Abstract:
OBJECTIVE:The polymorphism in codon 399 of the X-ray repair cross-complementing group 1 (XRCC1) gene may subtly alter structure of DNA repair enzymes and modulate the repair capacity. Impaired DNA repair can lead to the development of cancers such as prostate cancer (PCA). Although the association between the XRCC1 codon 399 polymorphism and PCA risk has been extensively reported, the results have been ambiguous. METHODS:We conducted an updated analysis of 18 case-control studies to determine the association between the XRCC1 codon 399 polymorphism and PCA risk. We performed a literature search of the PubMed database to identify all eligible articles that reported this association. Odds ratios (ORs) with 95% confidence intervals (CI) were evaluated to assess the association. RESULTS:Significant associations between PCA risk and XRCC1 codon 399 polymorphism were found (such as A-allele vs. G-allele: OR = 1.11, 95% CI = 1.01-1.23). Moreover, subgroup analysis based on ethnicity revealed similar significant associations in Asians (such as AA vs. GG: OR = 1.53, 95% CI = 1.19-1.97). Egger's test did not reveal the presence of a publication bias. CONCLUSIONS:Our updated analysis provides evidence for significant association between XRCC1 codon 399 polymorphism and PCA risk. Further carefully designed studies should be performed.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Yuanyuan M,Xiaoming Y,Lijie Z,Ninghan Fdoi
10.12669/pjms.315.7510subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1130-5issue
5eissn
1682-024Xissn
1681-715Xpii
PJMS-31-1130journal_volume
31pub_type
杂志文章abstract::A 33-year-old woman with very poor health status was admitted to our hospital because she had experienced increasing abdominal distention for three months, CT examination showed a right ovarian tumor together with massive abdominal and pelvic fluid. The patient was first treated by continuous circulatory hypothermic i...
journal_title:Pakistan journal of medical sciences
pub_type:
doi:10.12669/pjms.292.2981
更新日期:2013-04-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.311.5864
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.336.12900
更新日期:2017-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.306.5584
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.3.980
更新日期:2019-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.1.295
更新日期:2019-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章,评审
doi:10.12669/pjms.322.9435
更新日期:2016-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.336.13488
更新日期:2017-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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doi:10.12669/pjms.37.1.3034
更新日期:2021-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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更新日期:2013-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.316.8204
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.313.8003
更新日期:2015-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.5.812
更新日期:2019-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.334.13063
更新日期:2017-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.303.4985
更新日期:2014-05-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.3.972
更新日期:2019-01-01 00:00:00
abstract:Objectives:To estimate the incidence of microvascular complications among subjects with type 2 diabetes at a tertiary care hospital. Methods:This retrospective longitudinal follow-up study assessed the data records of type 2 diabetic subjects who visited the outpatient department of Baqai Institute of Diabetology and ...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.345.15224
更新日期:2018-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.344.14602
更新日期:2018-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.37.1.3089
更新日期:2021-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.335.13221
更新日期:2017-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.2.668
更新日期:2020-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.343.14345
更新日期:2018-05-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.COVID19-S4.2785
更新日期:2020-05-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.326.10995
更新日期:2016-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the Bone Mineral Density (BMD) and diet of teachers of a Govt. College of Home Economics in Lahore. METHODS:It was survey research. Purposive sampling technique was adopted for the selection of 50 teachers from Govt. College of Home Economics of age group 30 - 60 years. RESULTS:About 46% of the ...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.314.8433
更新日期:2015-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.316.7714
更新日期:2015-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.291.2865
更新日期:2013-01-01 00:00:00
abstract:Objective:To investigate the predictive validity of Uniform Entrance Test for academic performance in the first two years in various health science degree programs. Methods:A retrospective analysis of admissions data and academic performance of students admitted in under-graduate programs of medicine, dentistry and ph...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.2.334
更新日期:2019-03-01 00:00:00