity with GG genotype was higher than GA carriers in all population (P = .001). CONCLUSION:Our results revealed that the activity of ADA isoenzymes and distribution of ADA1 G22 A genotypes were different among fertile and infertile men and more likely the GA genotype, which had lower ADA1 activity and was higher in fertile men is a protective factor against infertility.
journal_name
Urologyjournal_title
Urologyauthors
Fattahi A,Khodadadi I,Amiri I,Latifi Z,Ghorbani M,Tavilani Hdoi
10.1016/j.urology.2015.06.034subject
Has Abstractpub_date
2015-10-01 00:00:00pages
730-4issue
4eissn
0090-4295issn
1527-9995pii
S0090-4295(15)00631-7journal_volume
86pub_type
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