Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo.

Abstract:

OBJECTIVES:To investigate the effects of the selective cyclooxygenase-2 (COX-2) inhibitor etodolac on prostate cancer cell lines in vitro and in vivo and on E-cadherin expression in prostate cancer cells. METHODS:We evaluated the cytotoxicity of etodolac on the three prostate cancer cell lines LNCaP, C4-2, and PC-3. We also performed quantitative real-time polymerase chain reaction to measure the mRNA expression of COX-2, Bcl-2, and E-cadherin in these cell lines after etodolac treatment. In addition, we investigated the in vivo antitumor effects of etodolac on a human prostate cancer xenograft model. RESULTS:Etodolac exhibited significant antitumor effect in vivo and in vitro. The cytotoxicity of etodolac in LNCaP and C4-2 was markedly increased at a dose of 1000 nM in a time-dependent and dose-dependent manner. In the in vivo tumor growth study, the etodolac-treated mice exhibited more significant cytotoxicity than the phosphate-buffered saline-treated mice. Expression of E-cadherin after etodolac treatment tended to increase and that of Bcl-2 to decrease, but the expression of COX-2 had no definite tendency. CONCLUSIONS:The COX-2 inhibitor etodolac exhibited an antitumor effect on prostate cancer cell lines in vitro and in vivo, and it might be useful for the treatment of hormone-resistant prostate cancer.

journal_name

Urology

journal_title

Urology

authors

Shigemura K,Shirakawa T,Wada Y,Kamidono S,Fujisawa M,Gotoh A

doi

10.1016/j.urology.2005.06.076

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1239-44

issue

6

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(05)00894-0

journal_volume

66

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • Trial endpoints for drug approval in oncology: Chemoprevention.

    abstract::As with other drugs, new drug applications for marketing approval of chemopreventive drugs must include data from adequate and well-controlled clinical trials that demonstrate effectiveness and safety for the intended use. This article summarizes the regulatory requirements for traditional marketing approval, as well ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)00977-8

    authors: Beitz J

    更新日期:2001-04-01 00:00:00

  • Luteinizing hormone-releasing hormone (LHRH) agonists for treatment of advanced prostatic carcinoma.

    abstract::The identification of the decapeptide luteinizing hormone-releasing hormone (LHRH) has led to the development of LHRH agonists, which are a new class of drugs for the treatment of advanced prostate cancer. These peptides have a modified amino acid structure that makes them more potent than LHRH. Prolonged administrati...

    journal_title:Urology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1016/0090-4295(89)90105-2

    authors: Chodak GW

    更新日期:1989-05-01 00:00:00

  • A rare case of classic testicular seminoma in an 86-year-old shows similar proliferation rate as in younger men.

    abstract::We present a rare case of classic seminoma in an 86-year-old man. Combined mitotic count, the presence or absence of intravascular invasion, and the expression of PCNA, Ki67, and p53 were compared between this octogenarian and the tumors of four randomly selected standard younger men. These histologic features were ch...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2007.08.006

    authors: Foell K,Martens M,Izawa JI

    更新日期:2007-11-01 00:00:00

  • Botulinum Toxin Type A Injection After Failure of Augmentation Enterocystoplasty Performed for Neurogenic Detrusor Overactivity: Preliminary Results of a Salvage Strategy. The ENTEROTOX Study.

    abstract:OBJECTIVE:To evaluate the clinical efficacy, urodynamic effect and safety of Botulinum Toxin A (BTXA) injections after failure of augmentation enterocystoplasty (AE) performed for neurogenic detrusor overactivity. PATIENTS AND METHODS:We performed a multicenter retrospective study that included patients who had AE and...

    journal_title:Urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.urology.2019.03.010

    authors: Michel F,Ciceron C,Bernuz B,Boissier R,Gaillet S,Even A,Chartier-Kastler E,Denys P,Gamé X,Ruffion A,Normand LL,Perrouin-Verbe B,Saussine C,Manunta A,Forin V,De Seze M,Grise P,Tournebise H,Schurch B,Karsenty G

    更新日期:2019-07-01 00:00:00

  • Radiographic prognostic criteria for extracorporeal shock-wave lithotripsy: a study of 485 patients.

    abstract:OBJECTIVES:We studied 485 patients treated by extracorporeal shock-wave lithotripsy (ESWL) using an ultrasound electrohydraulic apparatus in an effort to define radiographic criteria for better patient selection for ESWL. METHODS:Results were assessed according to plain x-ray nephrotomography and ultrasound. The crite...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(96)00251-8

    authors: Bon D,Dore B,Irani J,Marroncle M,Aubert J

    更新日期:1996-10-01 00:00:00

  • Serum testosterone-based luteinizing hormone-releasing hormone agonist redosing schedule for chronic androgen ablation: a phase I assessment.

    abstract:OBJECTIVES:To assess the potential for using the serum testosterone level as the guide for redosing depot luteinizing hormone-releasing hormone (LHRH) agonist and to characterize the duration of castrate level testosterone after the last 22.5-mg leuprolide injection repeatedly administered for the control of prostate c...

    journal_title:Urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0090-4295(99)00316-7

    authors: Oefelein MG

    更新日期:1999-10-01 00:00:00

  • Prevalence of nephrolithiasis in patients with ileal bladder substitutes.

    abstract:OBJECTIVES:To assess the effect of ileal bladder substitutes with preservation of the ileocecal valve and distal 25 cm of ileum on nephrolithiasis. METHODS:We reviewed a consecutive series of 518 patients (44 women and 474 men) with ileal orthotopic bladder substitution in whom 55 to 65 cm of ileum was resected but wi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2007.08.058

    authors: Dhar NB,Hernandez AV,Reinhardt K,Giannarini G,Zehnder P,Müller RM,Studer UE

    更新日期:2008-01-01 00:00:00

  • Incidence of perioperative urinary tract infection after single-dose antibiotic therapy for midurethal slings.

    abstract:OBJECTIVES:A recent Best Practice Statement published by the American Urological Association (AUA) recommends that antibiotic therapy in patients undergoing midurethral synthetic slings (MUS) should be 24 hours or less. Subjects at our institution are routinely administered a single dose of intravenous antibiotics befo...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.05.038

    authors: Ingber MS,Vasavada SP,Firoozi F,Goldman HB

    更新日期:2010-10-01 00:00:00

  • Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

    abstract:OBJECTIVE:To investigate the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) protein in the interstitial cells of Cajal (ICCs) of the human bladder and to determine the relative expression of the HCN subtypes. METHODS:A total of 30 bladder specimens were obtained, and each bladder sample was di...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2012.04.005

    authors: Xue L,Li Y,Han X,Yao L,Yuan J,Qin W,Liu F,Wang H

    更新日期:2012-07-01 00:00:00

  • Plasma renin activity revealed renal artery stenosis concealed by aneurysms.

    abstract::We describe a case of renovascular hypertension with renal artery stenosis concealed by aneurysms. Arteriography demonstrated no apparent renal artery stenosis, but did reveal aneurysms on the left renal artery. Captopril-loaded renoscintigraphy could not detect disturbed renal perfusion. High basal and exaggerated pl...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.09.045

    authors: Tanemoto M,Abe T,Satoh F,Ito S

    更新日期:2005-03-01 00:00:00

  • Bladder calculi in augmentation cystoplasty in children.

    abstract:OBJECTIVES:To determine the best preventive strategies for bladder calculi in children with an augmented bladder, the risk factors and prevention strategies for urolithiasis were evaluated. METHODS:The records of 89 patients following augmentation cystoplasty were reviewed to assess the results of augmentation cystopl...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)00663-4

    authors: Mathoera RB,Kok DJ,Nijman RJ

    更新日期:2000-09-01 00:00:00

  • T3 bladder cancer: salvage rather than elective cystectomy after radiotherapy.

    abstract::Treatment of a series of 194 patients with T3 (B2/C) tumors by radical radiotherapy, 5,000 to 5,500 rad in four weeks, produced a five-year survival of 40 per cent. Patients whose tumor completely disappeared after treatment (N = 97) had a five-year survival of 69 per cent. These results raise doubts about the necessi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(84)90199-7

    authors: Hope-Stone HF,Oliver RT,England HR,Blandy JP

    更新日期:1984-10-01 00:00:00

  • Coenzyme Q10 Intake From Food and Semen Parameters in a Subfertile Population.

    abstract:OBJECTIVE:To assess the association between coenzyme Q10 (CoQ10) intake from food sources and semen quality. We assessed this association in a prospective cohort of men attending a fertility clinic. CoQ10 supplementation has been associated with improvements in semen parameters. However, the impact of CoQ10 intake from...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2016.11.022

    authors: Tiseo BC,Gaskins AJ,Hauser R,Chavarro JE,Tanrikut C,EARTH Study Team.

    更新日期:2017-04-01 00:00:00

  • Interferon alfa and vinblastine versus medroxyprogesterone acetate in the treatment of metastatic renal cell carcinoma.

    abstract:OBJECTIVES:Since the beginning of the 1980s, when gene technology provided sufficient amounts of cytokines, numerous Phase II studies in metastatic renal cell carcinoma were carried out mostly with interferon alfa (IFN-alpha) and interleukin-2 (IL-2). So far, no randomized prospective trials including untreated control...

    journal_title:Urology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/S0090-4295(99)80079-X

    authors: Kriegmair M,Oberneder R,Hofstetter A

    更新日期:1995-05-01 00:00:00

  • Paraurethral cysts in female neonate.

    abstract::Paraurethral cysts in the female neonate are uncommon lesions. All reported cases have either ruptured spontaneously or responded to simple marsupialization. However, complete urologic evaluation is mandatory because they simulate ectopic ureteroceles in appearance. Herein is reported our experience with 5 patients. T...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(76)90191-6

    authors: Blaivas JG,Pais VM,Retik AB

    更新日期:1976-05-01 00:00:00

  • Use of stone brush for treatment of impacted stones in association with extracorporeal shock-wave lithotripsy.

    abstract::A new device is described which enhances the treatment of impacted stones in association with the extracorporeal shock-wave lithotripsy. This technique may result in decreased number of shocks and increased efficiency, as well as, enhance outpatient treatment. ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(90)80066-v

    authors: Rubenstein MA,Norris DM

    更新日期:1990-02-01 00:00:00

  • Extended Case Duration and Hypotension Are Associated With Higher-grade Postoperative Complications After Urinary Diversion for Non-oncological Disease.

    abstract:OBJECTIVE:To report survival for patients who undergo urinary diversion for benign indications and to identify risk factors for morbidity at 90 days. METHODS:This is a retrospective review of consecutive urinary diversions with or without cystectomy for non-oncological indications at a single institution. The indicati...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2017.05.061

    authors: Santiago-Lastra Y,Mathis MR,Andraska E,Thompson AL,Malaeb BS,Cameron AP,Clemens JQ,Stoffel JT

    更新日期:2018-01-01 00:00:00

  • Comparison of bladder rupture pressure after intestinal bladder augmentation (ileocystoplasty) and myomyotomy (autoaugmentation).

    abstract:OBJECTIVES:To compare the risk of bladder rupture of bladder augmentation using ileocystoplasty versus that of autoaugmentation with myomyotomy in a rat model. METHODS:Bladder rupture pressure and volume of three groups of female Sprague-Dawley rats were determined by cystometry. The first group of 11 rats had undergo...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(96)00096-9

    authors: Rivas DA,Chancellor MB,Huang B,Epple A,Figueroa TE

    更新日期:1996-07-01 00:00:00

  • Effect of early adrenal vein ligation on blood pressure and catecholeamine fluctuation during laparoscopic adrenalectomy for pheochromocytoma.

    abstract:OBJECTIVE:To define whether previous control of the adrenal vein is a crucial procedure in laparoscopic adrenalectomy for pheochromocytoma. METHODS:From January 2000 to December 2010, 114 patients with pheochromocytoma who underwent laparoscopic adrenalectomy through transperitoneal or retroperitoneal approach were in...

    journal_title:Urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.urology.2013.05.011

    authors: Wu G,Zhang B,Yu C,Gao L,Gao Y,Huang Y,Yu L,Zhang G,Yang L,Yuan J

    更新日期:2013-09-01 00:00:00

  • Pararenal pseudocyst (urinoma) as complication of percutaneous nephrostomy.

    abstract::Percutaneous nephrostomy is a well-recognized procedure utilized by the radiologist both as a temporary drainage method for urinary tract obstruction and as the elective therapeutic modality in selected pathologies of the urinary tract. We report a complication not previously mentioned in the literature, urinoma forma...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(79)90478-3

    authors: Portela LA,Patel SK,Callahan DH

    更新日期:1979-05-01 00:00:00

  • An endoscopic study of the lacuna magna and reappraisal of its clinical significance in contemporary urological practice.

    abstract:OBJECTIVE:To endoscopically study the Lacuna Magna (LM) and attempt to explain some of the anatomical, clinical and embryological issues pertaining to it. The LM, stated to be present in 30 to 50 percent of males and linked to congenital distal urethral obstructions, post-void bloody-spotting and dysuria in young boys,...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2011.05.013

    authors: Shenoy SP,Marla PK,Venugopal P,Adappa KK,Tantry TP,Shankar M,Rai GD

    更新日期:2011-11-01 00:00:00

  • Unplanned Hospital Visits in the First 30 Days After Urethral Sling Procedures.

    abstract:OBJECTIVE:To evaluate unplanned hospital visits within 30 days of urethral sling placement in the form of emergency department visits, inpatient admissions, or repeat surgery. METHODS:We accessed nonpublic data from the Office of Statewide Health Planning and Development in the state of California for the years 2005-2...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2017.01.025

    authors: Dallas KB,Rogo-Gupta L,Elliott CS

    更新日期:2017-05-01 00:00:00

  • Invasively estimated International Continence Society obstruction classification versus noninvasively assessed bladder outlet obstruction probability in treatment recommendation for LUTS suggestive of BPH.

    abstract:OBJECTIVES:To investigate the contribution of urodynamically proven presence or absence (International Continence Society classification) of bladder outlet obstruction (BOO) to treatment recommendations for lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia, and to investigate the impact of ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2006.10.039

    authors: Boormans JL,van Venrooij GE,Boon TA

    更新日期:2007-03-01 00:00:00

  • Optical urethrotomy for anterior urethral stricture under a new local anesthesia: intracorpus spongiosum anesthesia.

    abstract:OBJECTIVES:To determine the feasibility of routinely performing internal urethrotomy for anterior urethral stricture under intracorpus spongiosum anesthesia in an outpatient setting. METHODS:In a consecutive series of 23 patients with anterior urethral stricture, a dosage of 3 mL of 1% lidocaine was slowly injected in...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(02)01732-6

    authors: Ye G,Rong-gui Z

    更新日期:2002-08-01 00:00:00

  • Longitudinal association between prostatitis and development of benign prostatic hyperplasia.

    abstract:OBJECTIVES:To determine whether physician-diagnosed prostatitis was associated with later development of benign prostatic hyperplasia (BPH)-associated events in a longitudinal, population-based sample of 2447 men residing in Olmsted County, Minnesota. METHODS:Medical records were reviewed for physician diagnosis of pr...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2007.11.155

    authors: St Sauver JL,Jacobson DJ,McGree ME,Girman CJ,Lieber MM,Jacobsen SJ

    更新日期:2008-03-01 00:00:00

  • Implications of Calcification in Peyronie's Disease, A Review of the Literature.

    abstract::A common characteristic of Peyronie's Disease (PD) is plaque calcification, which is associated with decreased response to treatments and higher rates of surgical intervention. Despite its prevalence in the PD population, the literature on plaque calcification is limited. While the diagnosis of PD is mostly clinical, ...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2021.01.007

    authors: Rainer QC,Rodriguez AA,Bajic P,Galor A,Ramasamy R,Masterson TA

    更新日期:2021-01-18 00:00:00

  • Elective open nephron-sparing surgery for renal masses: single-center experience with 129 consecutive patients.

    abstract:OBJECTIVES:To present our experience with elective, open, nephron-sparing surgery for renal masses in a contemporary, consecutive series. METHODS:In this retrospective study, the files of all patients who underwent elective nephron-sparing surgery between January 1996 and December 2002 at our institution were reviewed...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2004.02.007

    authors: Marszalek M,Ponholzer A,Brössner C,Wachter J,Maier U,Madersbacher S

    更新日期:2004-07-01 00:00:00

  • Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract is associated with disease recurrence in patients undergoing nephroureterectomy.

    abstract:OBJECTIVE:To investigate the impact of the expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract (UC-UUT) on the probability of intra- and extravesical disease recurrence in patients undergoing nephroureterectomy. METHODS:This study included 59 consecutive patients diagnose...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2011.07.1388

    authors: Muramaki M,Miyake H,Terakawa T,Kusuda Y,Fujisawa M

    更新日期:2011-12-01 00:00:00

  • Initial Management of Disorders of Sex Development in Newborns.

    abstract::Disorders of sex development are challenging to evaluate and diagnose in the newborn. As pediatric urologists, our goals are to (1) identify patients who should be evaluated; (2) rule out life-threatening syndromes; and (3) involve a multidisciplinary team for evaluation, diagnosis, and gender assignment. This review ...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2016.08.010

    authors: McNamara ER,Swartz JM,Diamond DA

    更新日期:2017-03-01 00:00:00

  • The impact of OAB on physical activity in the United States: results from OAB-POLL.

    abstract:OBJECTIVE:To provide data on physical activity among those with and without overactive bladder (OAB) in a large, ethnically diverse U.S. sample. METHODS:A cross-sectional survey was conducted via the Internet among 10,000 men and women aged 18-70 (2000 African Americans, 2000 Hispanics, and 6000 whites) using the lowe...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2013.05.035

    authors: Coyne KS,Sexton CC,Clemens JQ,Thompson CL,Chen CI,Bavendam T,Dmochowski R

    更新日期:2013-10-01 00:00:00