Controversies and Advances With Testosterone Therapy: A 40-Year Perspective.

Abstract:

:Testosterone therapy (TTh) has become highly controversial. There are important health consequences of testosterone deficiency, and meaningful benefits with treatment. There is level 1 evidence that TTh improves sexual function and desire, body composition, and bone density. Concerns regarding cardiovascular risk were based on two deeply flawed retrospective studies and are contradicted by dozens of studies showing cardiovascular benefits of TTh or higher endogenous testosterone, including placebo-controlled studies in men with known heart disease (angina, heart failure). Prostate cancer should no longer be considered a risk of TTh. Testosterone is neither scourge nor panacea--it is just good medicine.

journal_name

Urology

journal_title

Urology

authors

Morgentaler A

doi

10.1016/j.urology.2015.11.034

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

27-32

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(15)01106-1

journal_volume

89

pub_type

杂志文章,评审

相关文献

UROLOGY文献大全
  • Postchemotherapy retroperitoneal lymph node dissection is effective therapy in selected patients with elevated tumor markers after primary chemotherapy alone.

    abstract:OBJECTIVES:Elevated tumor markers after primary chemotherapy for metastatic testis cancer are usually an indication of persistent cancer. Subsequent treatment has usually been salvage chemotherapy. This article examines the possibility that selected patients can achieve long-term disease-free survival with surgery alon...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/S0090-4295(97)00458-5

    authors: Coogan CL,Foster RS,Rowland RG,Bihrle R,Smith ER Jr,Einhorn LH,Roth BJ,Donohue JP

    更新日期:1997-12-01 00:00:00

  • Mast cell involvement in interstitial cystitis: a review of human and experimental evidence.

    abstract::Interstitial cystitis (IC) is a heterogeneous syndrome of unknown etiology. Altered bladder glycosaminoglycans lining and bladder mastocytosis have been documented in IC. The objective of this article is to critically examine the published data on bladder mastocytosis in clinical, experimental, and animal studies, wit...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/s0090-4295(01)01129-3

    authors: Theoharides TC,Kempuraj D,Sant GR

    更新日期:2001-06-01 00:00:00

  • Estimation of prostate size in community-dwelling men.

    abstract:OBJECTIVES:To use two population-based samples of prostate cancer-free men to develop and validate a novel multivariable equation for estimating prostate volume (PV). Previous investigators have demonstrated the ability to use serum prostate-specific antigen (PSA) levels to estimate PV in men without prostate cancer; h...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.05.044

    authors: Jacobson DJ,St Sauver JL,Parker AS,McGree ME,Sarma AV,Girman CJ,Lieber MM,Jacobsen SJ

    更新日期:2011-02-01 00:00:00

  • Individualized Physical 3-dimensional Kidney Tumor Models Constructed From 3-dimensional Printers Result in Improved Trainee Anatomic Understanding.

    abstract:OBJECTIVE:To evaluate the effect of 3-dimensionally (3D) printed physical renal models with enhancing masses on medical trainee characterization, localization, and understanding of renal malignancy. METHODS:Proprietary software was used to import standard computed tomography (CT) cross-sectional imaging into 3D printe...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2015.02.053

    authors: Knoedler M,Feibus AH,Lange A,Maddox MM,Ledet E,Thomas R,Silberstein JL

    更新日期:2015-06-01 00:00:00

  • A New Technique: Laparoscopic Resection of Fibrous Ring and Placing Extravascular Stent in Patients With Nutcracker Syndrome: A Report of 5 Cases.

    abstract:OBJECTIVE:To evaluate the feasibility and safety of a new laparoscopic technique for resection of a fibrous ring and extravascular stent implantation in patients with nutcracker syndrome (NCS). MATERIAL AND METHODS:We retrospectively reviewed data of 5 patients diagnosed with NCS between March 2010 and February 2016. ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2018.12.039

    authors: Chen FM,Chen XL,Jiang XN,Tang S,Shi JQ,Li DB,Zhong SW,Chen Y

    更新日期:2019-04-01 00:00:00

  • Botulinum Toxin Type A Injection After Failure of Augmentation Enterocystoplasty Performed for Neurogenic Detrusor Overactivity: Preliminary Results of a Salvage Strategy. The ENTEROTOX Study.

    abstract:OBJECTIVE:To evaluate the clinical efficacy, urodynamic effect and safety of Botulinum Toxin A (BTXA) injections after failure of augmentation enterocystoplasty (AE) performed for neurogenic detrusor overactivity. PATIENTS AND METHODS:We performed a multicenter retrospective study that included patients who had AE and...

    journal_title:Urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.urology.2019.03.010

    authors: Michel F,Ciceron C,Bernuz B,Boissier R,Gaillet S,Even A,Chartier-Kastler E,Denys P,Gamé X,Ruffion A,Normand LL,Perrouin-Verbe B,Saussine C,Manunta A,Forin V,De Seze M,Grise P,Tournebise H,Schurch B,Karsenty G

    更新日期:2019-07-01 00:00:00

  • Implementation of a Tele-urology Program for Outpatient Hematuria Referrals: Initial Results and Patient Satisfaction.

    abstract:OBJECTIVE:To report on results from a new tele-urology pathway for managing hematuria consults, including a survey of patient attitudes and satisfaction with such a program. Recent guideline changes have relaxed the definition of microscopic hematuria and may have significantly increased the number of hematuria evaluat...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2016.04.066

    authors: Safir IJ,Gabale S,David SA,Huang JH,Gerhard RS,Pearl J,Lorentz CA,Baumgardner J,Filson CP,Issa MM

    更新日期:2016-11-01 00:00:00

  • Vena caval reconstruction during postchemotherapy retroperitoneal lymph node dissection for metastatic germ cell tumor.

    abstract::We present our experience with inferior vena cava (IVC) reconstruction in patients undergoing post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) due to metastatic germ cell tumor. Four patients underwent IVC reconstruction with a prosthetic graft. Early postoperative leg edema was prevented in all 4. L...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.02.054

    authors: Ehrlich Y,Kedar D,Zelikovski A,Konichezky M,Baniel J

    更新日期:2009-02-01 00:00:00

  • Role of cellular oxalate in oxalate clearance of patients with calcium oxalate monohydrate stone formation and normal controls.

    abstract:OBJECTIVES:To examine the cellular, plasma, and urinary oxalate and erythrocyte oxalate flux in patients with calcium oxalate monohydrate (COM) stone formation vs normal controls. Pathologic oxalate clearance in humans is mostly integrated in calcium oxalate stone formation. An underlying cause of deficient oxalate cle...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.11.028

    authors: Oehlschläger S,Fuessel S,Meye A,Herrmann J,Froehner M,Albrecht S,Wirth MP

    更新日期:2009-03-01 00:00:00

  • Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1.

    abstract:OBJECTIVE:To describe the establishment and characterization of a human cell line, SEM-1, from a patient diagnosed with a mediastinal seminoma. METHODS:A small percentage of germ cell tumors develop as primary lesions in extragonadal sites, and the etiology of these tumors is poorly understood. Currently, only 2 cell ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.09.029

    authors: Russell SM,Lechner MG,Mokashi A,Megiel C,Jang JK,Taylor CR,Looijenga LH,French CA,Epstein AL

    更新日期:2013-02-01 00:00:00

  • Tyrosine kinase inhibitors and signal transduction modulators: Rationale and current status as chemopreventive agents for prostate cancer.

    abstract::Cell growth and differentiation are processes intimately associated with carcinogenesis and regulated by tyrosine kinases and other signaling proteins. Identification of drugs that target signaling molecules is hampered by both the large number of targets and the complex nature of signaling cascades. Optimal developme...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)00946-8

    authors: Bergan RC,Waggle DH,Carter SK,Horak I,Slichenmyer W,Meyers M

    更新日期:2001-04-01 00:00:00

  • Testicular volume measurements using Prader orchidometer versus ultrasonography in patients with infertility.

    abstract:OBJECTIVES:To compare the accuracy of testicular volume measurements with the Prader orchidometer versus ultrasonography. METHODS:The volume of 938 testes in 469 men with infertility (mean age 35.8 years) was measured using a Prader orchidometer and by ultrasonography. The ultrasound testicular volumes were calculated...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2006.09.013

    authors: Sakamoto H,Saito K,Ogawa Y,Yoshida H

    更新日期:2007-01-01 00:00:00

  • Impact of patient educational level on treatment for patients with prostate cancer: data from CaPSURE.

    abstract:OBJECTIVES:To examine the effect of a patient's educational level on treatment selection for patients with newly diagnosed prostate cancer. A patient's educational level may impact a patient's understanding and perception of the risks and benefits of the treatment options for prostate cancer. METHODS:We examined 3484 ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(03)00778-7

    authors: Kane CJ,Lubeck DP,Knight SJ,Spitalny M,Downs TM,Grossfeld GD,Pasta DJ,Mehta SS,Carroll PR

    更新日期:2003-12-01 00:00:00

  • Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.

    abstract:OBJECTIVE:To evaluate the consequence of pharmacologic inhibition of voltage-gated Na(+) channels (Nav) in the conscious rat, based on Nav having been implicated as modulators of rodent urodynamics using knockout as well as antisense oligodeoxynucleotide approaches. METHODS:The urodynamic response to standard Nav bloc...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.02.016

    authors: Clouse AK,Jugus MJ,Eisennagel SH,Laping NJ,Westfall TD,Thorneloe KS

    更新日期:2012-06-01 00:00:00

  • Primary granulocytic sarcoma of the urinary bladder: case report and review of the literature.

    abstract::We report a case of granulocytic sarcoma of the urinary bladder, with no evidence of hematologic involvement. The patient was initially misdiagnosed and was treated with chemotherapy for transitional carcinoma grade 3. Despite this treatment, the clinical features of the patient progressed, and a repeated biopsy yield...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/s0090-4295(02)01750-8

    authors: Aki H,Baslar Z,Uygun N,Ozguroglu M,Tuzuner N

    更新日期:2002-08-01 00:00:00

  • Prostate cancer presenting with malignant ascites: signet-ring cell variant of prostatic adenocarcinoma.

    abstract::A case of prostate cancer presenting with malignant ascites as the sole clinical manifestation is reported. The clinical course simulated occult gastrointestinal malignancy. At the histologic level, the tumor had a signet-ring morphology. Detailed immunocytochemical and ultrastructural studies, however, confirmed the ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(92)90259-y

    authors: Catton PA,Hartwick RW,Srigley JR

    更新日期:1992-05-01 00:00:00

  • Erectile and ejaculatory dysfunction in a community-based sample of men 50 to 78 years old: prevalence, concern, and relation to sexual activity.

    abstract:OBJECTIVES:To determine the prevalence rates of erectile and ejaculatory dysfunction, associated bother, and their relation to sexual activity in a population-based sample of elderly men.Methods. Data were collected from 1688 men by way of self-administered questionnaires (including the International Continence Society...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)01091-8

    authors: Blanker MH,Bosch JL,Groeneveld FP,Bohnen AM,Prins A,Thomas S,Hop WC

    更新日期:2001-04-01 00:00:00

  • Effects of sildenafil on human penile blood vessels.

    abstract:OBJECTIVES:To investigate the effects of sildenafil on human penile blood vessels and evaluate the interaction of sildenafil with neurogenic-mediated responses. Sildenafil is currently used in the treatment of erectile dysfunction. METHODS:Penile dorsal arteries and deep dorsal veins were obtained from 14 multiorgan d...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)00622-1

    authors: Medina P,Segarra G,Vila JM,Domenech C,Martínez-León JB,Lluch S

    更新日期:2000-09-01 00:00:00

  • Assessment of biochemical recurrence rate in patients with pathologically confirmed insignificant prostate cancer.

    abstract:OBJECTIVES:To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa). METHODS:A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.04.053

    authors: Capitanio U,Ahyai S,Graefen M,Jeldres C,Shariat SF,Erbersdobler A,Schlomm T,Haese A,Steuber T,Heinzer H,Perrotte P,Péloquin F,Pharand D,Arjane P,Huland H,Karakiewicz PI

    更新日期:2008-12-01 00:00:00

  • Impact of superficial bladder cancer and transurethral resection on general health-related quality of life: an SF-36 survey.

    abstract:OBJECTIVES:To assess the general health-related quality of life (GHQOL) of patients with superficial bladder cancer who underwent transurethral resection (TUR). METHODS:We assessed the GHQOL a total of 178 times for 133 patients with superficial bladder cancer before multiple TURs. The GHQOL was assessed using the Med...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.09.050

    authors: Yoshimura K,Utsunomiya N,Ichioka K,Matsui Y,Terai A,Arai Y

    更新日期:2005-02-01 00:00:00

  • Invasively estimated International Continence Society obstruction classification versus noninvasively assessed bladder outlet obstruction probability in treatment recommendation for LUTS suggestive of BPH.

    abstract:OBJECTIVES:To investigate the contribution of urodynamically proven presence or absence (International Continence Society classification) of bladder outlet obstruction (BOO) to treatment recommendations for lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia, and to investigate the impact of ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2006.10.039

    authors: Boormans JL,van Venrooij GE,Boon TA

    更新日期:2007-03-01 00:00:00

  • Selective Trans-arterial Embolization of Iatrogenic Vascular Lesions Did Not Influence the Global Renal Function After Partial Nephrectomy.

    abstract:OBJECTIVE:To evaluate the renal function outcomes after selective trans-arterial embolization (SAE) of iatrogenic vascular lesions (IVL), including pseudoaneurysm and arteriovenous fistula, following partial nephrectomy (PN). MATERIALS AND METHODS:A multi-institutional study was conducted including consecutive patient...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.03.036

    authors: Baboudjian M,Gondran-Tellier B,Abdallah R,Lannes F,Sichez PC,Akiki A,Gaillet S,Toledano H,Delaporte V,Andre M,Karsenty G,Lechevallier E,Rossi D,Vidal V,Boissier R,Bastide C

    更新日期:2020-07-01 00:00:00

  • Role of molecular markers in the diagnosis and therapy of renal cell carcinoma.

    abstract::Recent advances in the understanding of the pathogenesis, behavior, and molecular biology of renal cell carcinoma (RCC) have paved the way for developments that may enhance early diagnosis, better predict prognosis, and improve survival. Reliable predictive factors are essential for the stratification of patients into...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2005.06.112

    authors: Lam JS,Leppert JT,Figlin RA,Belldegrun AS

    更新日期:2005-11-01 00:00:00

  • Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis.

    abstract:OBJECTIVES:To assess the clinical factors that affect the efficacy of hyperbaric oxygen (HBO2) therapy in treating radiation-induced hemorrhagic cystitis. HBO2 therapy is an effective treatment for radiation-induced hemorrhagic cystitis, with reported response rates ranging from 76% to 100%. METHODS:The data from pati...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.10.050

    authors: Chong KT,Hampson NB,Corman JM

    更新日期:2005-04-01 00:00:00

  • Effect of stone composition on operative time during ureteroscopic holmium:yttrium-aluminum-garnet laser lithotripsy with active fragment retrieval.

    abstract:OBJECTIVE:To assess whether the stone composition affects the operative time of ureteroscopic holmium:yttrium-aluminum-garnet laser lithotripsy (ULL) with active fragment retrieval. The chemical composition of a calculus is known to affect the efficacy with which it is fragmented by a device, such as pneumatic, laser, ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.05.040

    authors: Wiener SV,Deters LA,Pais VM Jr

    更新日期:2012-10-01 00:00:00

  • Relationship between patient age and superficial transitional cell carcinoma characteristics.

    abstract:OBJECTIVES:To evaluate the relationship between patient age and the characteristics of superficial transitional cell carcinoma. METHODS:The clinical and pathologic records of 576 patients were retrospectively reviewed. The patients were classified into three groups: those 40 years or younger, those 41 to 59 years old,...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2008.01.062

    authors: Shi B,Zhang K,Zhang J,Chen J,Zhang N,Xu Z

    更新日期:2008-06-01 00:00:00

  • Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo.

    abstract:OBJECTIVES:To investigate the effects of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac on prostate cancer cell lines in vitro and in vivo and on E-cadherin expression in prostate cancer cells. METHODS:We evaluated the cytotoxicity of etodolac on the three prostate cancer cell lines LNCaP, C4-2, and PC-3. W...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2005.06.076

    authors: Shigemura K,Shirakawa T,Wada Y,Kamidono S,Fujisawa M,Gotoh A

    更新日期:2005-12-01 00:00:00

  • Laparoscopic partial nephrectomy: a matched-pair comparison of the transperitoneal versus the retroperitoneal approach.

    abstract:OBJECTIVES:To compare surgical and functional results of both surgical approaches to endoscopic partial nephrectomy. It is currently performed either by the transperitoneal (t) or the retroperitoneal (r) approach. METHODS:This was a retrospective, matched-pair comparison of 105 patients who underwent either transperit...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.02.057

    authors: Marszalek M,Chromecki T,Al-Ali BM,Meixl H,Madersbacher S,Jeschke K,Pummer K,Zigeuner R

    更新日期:2011-01-01 00:00:00

  • Laparoendoscopic single-site radical cystectomy and pelvic lymph node dissection: initial experience and 2-year follow-up.

    abstract:OBJECTIVE:To report the first series of laparoendoscopic single-site surgery for radical cystectomy and bilateral pelvic lymph node dissection. The development of laparoendoscopic single-site surgery and its application to urothelial malignancy has not been previously evaluated. METHODS:A novel, single multichannel po...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.04.024

    authors: Kaouk JH,Goel RK,White MA,White WM,Autorino R,Haber GP,Campbell SC

    更新日期:2010-10-01 00:00:00

  • Percutaneous transperineal cryosurgical ablation of the prostate for the primary treatment of clinical stage C adenocarcinoma of the prostate.

    abstract:OBJECTIVES:To assess short-term response rate and local tissue destructive capabilities of cryosurgical ablation of the prostate (CSAP) in patients with clinical Stage C adenocarcinoma of the prostate. METHODS:A retrospective chart review of 62 patients (mean age, 66 years; range, 49 to 79 years) treated on an institu...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(94)80122-3

    authors: Miller RJ Jr,Cohen JK,Merlotti LA

    更新日期:1994-08-01 00:00:00