Optimizing diabetes treatment in the presence of obesity.

Abstract:

:Evidence of a neurophysiologic mechanism that involves hormones from adipocytes, pancreatic islet cells, and the gastrointestinal tract implicated in both obesity and diabetes has led to a search for drugs that not only either target obesity and diabetes or reduce hemoglobin A1c, but also have weight loss as a potential side effect. The authors review medications approved for the treatment of type 2 diabetes mellitus (including pramlintide, also approved for type 1 diabetes) that also have weight loss as a side effect. Drugs discussed include glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, neuroendocrine peptide hormones, alpha-glucosidase inhibitors, and metformin. Where appropriate, the authors comment on the cardiovascular effects of these drugs.

journal_name

Cleve Clin J Med

authors

Esquivel MA,Lansang MC

doi

10.3949/ccjm.84.s1.04

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

S22-S29

issue

7 Suppl 1

eissn

0891-1150

issn

1939-2869

journal_volume

84

pub_type

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