Abstract：
:Five issues are discussed with respect to the diagnosis, etiology, treatment, prognosis, and pathogenesis of neonatal seizures. The presentation of a newborn with seizures represents a true emergency and frequently indicates significant neurologic dysfunction or damage to the immature nervous system. Despite the urgency to establish a diagnosis, several unique aspects of neonatal seizures impede prompt recognition. In addition, several etiologic possibilities may be associated with seizures. The efficacy of antiepileptic drugs and the prediction of outcome of patients with neonatal seizures are controversial. Experimental research in developing animals suggests both a selective vulnerability and resistance of the brains of immature animals subjected to neonatal seizures.
journal_name
Pediatr Clin North Amjournal_title
Pediatric clinics of North Americaauthors
Scher MS,Painter MJdoi
10.1016/s0031-3955(16)36650-0subject
Has Abstractpub_date
1989-04-01 00:00:00pages
281-310issue
2eissn
0031-3955issn
1557-8240pii
S0031-3955(16)36650-0journal_volume
36pub_type
杂志文章,评审abstract：:Recently, great progress has been made in the development of vaccines against Hib. Four polysaccharide-protein conjugate vaccines are actively being tested. Three of these (PRP-D, HbOC, and PRP-OMP) are currently licensed for use in children at 15-18 months of age. Clinical trials of these vaccines in infants are curr...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)36905-x
更新日期：1990-06-01 00:00:00
abstract：:Although breastfeeding is well accepted as the optimal method of infant feeding, the US failed to reach the goals set for the year 2000. Support from employers, health insurers, health providers, and society are required to reach the goals set forth in Healthy People 2010-75% of mothers initiate breastfeeding, 50% of ...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章
doi：10.1016/s0031-3955(05)70298-4
更新日期：2001-02-01 00:00:00
abstract：:This article discusses various anomalies and abnormalities of the umbilical cord and issues related to cord care. The issue of screening newborns with an isolated single umbilical artery for renal abnormalities is addressed. The clinical presentation of infants with omphalomesenteric and urachal duct remants along wit...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2004.01.010
更新日期：2004-06-01 00:00:00
abstract：:Auricular reconstruction of microtia is available and is extremely satisfying for the patient, family, and care givers. The patient can look forward to a realistic pinna. With current research activity, auricular reconstruction could evolve even further. The pediatrician is an extremely important member of this effort...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(05)70516-2
更新日期：1996-12-01 00:00:00
abstract：:The diagnosis of a parasitic infection depends upon demonstration of the organism in stool, blood, or tissue specimens, and a variety of relatively simple procedures is available for this purpose. In this article, the author describes those procedures that are most frequently used on a routine basis. ...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章
doi：10.1016/s0031-3955(16)34868-4
更新日期：1985-08-01 00:00:00
abstract：:Overdose of a tricyclic antidepressant is a serious and all-too-frequent occurrence. The diagnosis must be considered in known or suspected overdoses, and signs such as a dry axilla, tachycardia, and wide QRS must be specifically sought. Management depends upon support of vital functions and a thorough understanding o...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)35002-7
更新日期：1986-04-01 00:00:00
abstract：:Lymphocytic interstitial pneumonia is at present a pathologic diagnosis. In the setting of a chronic interstitial pneumonia in a child with lymphocytosis, hyperglobulinemia, and lymphadenopathy or parotid enlargement, the diagnosis is often clinically presumed. At present the diagnosis can be established firmly only b...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)38044-0
更新日期：1991-02-01 00:00:00
abstract：:ADHD is a highly prevalent condition with the core symptoms of functionally impairing limitations in sustained attention and impulsivity/overactivity. Other frequent symptoms include overemotionality or overreactivity, academic underachievement, low self-esteem, and interpersonal difficulties. The assessment for and d...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(05)70157-7
更新日期：1999-10-01 00:00:00
abstract：:Retinoblastoma is the most common neoplasm of the eye in childhood, and represents 3% of all childhood malignancies. Retinoblastoma is a cancer of the very young; two-thirds are diagnosed before 2 years of age and 95% before 5 years. Retinoblastoma presents in 2 distinct clinical forms: (1) a bilateral or multifocal, ...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2014.09.014
更新日期：2015-02-01 00:00:00
abstract：:Sleep problems are common in many pediatric medical disorders and complicate management and patient outcomes. A wide range of conditions, including asthma, cystic fibrosis, sickle cell disease, gastroesophageal reflux, neuromuscular diseases, scoliosis, craniofacial abnormalities, obesity, and chromosomal disorders, h...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(03)00185-8
更新日期：2004-02-01 00:00:00
abstract：:Headache is a common chronic and recurrent symptom in children and adolescents. The author discusses the prevalence of headache, its differential diagnosis, interpretation of symptoms, methods of assessment, and pharmacologic and nonpharmacologic treatment approaches. ...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)34683-1
更新日期：1984-10-01 00:00:00
abstract：:Neonatal anemia is a condition with a diverse etiologic spectrum.Therefore, in order to form a focused differential diagnosis, it is important for the caregiver to have some knowledge of the more common causes of low hemoglobin and hematocrit concentrations in the neonate. Proper history taking, physical examination, ...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2004.03.006
更新日期：2004-08-01 00:00:00
abstract：:Fractures are common during childhood; however, they can also be the presenting symptom of primary or secondary causes of bone fragility. The challenge is to identify those children who warrant further investigation. In children who present with multiple fractures that are not commonly associated with mild to moderate...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2015.04.006
更新日期：2015-08-01 00:00:00
abstract：:Breast lesions, including mastalgia; benign proliferative changes; and benign masses, including fibroadenomas, are common in adolescents and young adult women. Breast cancer is rare in women less than 20 years old and uncommon in women less than 30 years old. Discrete masses in women less than 30 years old that do not...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(05)70140-1
更新日期：1999-06-01 00:00:00
abstract：:Children with persistent neurodevelopmental and neuropsychiatric problems have extensive treatment, care, and community service needs. The child's disabilities can create new responsibilities, emotions, roles, and goals for the family. This article provides a framework for identifying and categorizing children with sp...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)38914-3
更新日期：1995-02-01 00:00:00
abstract：:Musculoskeletal pain is one of the most common presenting symptoms at the pediatrician's office. Etiology ranges from benign conditions to serious ones requiring prompt attention. This article addresses entities that present as musculoskeletal pain but are not associated with arthritis. The most common nonarthritic co...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2012.03.012
更新日期：2012-04-01 00:00:00
abstract：:Deformities are abnormalities of shape or form caused by abnormal or imbalanced mechanical forces. In prenatal deformation, most infants are intrinsically normal and the deformation results from extrinsic constraining forces. Most prenatal deformities will resolve spontaneously or with the application of counteracting...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章
doi：10.1016/s0031-3955(16)36142-9
更新日期：1986-12-01 00:00:00
abstract：:Increasing evidence indicates that the circadian timing system is a fundamental hemostatic system that potently influences human behavior and physiology throughout development. Circadian clock function begins during fetal life, and photic regulation of circadian phase is present at birth in primates. After birth, ther...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(05)70486-7
更新日期：1997-04-01 00:00:00
abstract：:The stress response in humans commonly includes elevations in plasma concentrations of glucocorticoids, catecholamines, glucagon, growth hormone, aldosterone, and renin, resulting in alterations in the metabolism of glucose and other energy substrates, and in increased sodium and water retention. In severe illness, tr...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)36185-5
更新日期：1987-02-01 00:00:00
abstract：:In summary, wheezing is a common manifestation of viral respiratory tract disease in infancy. The precise pathogenetic mechanisms of virus-induced wheezing and its sequelae are not clear, although recent reports about participation of the cellular and humoral immune systems are promising. Although therapies like those...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0031-3955(16)36545-2
更新日期：1988-10-01 00:00:00
abstract：:Acute pharyngitis is one of the most common illnesses for which children visit primary care physicians. Most cases of acute pharyngitis in children are caused by viruses and are benign and self-limited. Group A beta-hemolytic streptococcus is the most important of the bacterial causes of acute pharyngitis. Strategies ...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2005.02.004
更新日期：2005-06-01 00:00:00
abstract：:Vitiligo is a disease of pigment loss. Most investigators currently consider vitiligo to be a disorder that occurs as a result of autoimmune destruction of melanocytes, supported by identification of antimelanocyte antibodies in many patients, and the presence of comorbid autoimmune disease in patients with and family...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2013.11.008
更新日期：2014-04-01 00:00:00
abstract：:The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserved microbial components. This deployment generates a rapid inflammatory response, while activating the adaptive immune system. Improvements in our understanding of the innate immune syste...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2019.06.011
更新日期：2019-10-01 00:00:00
abstract：:In today's complex and rapidly changing health care environments, patient harm may result if important patient information is not communicated from one health care provider to another during handoffs in care. Issues involving communication, continuity of care, and care planning are cited as a root cause in more than 8...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2006.09.010
更新日期：2006-12-01 00:00:00
abstract：:The causes of macroscopic and microscopic hematuria overlap; both are often caused by urinary tract infections or urethral/bladder irritation. Coexistent hypertension and proteinuria should prompt investigation for glomerular disease. The most common glomerulonephritis in children is postinfectious glomerulonephritis....
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2018.08.003
更新日期：2019-02-01 00:00:00
abstract：:Community-acquired pneumonia (CAP) occurs more often in early childhood than at almost any other age. Many microorganisms are associated with pneumonia, but individual pathogens are difficult to identify, which poses problems in antibiotic management. This article reviews the common as well as new, emerging pathogens,...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2012.12.009
更新日期：2013-04-01 00:00:00
abstract：:The last decade has seen an increase of interest in autism spectrum disorders (ASD). With the prevalence now approaching 1%, children with ASD are usually first evaluated by clinicians working in primary care, such as pediatricians and family practitioners. Although classic autism is easy to recognize, differentiating...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2011.10.007
更新日期：2012-02-01 00:00:00
abstract：:It has been speculated that autism and specific language impairment share common underlying neural substrates because of the overlap in language impairment issues and evidence suggesting parallels in other domains and implying a possible shared genetic risk. Anatomically the two sets of disorders have generally been s...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2007.02.007
更新日期：2007-06-01 00:00:00
abstract：:Bleeding disorders are broadly classified into primary and secondary hemostatic defects. Primary hemostatic disorders (disorders of platelets and von Willebrand factor) mainly result in mucocutaneous bleeding symptoms such as epistaxis, menorrhagia, petechiae, easy bruising, and bleeding after dental and surgical inte...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2013.09.002
更新日期：2013-12-01 00:00:00
abstract：:The benefits and possible detriment of resistance training have been noted extensively in the literature. Although the benefits of resistance training are well known, many professionals fail to heed scientific advice or follow appropriate recommendations for resistance training in adolescents. When developing a resist...
journal_title：Pediatric clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.pcl.2010.02.009
更新日期：2010-06-01 00:00:00
