Abstract:
:The respiratory diseases caused by rhinovirus, respiratory syncytial virus, and influenza virus represent a large social and financial burden on healthcare worldwide. Although all three viruses have distinctly unique properties in terms of infection and replication, they share the ability to exploit/manipulate the host-cell nucleocytoplasmic transport system in order to replicate effectively and efficiently. This review outlines the various ways in which infection by these viruses impacts on the host nucleocytoplasmic transport system, and examples where inhibition thereof in turn decreases viral replication. The highly conserved nature of the nucleocytoplasmic transport system and the viral proteins that interact with it make this virus-host interface a prime candidate for the development of specific antiviral therapeutics in the future.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Caly L,Ghildyal R,Jans DAdoi
10.3389/fmicb.2015.00848subject
Has Abstractpub_date
2015-08-14 00:00:00pages
848issn
1664-302Xjournal_volume
6pub_type
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abstract::[This corrects the article DOI: 10.3389/fmicb.2019.00780.]. ...
journal_title:Frontiers in microbiology
pub_type: 已发布勘误
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